SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 123
SER A 126
LEU A  34
ILE A  12
ALA A  97
 None
None
KJ2  A1214 ( 4.8A)
None
None
 1.48A 2a58A-2breA:
undetectable
2a58E-2breA:
undetectable		 2a58A-2breA:
23.18
2a58E-2breA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  12
ALA A  97
GLY A 123
SER A 126
LEU A  34
 None
None
None
None
KJ2  A1214 ( 4.8A)
 1.47A 2a58C-2breA:
undetectable
2a58D-2breA:
undetectable		 2a58C-2breA:
23.18
2a58D-2breA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 197
ARG A  32
GLU A  28
 None
 0.91A 3qf1A-2breA:
undetectable		 3qf1A-2breA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 161
THR A 159
LEU A 160
GLU A 162
 None
 1.42A 4a3pA-2breA:
undetectable		 4a3pA-2breA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 SER A 138
SER A 140
LEU A  42
THR A 171
 None
None
None
KJ2  A1214 (-4.0A)
 0.91A 4ikjA-2breA:
undetectable
4ikjB-2breA:
undetectable		 4ikjA-2breA:
20.83
4ikjB-2breA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  42
THR A 171
SER A 138
SER A 140
 None
KJ2  A1214 (-4.0A)
None
None
 0.95A 4ikkA-2breA:
undetectable
4ikkB-2breA:
undetectable		 4ikkA-2breA:
20.83
4ikkB-2breA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD401_0
(PROTON-GATED ION
CHANNEL)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 176
ARG A 174
ILE A 147
GLU A 149
 None
 1.31A 4zzcD-2breA:
0.0
4zzcE-2breA:
0.0		 4zzcD-2breA:
20.62
4zzcE-2breA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 SER A  80
LEU A  89
MET A  84
 None
None
KJ2  A1214 (-4.0A)
 0.85A 5ikrB-2breA:
undetectable		 5ikrB-2breA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 201
ILE A 194
ILE A  66
SER A  80
 None
 0.66A 5numA-2breA:
undetectable		 5numA-2breA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  89
GLY A  94
PHE A 128
 None
 0.62A 6exiC-2breA:
undetectable		 6exiC-2breA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 142
ASP A  52
ASP A  79
THR A 171
THR A  58
 None
None
KJ2  A1214 (-2.8A)
KJ2  A1214 (-4.0A)
None
 1.17A 6mn1A-2breA:
0.0		 6mn1A-2breA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 142
ASP A  52
ASP A  79
THR A 171
THR A  58
 None
None
KJ2  A1214 (-2.8A)
KJ2  A1214 (-4.0A)
None
 1.15A 6mn1B-2breA:
0.0		 6mn1B-2breA:
21.71