SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 265
VAL A 269
TRP A 262
 None
 0.85A 1tkqB-2bpqA:
undetectable		 1tkqB-2bpqA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  66
TYR A 186
ILE A 196
ILE A  62
 None
 0.97A 2dcfA-2bpqA:
undetectable		 2dcfA-2bpqA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1603_0
(FERROCHELATASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 5 MET A 230
LEU A 144
PRO A  74
MET A  69
 None
None
BEN  A1369 ( 4.2A)
None
 1.35A 2hrcB-2bpqA:
1.6		 2hrcB-2bpqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 276
ILE A 261
ASN A 319
LEU A 218
 None
 1.15A 2wekB-2bpqA:
2.2		 2wekB-2bpqA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  66
TYR A 186
ILE A 196
ILE A  62
 None
 0.96A 2zm7A-2bpqA:
undetectable		 2zm7A-2bpqA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  66
TYR A 186
ILE A 196
ILE A  62
 None
 0.95A 2zm8A-2bpqA:
undetectable		 2zm8A-2bpqA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  66
TYR A 186
ILE A 196
ILE A  62
 None
 0.96A 2zmaA-2bpqA:
undetectable		 2zmaA-2bpqA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 242
LEU A 218
GLY A 217
VAL A 131
VAL A 126
 None
 1.30A 3lxiB-2bpqA:
undetectable		 3lxiB-2bpqA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 322
ALA A 321
ALA A 129
ARG A 346
 None
 0.84A 3ur0B-2bpqA:
undetectable		 3ur0B-2bpqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 242
LEU A 218
GLY A 217
VAL A 131
VAL A 126
 None
 1.35A 4c9pB-2bpqA:
undetectable		 4c9pB-2bpqA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 113
GLY A 109
THR A 115
LEU A 250
SER A 259
 None
 1.47A 4or0A-2bpqA:
0.9		 4or0A-2bpqA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 113
GLY A 110
THR A 115
LEU A 250
SER A 259
 None
 1.48A 4or0A-2bpqA:
0.9		 4or0A-2bpqA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 137
GLY A 146
LEU A 144
ILE A 158
ALA A 179
 None
 1.08A 4qtuB-2bpqA:
2.6		 4qtuB-2bpqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 304
VAL A 301
ILE A 324
ALA A 321
VAL A 126
 None
 1.15A 5n0sB-2bpqA:
undetectable		 5n0sB-2bpqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 122
GLY A 217
ILE A 261
PHE A 274
 None
None
None
GOL  A1370 (-4.2A)
 0.88A 6f8cA-2bpqA:
undetectable		 6f8cA-2bpqA:
12.16