SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8O_A_OINA1317_1 (CHOLINE-BINDING PROTEIN F)	2bml	AUTOLYSIN (Streptococcus pneumoniae)	4 / 4	TRP A 220 TRP A 228 TYR A 249 MET A 257	TRS A1319 (-3.3A) TRS A1319 ( 4.1A) TRS A1319 ( 4.8A) TRS A1319 ( 4.1A)	0.34A	2x8oA-2bmlA: 8.3	2x8oA-2bmlA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8O_A_OINA1317_1 (CHOLINE-BINDING PROTEIN F)	2bml	AUTOLYSIN (Streptococcus pneumoniae)	4 / 4	TRP A 241 TRP A 248 TYR A 269 MET A 278	None	0.45A	2x8oA-2bmlA: 8.3	2x8oA-2bmlA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8P_A_OINA1313_1 (CHOLINE-BINDING PROTEIN F)	2bml	AUTOLYSIN (Streptococcus pneumoniae)	4 / 4	TRP A 220 LYS A 222 TRP A 228 TYR A 249	TRS A1319 (-3.3A) None TRS A1319 ( 4.1A) TRS A1319 ( 4.8A)	0.37A	2x8pA-2bmlA: 9.0	2x8pA-2bmlA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8P_A_OINA1313_1 (CHOLINE-BINDING PROTEIN F)	2bml	AUTOLYSIN (Streptococcus pneumoniae)	4 / 4	TRP A 241 LYS A 243 TRP A 248 TYR A 269	None	0.55A	2x8pA-2bmlA: 9.0	2x8pA-2bmlA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8P_A_OINA1313_1 (CHOLINE-BINDING PROTEIN F)	2bml	AUTOLYSIN (Streptococcus pneumoniae)	4 / 4	TRP A 261 LYS A 263 TRP A 268 TYR A 293	TRS A1320 (-3.2A) None TRS A1320 (-3.6A) TRS A1320 (-3.7A)	0.83A	2x8pA-2bmlA: 9.0	2x8pA-2bmlA: 21.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2X8O_A_OINA1317_1","CHOLINE-BINDING PROTEIN F","2bml","AUTOLYSIN","Streptococcus pneumoniae",4,"TRP A 220;TRP A 228;TYR A 249;MET A 257","TRS A1319 (-3.3A);TRS A1319 ( 4.1A);TRS A1319 ( 4.8A);TRS A1319 ( 4.1A)","0.34A","2x8oA-2bmlA:8.3","2x8oA-2bmlA:21.32"],["2X8O_A_OINA1317_1","CHOLINE-BINDING PROTEIN F","2bml","AUTOLYSIN","Streptococcus pneumoniae",4,"TRP A 241;TRP A 248;TYR A 269;MET A 278","None","0.45A","2x8oA-2bmlA:8.3","2x8oA-2bmlA:21.32"],["2X8P_A_OINA1313_1","CHOLINE-BINDING PROTEIN F","2bml","AUTOLYSIN","Streptococcus pneumoniae",4,"TRP A 220;LYS A 222;TRP A 228;TYR A 249","TRS A1319 (-3.3A);None;TRS A1319 ( 4.1A);TRS A1319 ( 4.8A)","0.37A","2x8pA-2bmlA:9.0","2x8pA-2bmlA:21.32"],["2X8P_A_OINA1313_1","CHOLINE-BINDING PROTEIN F","2bml","AUTOLYSIN","Streptococcus pneumoniae",4,"TRP A 241;LYS A 243;TRP A 248;TYR A 269","None","0.55A","2x8pA-2bmlA:9.0","2x8pA-2bmlA:21.32"],["2X8P_A_OINA1313_1","CHOLINE-BINDING PROTEIN F","2bml","AUTOLYSIN","Streptococcus pneumoniae",4,"TRP A 261;LYS A 263;TRP A 268;TYR A 293","TRS A1320 (-3.2A);None;TRS A1320 (-3.6A);TRS A1320 (-3.7A)","0.83A","2x8pA-2bmlA:9.0","2x8pA-2bmlA:21.32"]]