SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2boa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 TRP A1294
ILE A1096
LEU A1295
GLU A1302
 None
 1.22A 1xvaA-2boaA:
undetectable
1xvaB-2boaA:
undetectable		 1xvaA-2boaA:
20.97
1xvaB-2boaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 7 SER A1199
SER A1197
PHE A1279
GLU A1270
 None
 1.18A 2c8aA-2boaA:
undetectable		 2c8aA-2boaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 7 GLY A1278
SER A1199
SER A1197
PHE A1279
GLU A1270
 None
 1.27A 2c8aB-2boaA:
undetectable		 2c8aB-2boaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 7 GLY A1278
SER A1199
SER A1197
PHE A1279
GLU A1270
 None
 1.30A 2c8aD-2boaA:
undetectable		 2c8aD-2boaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 SER A1197
LEU A1280
GLY A1278
ARG A1124
 None
 0.93A 2j2pA-2boaA:
undetectable
2j2pB-2boaA:
undetectable		 2j2pA-2boaA:
19.55
2j2pB-2boaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ARG A1124
SER A1197
LEU A1280
GLY A1278
 None
 1.03A 2j2pA-2boaA:
undetectable
2j2pC-2boaA:
undetectable		 2j2pA-2boaA:
19.55
2j2pC-2boaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ARG A1124
SER A1197
LEU A1280
GLY A1278
 None
 1.01A 2j2pD-2boaA:
undetectable
2j2pF-2boaA:
undetectable		 2j2pD-2boaA:
19.55
2j2pF-2boaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 8 GLU A1072
LEU A1108
ILE A1068
VAL A1179
ILE A1183
 ZN  A1402 (-1.6A)
None
None
None
None
 1.46A 2uxpA-2boaA:
undetectable		 2uxpA-2boaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 10 LEU A  61
ALA A  63
LEU A  35
VAL A  56
ILE A  15
 None
 1.15A 2w9gA-2boaA:
undetectable		 2w9gA-2boaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 8 LEU A1064
ILE A1193
LEU A1297
THR A1082
LEU A1107
 None
 1.42A 2xfhA-2boaA:
undetectable		 2xfhA-2boaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 8 VAL A1062
LEU A1202
GLY A1296
ALA A1226
 None
 0.91A 2xfsA-2boaA:
undetectable		 2xfsA-2boaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 8 VAL A1062
LEU A1202
GLY A1296
ALA A1226
 None
 0.93A 2xh9A-2boaA:
undetectable		 2xh9A-2boaA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 SER A1070
ASN A1112
THR A1119
VAL A1117
SER A1041
 None
 1.36A 2xpvA-2boaA:
undetectable		 2xpvA-2boaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 THR A1289
THR A1293
LEU A1195
THR A1078
 None
 0.63A 3deuB-2boaA:
1.3		 3deuB-2boaA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 11 LEU A  61
ALA A  63
LEU A  35
VAL A  56
ILE A  15
 None
 1.09A 3frbX-2boaA:
undetectable		 3frbX-2boaA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 9 ALA A  63
LEU A  29
LEU A  35
VAL A  56
ILE A  15
 None
 1.29A 3freX-2boaA:
undetectable		 3freX-2boaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 ILE A1263
ALA A1061
LEU A1064
ILE A1300
TYR A1309
 None
 1.01A 3ia4B-2boaA:
undetectable		 3ia4B-2boaA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 ILE A1018
VAL A1117
MET A1047
PRO A1046
SER A1041
 None
 1.04A 3iw1A-2boaA:
undetectable		 3iw1A-2boaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 PHE A1052
MET A1022
THR A1054
ALA A1066
ILE A1193
 None
 1.10A 3nxuB-2boaA:
undetectable		 3nxuB-2boaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 THR A1129
GLY A1115
PRO A1113
ASN A1112
 None
 0.87A 3u8qA-2boaA:
undetectable		 3u8qA-2boaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 8 TYR A1012
TRP A1073
LEU A1125
TRP A  38
 None
 1.29A 3uzzB-2boaA:
undetectable		 3uzzB-2boaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 GLY A1278
ASP A  53
ASN A  36
GLU A1163
 None
 0.97A 3vywC-2boaA:
undetectable		 3vywC-2boaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A1237
GLY A1235
TYR A1238
GLU A1292
 None
 1.28A 3w9tA-2boaA:
undetectable		 3w9tA-2boaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A1237
GLY A1235
TYR A1238
GLU A1292
 None
 1.27A 3w9tC-2boaA:
undetectable		 3w9tC-2boaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A1237
GLY A1235
TYR A1238
GLU A1292
 None
 1.28A 3w9tD-2boaA:
undetectable		 3w9tD-2boaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A1237
GLY A1235
TYR A1238
GLU A1292
 None
 1.27A 3w9tG-2boaA:
undetectable		 3w9tG-2boaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 THR A1129
GLY A1115
PRO A1113
ASN A1112
 None
 0.86A 4fjpA-2boaA:
undetectable		 4fjpA-2boaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 ILE A1018
ASN A1008
TYR A1009
ILE A1080
 None
 0.90A 4jtpA-2boaA:
undetectable		 4jtpA-2boaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 ILE A1105
VAL A1180
THR A1078
LEU A1195
HIS A1196
 None
None
None
None
ZN  A1402 (-3.1A)
 1.22A 5esgA-2boaA:
undetectable		 5esgA-2boaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 LEU A1308
ALA A1266
PHE A1192
GLY A1191
PRO A1060
 None
 1.27A 5jglA-2boaA:
undetectable		 5jglA-2boaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 PHE A  37
SER A  40
ASN A1159
ASP A1158
 None
 1.32A 5kpcA-2boaA:
undetectable		 5kpcA-2boaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A  89
TYR A1012
TYR A1116
ARG A1124
 None
 1.36A 5mthA-2boaA:
0.0
5mthB-2boaA:
0.0		 5mthA-2boaA:
19.95
5mthB-2boaA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A  89
TYR A1012
TYR A1116
ARG A1124
 None
 1.34A 5mthH-2boaA:
0.0
5mthL-2boaA:
0.0		 5mthH-2boaA:
19.95
5mthL-2boaA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2boa CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ILE A1074
ILE A1086
LEU A1107
PHE A1029
 None
 1.04A 5vkqC-2boaA:
undetectable
5vkqD-2boaA:
undetectable		 5vkqC-2boaA:
12.23
5vkqD-2boaA:
12.23