SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bod'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 6 LYS X 202
ALA X 201
SER X 160
THR X 186
 None
 1.07A 1ictB-2bodX:
undetectable		 1ictB-2bodX:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		3 / 3 TRP X  97
GLN X  49
TRP X  41
 None
None
BGC  X1290 ( 3.5A)
 1.36A 2vqyA-2bodX:
0.0		 2vqyA-2bodX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.17A 2x2iA-2bodX:
2.3		 2x2iA-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 10 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.24A 2x2iB-2bodX:
2.7		 2x2iB-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.10A 2x2iC-2bodX:
4.5		 2x2iC-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLY X 104
GLY X  52
ASP X  55
GLU X 100
ALA X 103
 None
 1.28A 3t7sA-2bodX:
undetectable		 3t7sA-2bodX:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLU X 197
ASP X 218
ASP X 117
GLY X 158
SER X 160
 None
None
SGC  X1288 (-3.8A)
None
None
 1.36A 4djeB-2bodX:
7.4		 4djeB-2bodX:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLU X 197
ASP X 218
ILE X 113
GLY X 158
SER X 160
 None
 1.45A 4djfB-2bodX:
7.5		 4djfB-2bodX:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 4 LYS X 202
ALA X 201
SER X 160
THR X 186
 None
 1.33A 4i89B-2bodX:
0.0		 4i89B-2bodX:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 5 ILE X 208
LEU X 213
ASP X 176
VAL X 114
 None
 1.03A 4nkxB-2bodX:
undetectable		 4nkxB-2bodX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 4 ALA X  61
VAL X   7
GLY X  39
THR X  40
 None
 1.13A 4ubeA-2bodX:
2.3		 4ubeA-2bodX:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 6 ALA X 151
SER X 149
GLN X  62
PRO X  68
 None
 1.20A 5c6pA-2bodX:
undetectable		 5c6pA-2bodX:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 6 ALA X 283
GLN X  38
SER X  35
PRO X 242
 None
 1.16A 5c6pA-2bodX:
undetectable		 5c6pA-2bodX:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 ASP X  99
TRP X  97
ALA X  75
ALA X  88
TYR X 139
 None
 1.40A 5cxvA-2bodX:
undetectable		 5cxvA-2bodX:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLY X 141
SER X 148
ILE X  98
VAL X 114
VAL X  72
 None
 1.02A 5dpdA-2bodX:
undetectable		 5dpdA-2bodX:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLY X 141
SER X 148
ILE X  98
VAL X 114
VAL X  72
 None
 1.01A 5dpdB-2bodX:
undetectable		 5dpdB-2bodX:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 6 LYS X 259
ARG X 221
GLY X 266
ASP X 233
 BGC  X1289 ( 2.7A)
BGC  X1289 ( 4.7A)
None
None
 1.20A 5hp1A-2bodX:
undetectable		 5hp1A-2bodX:
18.43