SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ0_A_SANA561_1
(DIHYDROPTEROATE
SYNTHASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 598
ARG A 806
LYS A 807
HIS A 844
 PMM  A1865 (-4.1A)
None
PMM  A1865 (-2.8A)
PMM  A1865 (-4.0A)
 0.78A 1aj0A-2bmbA:
33.9		 1aj0A-2bmbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 731
GLY A 732
LEU A 777
TYR A 780
 None
 0.91A 1fduD-2bmbA:
2.4		 1fduD-2bmbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 551
ASP A 636
ILE A 679
ASP A 755
SER A 805
 PMM  A1865 ( 3.8A)
PMM  A1865 (-3.3A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.2A)
None
 0.89A 1q8jA-2bmbA:
11.7		 1q8jA-2bmbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 636
ASN A 655
ILE A 679
ASP A 755
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.2A)
PMM  A1865 (-3.5A)
None
 0.62A 1q8jA-2bmbA:
11.7		 1q8jA-2bmbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 551
ASP A 636
ASN A 655
ILE A 679
SER A 805
 PMM  A1865 ( 3.8A)
PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
None
 0.91A 1q8jB-2bmbA:
18.9		 1q8jB-2bmbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 636
ASN A 655
ILE A 679
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 0.57A 1q8jB-2bmbA:
18.9		 1q8jB-2bmbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.74A 1rxcB-2bmbA:
undetectable		 1rxcB-2bmbA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.78A 1rxcE-2bmbA:
undetectable		 1rxcE-2bmbA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.78A 1rxcI-2bmbA:
undetectable		 1rxcI-2bmbA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.73A 1rxcK-2bmbA:
undetectable		 1rxcK-2bmbA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 597
ILE A 679
GLY A 757
ILE A 657
VAL A 800
 PMM  A1865 (-3.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 ( 4.8A)
PMM  A1865 (-4.8A)
None
 1.45A 1vq1A-2bmbA:
undetectable		 1vq1A-2bmbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 591
ASN A 655
ILE A 679
GLY A 803
SER A 805
 None
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 1.24A 2e7fA-2bmbA:
19.9		 2e7fA-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 636
ASN A 655
ILE A 679
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 0.59A 2e7fA-2bmbA:
19.9		 2e7fA-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 409
LEU A 407
LEU A 406
ILE A 435
LEU A 433
 None
 1.15A 2f7aA-2bmbA:
undetectable		 2f7aA-2bmbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 577
ILE A 546
VAL A 588
ALA A 548
 None
 0.90A 2j5mA-2bmbA:
undetectable		 2j5mA-2bmbA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 582
ILE A 589
ALA A 548
ALA A 581
LEU A 626
 None
 1.22A 2japB-2bmbA:
2.5		 2japB-2bmbA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 633
LEU A 510
ARG A 519
MET A 840
LEU A 753
 None
 1.45A 2oaxA-2bmbA:
undetectable		 2oaxA-2bmbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 633
LEU A 510
ARG A 519
MET A 840
LEU A 753
 None
 1.42A 2oaxD-2bmbA:
undetectable		 2oaxD-2bmbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 591
ASN A 655
ILE A 679
GLY A 803
SER A 805
 None
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 1.22A 2ogyA-2bmbA:
19.8		 2ogyA-2bmbA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 636
ASN A 655
ILE A 679
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 0.64A 2ogyA-2bmbA:
19.8		 2ogyA-2bmbA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 591
ASN A 655
ILE A 679
GLY A 803
SER A 805
 None
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 1.19A 2ogyB-2bmbA:
19.8		 2ogyB-2bmbA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 636
ASN A 655
ILE A 679
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 0.65A 2ogyB-2bmbA:
19.8		 2ogyB-2bmbA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 810
ARG A 822
PRO A 756
GLY A 759
 None
 1.13A 2pnjB-2bmbA:
2.4		 2pnjB-2bmbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 476
ASN A 712
ARG A 796
 None
 1.08A 2qeuB-2bmbA:
2.7		 2qeuB-2bmbA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 591
ASN A 655
ILE A 679
ASP A 755
GLY A 803
SER A 805
 None
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.2A)
PMM  A1865 (-3.5A)
None
 1.26A 2ycjA-2bmbA:
20.4		 2ycjA-2bmbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 636
ASN A 655
ILE A 679
ASP A 755
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.2A)
PMM  A1865 (-3.5A)
None
 0.73A 2ycjA-2bmbA:
20.4		 2ycjA-2bmbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 763
ILE A 770
ASN A 691
LEU A 727
PRO A 756
 None
 1.21A 3a50B-2bmbA:
undetectable		 3a50B-2bmbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 679
LEU A 801
ARG A 738
THR A 683
 PMM  A1865 ( 4.7A)
PMM  A1865 (-4.7A)
None
None
 1.04A 3ag4N-2bmbA:
undetectable
3ag4W-2bmbA:
undetectable		 3ag4N-2bmbA:
20.91
3ag4W-2bmbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 594
ARG A 639
ASP A 573
ILE A 574
LEU A 616
 None
 0.99A 3ihtA-2bmbA:
undetectable		 3ihtA-2bmbA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 470
CYH A 471
PHE A 341
TYR A 792
 None
 1.14A 3po7A-2bmbA:
undetectable		 3po7A-2bmbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 395
VAL A 368
LEU A 470
MET A 437
 None
 0.91A 3rgfA-2bmbA:
undetectable		 3rgfA-2bmbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 8 THR A 597
PRO A 599
GLY A 759
PHE A 760
LYS A 807
 PMM  A1865 (-3.9A)
None
None
PMM  A1865 (-4.7A)
PMM  A1865 (-2.8A)
 0.43A 3tzfB-2bmbA:
35.8		 3tzfB-2bmbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 679
LEU A 801
ARG A 738
THR A 683
 PMM  A1865 ( 4.7A)
PMM  A1865 (-4.7A)
None
None
 1.19A 3wg7A-2bmbA:
undetectable
3wg7J-2bmbA:
undetectable		 3wg7A-2bmbA:
20.91
3wg7J-2bmbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 461
LEU A 470
CYH A 471
PHE A 341
TYR A 792
 None
 1.25A 4a79B-2bmbA:
undetectable		 4a79B-2bmbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 708
ILE A 705
HIS A 682
VAL A 800
 None
 0.89A 4a97A-2bmbA:
undetectable		 4a97A-2bmbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 591
ASP A 636
ASN A 655
ASP A 755
GLY A 803
SER A 805
 None
PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
PMM  A1865 (-3.5A)
None
 0.74A 4djeB-2bmbA:
20.1		 4djeB-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 591
ASP A 636
ASN A 655
ILE A 679
GLY A 803
SER A 805
 None
PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 0.69A 4djfB-2bmbA:
20.2		 4djfB-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.78A 4e1vA-2bmbA:
undetectable		 4e1vA-2bmbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.79A 4e1vC-2bmbA:
undetectable		 4e1vC-2bmbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.77A 4e1vD-2bmbA:
undetectable		 4e1vD-2bmbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.78A 4e1vE-2bmbA:
undetectable		 4e1vE-2bmbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.87A 4e1vG-2bmbA:
undetectable		 4e1vG-2bmbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 637
GLY A 593
ILE A 635
VAL A 592
 None
 0.81A 4e1vH-2bmbA:
undetectable		 4e1vH-2bmbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 736
GLY A 732
LEU A 701
VAL A 793
VAL A 791
 None
 0.87A 4htfB-2bmbA:
undetectable		 4htfB-2bmbA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 495
THR A 464
ARG A 796
PHE A 377
 None
 1.38A 4kf9A-2bmbA:
undetectable		 4kf9A-2bmbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		5 / 8 TRP A 750
VAL A 395
LEU A 370
LEU A 362
ILE A 355
 None
 1.47A 4lzrA-2bmbA:
undetectable		 4lzrA-2bmbA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 829
ALA A 825
ILE A 813
THR A 814
 None
 0.96A 5e4dB-2bmbA:
undetectable		 5e4dB-2bmbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 630
LEU A 510
ILE A 589
 None
 0.70A 5kc0A-2bmbA:
undetectable		 5kc0A-2bmbA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 756
ILE A 771
ILE A 774
ILE A 728
 None
 0.89A 5murB-2bmbA:
undetectable		 5murB-2bmbA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 551
ASP A 636
ASN A 655
ASP A 755
 PMM  A1865 ( 3.8A)
PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
 0.93A 5vooC-2bmbA:
18.1		 5vooC-2bmbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 636
ASN A 655
ASP A 755
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
 0.32A 5vopA-2bmbA:
17.8		 5vopA-2bmbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 636
ASN A 655
ASP A 755
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
 0.28A 5vopB-2bmbA:
7.6		 5vopB-2bmbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 844
ASP A 636
GLY A 593
ASN A 551
 PMM  A1865 (-4.0A)
PMM  A1865 (-3.3A)
None
PMM  A1865 ( 3.8A)
 1.19A 5x7pB-2bmbA:
0.0		 5x7pB-2bmbA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 747
SER A 640
ALA A 643
LYS A 644
 None
 0.60A 6hu9H-2bmbA:
undetectable
6hu9e-2bmbA:
0.9		 6hu9H-2bmbA:
11.64
6hu9e-2bmbA:
13.91