SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 8 LEU A 112
ALA A  99
GLY A 392
VAL A  89
 None
None
FAD  A1485 (-3.4A)
None
 0.79A 1d4sB-2braA:
undetectable		 1d4sB-2braA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 8 MET A 296
PHE A 333
THR A 277
LEU A 273
 None
 1.24A 1ea1A-2braA:
undetectable		 1ea1A-2braA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 4 LEU A 430
PRO A 429
LEU A 433
ARG A 377
 None
 1.44A 1hrkB-2braA:
undetectable		 1hrkB-2braA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 PHE A 333
LEU A 281
LEU A 273
 None
 0.65A 1mx1E-2braA:
undetectable		 1mx1E-2braA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 11 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.03A 2ceoA-2braA:
undetectable		 2ceoA-2braA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 LEU A 430
PRO A 429
LEU A 433
 None
 0.55A 2po5B-2braA:
undetectable		 2po5B-2braA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 4 LEU A 430
PRO A 429
LEU A 433
ARG A 377
 None
 1.38A 2qd2A-2braA:
undetectable		 2qd2A-2braA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 10 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 0.96A 2riwA-2braA:
undetectable
2riwB-2braA:
undetectable		 2riwA-2braA:
21.31
2riwB-2braA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 10 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.04A 2xn6A-2braA:
0.5
2xn6B-2braA:
undetectable		 2xn6A-2braA:
21.89
2xn6B-2braA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 10 GLN A 441
LEU A 442
LEU A 469
ASN A 470
LEU A 439
 None
 1.02A 2xn7A-2braA:
0.4
2xn7B-2braA:
undetectable		 2xn7A-2braA:
21.89
2xn7B-2braA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 LEU A 103
LEU A 106
ALA A 424
LEU A 387
ASP A 212
 None
 1.23A 3gwuA-2braA:
undetectable		 3gwuA-2braA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 9 LEU A 160
VAL A 101
LEU A 460
PHE A 410
VAL A 406
 None
 1.43A 3jwqA-2braA:
undetectable		 3jwqA-2braA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 5 ARG A  98
LEU A 164
VAL A 167
ASP A 134
 None
 0.80A 3ufnA-2braA:
undetectable
3ufnB-2braA:
undetectable		 3ufnA-2braA:
10.50
3ufnB-2braA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 TYR A 144
ASP A 289
ASP A 153
 None
 0.83A 4a6eA-2braA:
undetectable		 4a6eA-2braA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 ASN A 243
LEU A 330
PHE A 294
 None
 0.82A 4dajB-2braA:
undetectable		 4dajB-2braA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 VAL A 167
LEU A 160
PHE A 410
PHE A 130
ARG A  70
 None
 1.24A 4eckA-2braA:
undetectable		 4eckA-2braA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 ALA A  10
GLN A  47
GLY A  43
 None
 0.59A 4odoC-2braA:
undetectable		 4odoC-2braA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 ALA A  20
GLN A 161
GLY A  93
 None
None
FAD  A1485 (-3.4A)
 0.56A 4odoC-2braA:
undetectable		 4odoC-2braA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 ALA A 427
THR A  85
ARG A 385
LEU A 387
LEU A 106
 None
 1.49A 4qzuB-2braA:
0.0		 4qzuB-2braA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 LEU A  97
ALA A  92
VAL A 173
LYS A 166
ALA A 168
 None
 1.19A 4x1iB-2braA:
undetectable		 4x1iB-2braA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 8 ILE A 215
ARG A 377
SER A 374
LEU A 433
MET A 419
 None
 1.42A 4xtaB-2braA:
undetectable		 4xtaB-2braA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 11 ALA A 413
GLY A 392
LEU A 163
LEU A 138
LEU A 135
 None
FAD  A1485 (-3.4A)
None
None
None
 1.08A 4zmeA-2braA:
undetectable		 4zmeA-2braA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 8 GLU A 102
LEU A 460
ARG A  70
LEU A 439
 None
 1.12A 5dxeA-2braA:
undetectable		 5dxeA-2braA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 VAL A 406
GLN A 161
CYH A  95
 None
None
FAD  A1485 (-3.5A)
 0.84A 5icxA-2braA:
undetectable
5icxE-2braA:
undetectable		 5icxA-2braA:
18.38
5icxE-2braA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		3 / 3 VAL A 406
GLN A 161
CYH A  95
 None
None
FAD  A1485 (-3.5A)
 0.90A 5icxC-2braA:
undetectable
5icxF-2braA:
undetectable		 5icxC-2braA:
18.38
5icxF-2braA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 5 ILE A 175
PHE A  30
SER A  41
ALA A 168
 None
 1.20A 5msdA-2braA:
undetectable		 5msdA-2braA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 7 LEU A 162
PHE A 143
PHE A 410
LEU A 164
 None
 1.02A 6aycA-2braA:
undetectable		 6aycA-2braA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 9 ALA A  71
VAL A 101
ALA A 104
VAL A 167
GLY A  44
 None
 0.98A 6bklA-2braA:
undetectable
6bklB-2braA:
undetectable
6bklC-2braA:
undetectable
6bklD-2braA:
undetectable		 6bklA-2braA:
4.13
6bklB-2braA:
4.13
6bklC-2braA:
4.13
6bklD-2braA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 8 GLU A 102
LEU A 460
ARG A  70
LEU A 439
 None
 1.13A 6cbzA-2braA:
undetectable		 6cbzA-2braA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 LEU A  97
VAL A 173
VAL A  89
TRP A 177
LEU A 165
 None
 1.46A 6eliA-2braA:
2.4		 6eliA-2braA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		4 / 6 GLU A 350
ARG A 335
PHE A 351
PRO A 359
 None
 1.42A 6fgdA-2braA:
3.2		 6fgdA-2braA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 VAL A 391
ASP A 289
ARG A 121
GLU A 114
GLY A  91
 None
None
FAD  A1485 (-2.5A)
FAD  A1485 (-2.5A)
FAD  A1485 (-3.3A)
 1.47A 6gnfA-2braA:
3.3		 6gnfA-2braA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS
(Mus
musculus) 		5 / 12 VAL A 391
ASP A 289
ARG A 121
GLU A 114
GLY A  91
 None
None
FAD  A1485 (-2.5A)
FAD  A1485 (-2.5A)
FAD  A1485 (-3.3A)
 1.44A 6gnfC-2braA:
undetectable		 6gnfC-2braA:
23.08