SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 10 ALA A 124
ASP A   6
ILE A 223
LEU A 167
THR A 120
 None
None
None
None
ANP  A1226 (-4.0A)
 1.40A 1tdrB-2briA:
undetectable		 1tdrB-2briA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 9 ASP A 206
ILE A 214
GLY A 216
VAL A 201
ILE A 202
 None
 1.14A 3d1yB-2briA:
undetectable		 3d1yB-2briA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 167
ILE A 192
ALA A 125
VAL A  11
ASP A   6
 None
 1.18A 3vw1D-2briA:
undetectable		 3vw1D-2briA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 126
PHE A  96
ALA A  39
MET A 111
GLY A 112
 None
 1.22A 4j7xB-2briA:
undetectable		 4j7xB-2briA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 PHE A   5
ALA A  39
LEU A 210
GLY A  43
PHE A  21
 None
None
None
ANP  A1226 (-3.6A)
None
 1.27A 4kykA-2briA:
undetectable
4kykB-2briA:
undetectable		 4kykA-2briA:
23.66
4kykB-2briA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 201
ILE A 223
ILE A 192
ALA A 189
 None
 0.82A 4lv9A-2briA:
undetectable		 4lv9A-2briA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 THR A 221
GLY A 203
ILE A   7
ASP A 206
ALA A 207
 None
 1.16A 5kvaA-2briA:
2.2		 5kvaA-2briA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 THR A 221
GLY A 203
ILE A   7
ASP A 206
ALA A 207
 None
 1.17A 5kvaB-2briA:
4.0		 5kvaB-2briA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 THR A 140
VAL A 138
THR A 199
LEU A 167
SER A 182
 ANP  A1226 (-4.0A)
None
None
None
ANP  A1226 ( 4.0A)
 1.31A 6ak3A-2briA:
0.0		 6ak3A-2briA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 PHE A   5
LEU A  12
GLY A   8
VAL A 213
ILE A 202
 None
None
ANP  A1226 (-3.4A)
None
None
 1.28A 6bxnB-2briA:
3.3		 6bxnB-2briA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 2bri URIDYLATE KINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 209
ILE A 214
GLY A 216
VAL A 201
ILE A 202
 None
 1.12A 6difA-2briA:
undetectable		 6difA-2briA:
20.10