SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 12 THR A  45
GLY A 170
THR A 105
ALA A 104
LEU A 138
 None
 1.12A 1jg4A-2bp1A:
undetectable		 1jg4A-2bp1A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 6 ALA A 296
ILE A 274
VAL A 277
GLU A 278
 None
 0.93A 2cizA-2bp1A:
0.0		 2cizA-2bp1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		3 / 3 ARG A 206
GLU A 278
SER A 304
 None
 0.92A 2xkkA-2bp1A:
undetectable
2xkkC-2bp1A:
undetectable		 2xkkA-2bp1A:
18.13
2xkkC-2bp1A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 12 GLY A  96
LEU A  87
GLY A  93
LEU A  72
LEU A  43
 None
 1.00A 2zbpA-2bp1A:
undetectable		 2zbpA-2bp1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 8 LEU A  92
THR A 105
VAL A 101
GLY A  95
 None
 0.82A 3dcjB-2bp1A:
undetectable		 3dcjB-2bp1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 6 VAL A 196
TYR A 140
TYR A 224
GLU A  71
 None
 0.83A 3q5sA-2bp1A:
undetectable		 3q5sA-2bp1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 12 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.21A 3qxyA-2bp1A:
undetectable		 3qxyA-2bp1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 11 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.17A 3qxyB-2bp1A:
undetectable
3qxyQ-2bp1A:
undetectable		 3qxyB-2bp1A:
23.64
3qxyQ-2bp1A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 11 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.18A 3rc0A-2bp1A:
undetectable		 3rc0A-2bp1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 12 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.18A 3rc0B-2bp1A:
undetectable		 3rc0B-2bp1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 6 TYR A 226
GLY A 199
HIS A 142
SER A 172
 NDP  A1361 (-3.3A)
None
FLC  A1362 ( 3.9A)
NDP  A1361 (-2.7A)
 1.09A 3tj7A-2bp1A:
undetectable
3tj7B-2bp1A:
undetectable		 3tj7A-2bp1A:
18.33
3tj7B-2bp1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 6 TYR A 226
GLY A 199
HIS A 142
SER A 172
 NDP  A1361 (-3.3A)
None
FLC  A1362 ( 3.9A)
NDP  A1361 (-2.7A)
 1.09A 3tj7C-2bp1A:
undetectable
3tj7D-2bp1A:
undetectable		 3tj7C-2bp1A:
18.33
3tj7D-2bp1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 6 HIS A 142
SER A 172
TYR A 226
GLY A 199
 FLC  A1362 ( 3.9A)
NDP  A1361 (-2.7A)
NDP  A1361 (-3.3A)
None
 1.12A 3tj7C-2bp1A:
undetectable
3tj7D-2bp1A:
undetectable		 3tj7C-2bp1A:
18.33
3tj7D-2bp1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		3 / 3 PHE A  76
LYS A 113
SER A 114
 None
 1.25A 3tyeB-2bp1A:
6.0		 3tyeB-2bp1A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 6 THR A  74
GLY A  44
ILE A 315
LEU A  72
 None
NDP  A1361 (-3.1A)
NDP  A1361 (-3.6A)
None
 1.05A 4acbC-2bp1A:
2.2		 4acbC-2bp1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 5 THR A  70
THR A  45
LEU A 131
LEU A  94
 None
 1.03A 4lvcB-2bp1A:
undetectable		 4lvcB-2bp1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 4 ALA A  56
ALA A  59
ALA A  60
ALA A  63
 None
 0.06A 4oadA-2bp1A:
undetectable		 4oadA-2bp1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 4 ALA A  56
ALA A  59
ALA A  60
ALA A  63
 None
 0.07A 4oaeA-2bp1A:
0.1		 4oaeA-2bp1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		3 / 3 PRO A 194
LEU A 169
GLN A 158
 None
 0.71A 4pevB-2bp1A:
undetectable		 4pevB-2bp1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		4 / 7 PHE A 223
LEU A 216
VAL A 208
PHE A 359
 None
 0.93A 4wnvD-2bp1A:
undetectable		 4wnvD-2bp1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens) 		5 / 9 LEU A 115
THR A 153
LEU A 154
ILE A 182
LEU A 185
 None
 1.28A 5g48B-2bp1A:
undetectable		 5g48B-2bp1A:
21.84