SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		3 / 3 ASP A  64
GLU A  20
ARG A  42
 None
 0.75A 1wopA-2bqxA:
undetectable		 1wopA-2bqxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 6 TYR A 140
TYR A  50
TYR A  54
ILE A 133
 None
 1.27A 2xz5A-2bqxA:
undetectable
2xz5B-2bqxA:
undetectable		 2xz5A-2bqxA:
23.77
2xz5B-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 TYR A 140
TYR A  50
TYR A  54
ILE A 133
 None
 1.25A 2xz5B-2bqxA:
undetectable
2xz5E-2bqxA:
undetectable		 2xz5B-2bqxA:
23.77
2xz5E-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ILE A 133
TYR A 140
TYR A  50
TYR A  54
 None
 1.28A 2xz5A-2bqxA:
undetectable
2xz5C-2bqxA:
undetectable		 2xz5A-2bqxA:
23.77
2xz5C-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ILE A 133
TYR A 140
TYR A  50
TYR A  54
 None
 1.27A 2xz5C-2bqxA:
undetectable
2xz5D-2bqxA:
undetectable		 2xz5C-2bqxA:
23.77
2xz5D-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 ILE A 133
TYR A 140
TYR A  50
TYR A  54
 None
 1.26A 2xz5D-2bqxA:
undetectable
2xz5E-2bqxA:
undetectable		 2xz5D-2bqxA:
23.77
2xz5E-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		3 / 3 ARG A  42
GLU A  30
TYR A  54
 None
 0.83A 3k37B-2bqxA:
undetectable		 3k37B-2bqxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		5 / 9 VAL A  68
ILE A 168
ALA A 167
GLU A 165
ALA A  12
 None
 1.00A 3mdvA-2bqxA:
undetectable		 3mdvA-2bqxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		7 / 12 VAL A  68
THR A  60
ILE A 168
ALA A 167
GLU A 165
ALA A 160
ALA A  12
 None
 1.18A 3mdvB-2bqxA:
undetectable		 3mdvB-2bqxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 TYR A 140
TYR A  50
TYR A  54
ILE A 133
 None
 1.30A 4bqtC-2bqxA:
undetectable
4bqtD-2bqxA:
undetectable		 4bqtC-2bqxA:
23.77
4bqtD-2bqxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		5 / 11 SER A   9
VAL A  17
CYH A  16
LEU A  15
ALA A 106
 None
 1.20A 4e0fA-2bqxA:
undetectable		 4e0fA-2bqxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_A_TOYA301_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		5 / 9 GLU A 144
ASP A  41
GLU A  30
ASP A  66
GLU A  97
 None
 1.50A 4ebkA-2bqxA:
0.3
4ebkB-2bqxA:
0.3		 4ebkA-2bqxA:
19.06
4ebkB-2bqxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.15A 4feuB-2bqxA:
undetectable		 4feuB-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.12A 4feuF-2bqxA:
undetectable		 4feuF-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.09A 4fevD-2bqxA:
undetectable		 4fevD-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.09A 4fevF-2bqxA:
undetectable		 4fevF-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.09A 4fewD-2bqxA:
undetectable		 4fewD-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.12A 4fewF-2bqxA:
undetectable		 4fewF-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.15A 4fexB-2bqxA:
undetectable		 4fexB-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.11A 4gkhB-2bqxA:
undetectable		 4gkhB-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.08A 4gkhF-2bqxA:
undetectable		 4gkhF-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 7 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.10A 4gkhG-2bqxA:
undetectable		 4gkhG-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.10A 4gkhC-2bqxA:
undetectable
4gkhK-2bqxA:
undetectable		 4gkhC-2bqxA:
21.35
4gkhK-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.10A 4gkiA-2bqxA:
undetectable		 4gkiA-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.15A 4gkiC-2bqxA:
undetectable		 4gkiC-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 ASP A  41
ASP A 101
GLU A 144
GLU A  30
 None
 1.12A 4gkiE-2bqxA:
undetectable
4gkiG-2bqxA:
undetectable		 4gkiE-2bqxA:
21.35
4gkiG-2bqxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 8 LEU A  73
LEU A 107
ASP A 123
ILE A 122
 None
 0.86A 4lzrA-2bqxA:
undetectable		 4lzrA-2bqxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 4 LEU A  88
TYR A 118
PRO A 108
ILE A 109
 None
 1.15A 5esgA-2bqxA:
undetectable		 5esgA-2bqxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 2bqx INORGANIC
PYROPHOSPHATASE
(Helicobacter
pylori) 		4 / 5 TYR A  50
LYS A  28
GLU A  20
GLY A  55
 None
 1.16A 5jhdJ-2bqxA:
undetectable		 5jhdJ-2bqxA:
23.48