SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 ALA X 239
VAL X  10
TRP X  13
 None
 0.90A 1c4dC-2bq8X:
undetectable
1c4dD-2bq8X:
undetectable		 1c4dC-2bq8X:
6.11
1c4dD-2bq8X:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 TRP X  13
ALA X 239
VAL X  10
 None
 0.77A 1c4dC-2bq8X:
undetectable
1c4dD-2bq8X:
undetectable		 1c4dC-2bq8X:
6.11
1c4dD-2bq8X:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.16A 1d4fA-2bq8X:
undetectable		 1d4fA-2bq8X:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 11 HIS X  92
TYR X 215
LEU X 199
LEU X 139
THR X 138
 None
 1.27A 1dmyA-2bq8X:
undetectable		 1dmyA-2bq8X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 5 GLN X  66
TRP X 109
GLU X  70
TRP X  13
 None
None
SO4  X1308 ( 4.0A)
None
 1.30A 1ulvA-2bq8X:
0.0		 1ulvA-2bq8X:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 7 LEU X 236
PRO X 186
GLY X  88
ASP X  50
 None
None
None
FE2  X1306 ( 2.8A)
 0.94A 2ddwB-2bq8X:
undetectable		 2ddwB-2bq8X:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 7 ASN X 241
TRP X  13
GLY X  15
THR X  68
 None
 1.16A 2o5yH-2bq8X:
undetectable
2o5yL-2bq8X:
undetectable		 2o5yH-2bq8X:
22.03
2o5yL-2bq8X:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 6 ASP X 144
HIS X 193
HIS X 221
ASP X  12
 None
None
FE2  X1305 (-3.4A)
FE2  X1305 (-3.1A)
 1.13A 3c0zC-2bq8X:
undetectable		 3c0zC-2bq8X:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 TYR X 185
GLY X  88
ASP X  50
 None
None
FE2  X1306 ( 2.8A)
 0.72A 3ou6C-2bq8X:
undetectable		 3ou6C-2bq8X:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 11 VAL X  10
TRP X  13
HIS X 184
ASN X  51
GLU X  26
 None
None
FE2  X1306 (-3.3A)
None
None
 1.46A 4c1fA-2bq8X:
undetectable
4c1fB-2bq8X:
undetectable		 4c1fA-2bq8X:
22.93
4c1fB-2bq8X:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 LEU X 139
GLY X 218
THR X 136
LEU X 134
GLY X 194
 None
 1.03A 4dc3A-2bq8X:
undetectable		 4dc3A-2bq8X:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 ALA X 272
GLY X  11
GLY X 238
ASP X  12
ALA X   9
 None
None
None
FE2  X1305 (-3.1A)
None
 0.95A 4lg1A-2bq8X:
undetectable		 4lg1A-2bq8X:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 ALA X 272
GLY X  11
GLY X 238
ASP X  12
ALA X   9
 None
None
None
FE2  X1305 (-3.1A)
None
 0.95A 4lg1C-2bq8X:
undetectable		 4lg1C-2bq8X:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 7 HIS X  90
GLY X  88
ASN X  89
HIS X 219
 None
None
None
FE2  X1306 (-3.2A)
 0.98A 5a5zC-2bq8X:
undetectable		 5a5zC-2bq8X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.16A 5axdA-2bq8X:
undetectable		 5axdA-2bq8X:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 SER X 189
HIS X 184
ASP X  50
HIS X 221
ASP X 145
 None
FE2  X1306 (-3.3A)
FE2  X1306 ( 2.8A)
FE2  X1305 (-3.4A)
FE2  X1306 ( 2.5A)
 1.38A 5ef8B-2bq8X:
undetectable		 5ef8B-2bq8X:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 5 LEU X 236
HIS X 219
THR X 196
CYH X 217
 None
FE2  X1306 (-3.2A)
None
None
 1.43A 5eu8A-2bq8X:
0.0		 5eu8A-2bq8X:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 ILE X 131
VAL X 274
ALA X 272
VAL X 235
GLY X 240
 None
 1.18A 5igiA-2bq8X:
undetectable		 5igiA-2bq8X:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 8 LEU X 164
LEU X 139
LEU X 207
TYR X 215
LEU X 206
 None
 1.42A 5jqbA-2bq8X:
undetectable
5jqbB-2bq8X:
undetectable		 5jqbA-2bq8X:
23.10
5jqbB-2bq8X:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 6 GLY X 270
SER X 237
GLY X  11
ASN X  29
 None
 0.67A 5k4pA-2bq8X:
undetectable		 5k4pA-2bq8X:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 ASP X  50
LEU X 159
HIS X  92
GLY X 183
LEU X 134
 FE2  X1306 ( 2.8A)
None
None
None
None
 1.33A 5m50E-2bq8X:
undetectable		 5m50E-2bq8X:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.18A 5m66C-2bq8X:
undetectable		 5m66C-2bq8X:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 HIS X 219
ASP X 220
HIS X 193
 FE2  X1306 (-3.2A)
None
None
 0.90A 5n1tW-2bq8X:
undetectable		 5n1tW-2bq8X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 VAL X 212
MET X 281
ALA X   4
PHE X   7
LEU X 216
 None
 1.25A 5tudD-2bq8X:
undetectable		 5tudD-2bq8X:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.16A 5v96A-2bq8X:
undetectable		 5v96A-2bq8X:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.17A 5v96B-2bq8X:
undetectable		 5v96B-2bq8X:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.18A 5v96C-2bq8X:
undetectable		 5v96C-2bq8X:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 12 THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
 None
None
FE2  X1305 (-3.1A)
None
None
 1.14A 5v96D-2bq8X:
undetectable		 5v96D-2bq8X:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 ASP X  62
ARG X  64
ASP X  91
 None
 0.88A 5zvgA-2bq8X:
undetectable		 5zvgA-2bq8X:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 ASP X  62
ARG X  64
ASP X  91
 None
 0.85A 5zvgB-2bq8X:
undetectable		 5zvgB-2bq8X:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		3 / 3 TYR X 215
ALA X   9
LEU X  46
 None
 0.60A 6ag0C-2bq8X:
undetectable		 6ag0C-2bq8X:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		4 / 5 PRO X 114
VAL X  96
GLY X  11
VAL X  85
 None
 1.11A 6ak3B-2bq8X:
undetectable		 6ak3B-2bq8X:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens) 		5 / 10 ALA X  98
TYR X 102
PHE X  65
PHE X  52
VAL X  57
 None
 1.37A 6hu9C-2bq8X:
undetectable		 6hu9C-2bq8X:
22.11