SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 MET A 150
LEU A 153
SER A 154
 None
 0.62A 1ee2A-2bnxA:
undetectable		 1ee2A-2bnxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU A 234
MET A 225
THR A 224
LEU A 179
 None
 1.06A 2dyrA-2bnxA:
0.5
2dyrJ-2bnxA:
undetectable		 2dyrA-2bnxA:
20.88
2dyrJ-2bnxA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU A 234
MET A 225
THR A 224
LEU A 179
 None
 1.07A 2dysA-2bnxA:
0.0
2dysJ-2bnxA:
undetectable		 2dysA-2bnxA:
20.88
2dysJ-2bnxA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU A 234
MET A 225
THR A 224
LEU A 179
 None
 1.08A 2eijA-2bnxA:
0.8
2eijJ-2bnxA:
undetectable		 2eijA-2bnxA:
20.88
2eijJ-2bnxA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 THR A 297
ASP A 240
SER A 202
 None
 0.76A 2nxeA-2bnxA:
undetectable		 2nxeA-2bnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 THR A 297
ASP A 240
SER A 202
 None
 0.75A 2nxeB-2bnxA:
undetectable		 2nxeB-2bnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 11 LEU A 147
ARG A 148
ILE A 185
LEU A 189
ASP A 201
 None
 1.27A 2qeiA-2bnxA:
2.7		 2qeiA-2bnxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU A 234
MET A 225
THR A 224
LEU A 179
 None
 1.06A 3abmA-2bnxA:
0.0
3abmJ-2bnxA:
undetectable		 3abmA-2bnxA:
20.88
3abmJ-2bnxA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU A 234
MET A 225
THR A 224
LEU A 179
 None
 1.08A 3asnA-2bnxA:
undetectable
3asnJ-2bnxA:
undetectable		 3asnA-2bnxA:
20.88
3asnJ-2bnxA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU A 234
MET A 225
THR A 224
LEU A 179
 None
 1.06A 3asoA-2bnxA:
undetectable
3asoJ-2bnxA:
undetectable		 3asoA-2bnxA:
20.88
3asoJ-2bnxA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA A 251
ILE A 248
THR A 297
SER A 298
LEU A 341
 None
 0.94A 3cl9A-2bnxA:
undetectable		 3cl9A-2bnxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 11 ALA A 238
ILE A 208
GLY A 231
ILE A 232
ILE A 209
 None
 1.07A 3ebzA-2bnxA:
undetectable		 3ebzA-2bnxA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 ARG A 203
GLU A 207
ASN A 204
 None
 0.79A 4imaD-2bnxA:
undetectable		 4imaD-2bnxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 ARG A 203
GLU A 207
ASN A 204
 None
 0.82A 4ip7D-2bnxA:
undetectable		 4ip7D-2bnxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA A 238
LEU A 234
LEU A 212
ILE A 185
LEU A 156
 None
 1.17A 4q0dA-2bnxA:
undetectable		 4q0dA-2bnxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA A 238
LEU A 234
LEU A 212
ILE A 185
LEU A 156
 None
 1.17A 4q0dB-2bnxA:
undetectable		 4q0dB-2bnxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA A 238
LEU A 234
LEU A 212
ILE A 185
LEU A 156
 None
 1.17A 4q0dE-2bnxA:
undetectable		 4q0dE-2bnxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 7 MET A 280
GLU A 276
GLU A 230
GLU A 229
 None
 1.48A 4r87J-2bnxA:
0.0
4r87L-2bnxA:
0.0		 4r87J-2bnxA:
19.38
4r87L-2bnxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 10 ALA A 278
VAL A 236
LEU A 308
LEU A 289
PHE A 286
 None
 1.17A 4zmeB-2bnxA:
undetectable		 4zmeB-2bnxA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2bnx DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 7 ILE A 232
LEU A 235
ARG A 285
LEU A 308
 None
 0.96A 5xdxA-2bnxA:
undetectable
5xdxJ-2bnxA:
undetectable		 5xdxA-2bnxA:
20.88
5xdxJ-2bnxA:
8.91