SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSE_A_EAAA224_1 (GLUTATHIONE TRANSFERASE)	2bmx	ALKYL HYDROPEROXIDASE C (Mycobacterium tuberculosis)	5 / 12	LEU A 111 LEU A 83 VAL A 50 ALA A 122 PHE A 10	None	1.05A	1gseA-2bmxA: undetectable	1gseA-2bmxA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSE_B_EAAB224_1 (GLUTATHIONE TRANSFERASE)	2bmx	ALKYL HYDROPEROXIDASE C (Mycobacterium tuberculosis)	5 / 12	LEU A 111 LEU A 83 VAL A 50 ALA A 122 PHE A 10	None	1.05A	1gseB-2bmxA: undetectable	1gseB-2bmxA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8L_A_SAMA400_0 (HYPOTHETICAL PROTEIN LMO1582)	2bmx	ALKYL HYDROPEROXIDASE C (Mycobacterium tuberculosis)	5 / 12	ALA A 121 GLY A 123 ASN A 126 LEU A 125 LEU A 3	None	1.11A	2f8lA-2bmxA: undetectable	2f8lA-2bmxA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLC_A_CHDA332_0 (CHOLOYLGLYCINE HYDROLASE)	2bmx	ALKYL HYDROPEROXIDASE C (Mycobacterium tuberculosis)	6 / 12	ILE A 144 PHE A 136 PHE A 51 ALA A 122 ASN A 142 ILE A 82	None	1.37A	2rlcA-2bmxA: undetectable	2rlcA-2bmxA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE)	2bmx	ALKYL HYDROPEROXIDASE C (Mycobacterium tuberculosis)	4 / 8	ARG A 78 LEU A 83 GLY A 84 PHE A 51	None	0.88A	2tsrB-2bmxA: undetectable	2tsrB-2bmxA: 20.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GSE_A_EAAA224_1","GLUTATHIONE TRANSFERASE","2bmx","ALKYL HYDROPEROXIDASE C","Mycobacterium tuberculosis",5,"LEU A 111;LEU A  83;VAL A  50;ALA A 122;PHE A  10","None","1.05A","1gseA-2bmxA:undetectable","1gseA-2bmxA:21.03"],["1GSE_B_EAAB224_1","GLUTATHIONE TRANSFERASE","2bmx","ALKYL HYDROPEROXIDASE C","Mycobacterium tuberculosis",5,"LEU A 111;LEU A  83;VAL A  50;ALA A 122;PHE A  10","None","1.05A","1gseB-2bmxA:undetectable","1gseB-2bmxA:21.03"],["2F8L_A_SAMA400_0","HYPOTHETICAL PROTEIN LMO1582","2bmx","ALKYL HYDROPEROXIDASE C","Mycobacterium tuberculosis",5,"ALA A 121;GLY A 123;ASN A 126;LEU A 125;LEU A   3","None","1.11A","2f8lA-2bmxA:undetectable","2f8lA-2bmxA:17.00"],["2RLC_A_CHDA332_0","CHOLOYLGLYCINE HYDROLASE","2bmx","ALKYL HYDROPEROXIDASE C","Mycobacterium tuberculosis",6,"ILE A 144;PHE A 136;PHE A  51;ALA A 122;ASN A 142;ILE A  82","None","1.37A","2rlcA-2bmxA:undetectable","2rlcA-2bmxA:20.18"],["2TSR_B_D16B409_1","THYMIDYLATE SYNTHASE","2bmx","ALKYL HYDROPEROXIDASE C","Mycobacterium tuberculosis",4,"ARG A  78;LEU A  83;GLY A  84;PHE A  51","None","0.88A","2tsrB-2bmxA:undetectable","2tsrB-2bmxA:20.95"]]