SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bs4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 5 GLY C  43
SER C  49
THR C  50
PHE C  47
 None
 1.29A 1icuC-2bs4C:
undetectable
1icuD-2bs4C:
undetectable		 1icuC-2bs4C:
22.76
1icuD-2bs4C:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 5 GLY C  43
SER C  49
THR C  50
PHE C  47
 None
 1.31A 1icvA-2bs4C:
undetectable
1icvB-2bs4C:
undetectable		 1icvA-2bs4C:
22.76
1icvB-2bs4C:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 5 GLY C  43
SER C  49
THR C  50
PHE C  47
 None
 1.31A 1kqbA-2bs4C:
undetectable
1kqbB-2bs4C:
undetectable		 1kqbA-2bs4C:
23.68
1kqbB-2bs4C:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 4 LEU C 225
LEU C 220
SER C 217
LEU C 181
 None
 1.01A 1ya3A-2bs4C:
0.0		 1ya3A-2bs4C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		3 / 3 ARG C  99
VAL C  89
GLY C  38
 None
None
HEM  C1255 ( 4.2A)
 0.60A 2avvE-2bs4C:
undetectable		 2avvE-2bs4C:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		5 / 12 PHE C  85
GLY C  43
GLY C 186
LEU C 187
LEU C 190
 None
None
HEM  C1255 (-3.4A)
HEM  C1255 (-4.8A)
HEM  C1255 (-4.2A)
 1.07A 2hw2A-2bs4C:
undetectable		 2hw2A-2bs4C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 6 THR C 227
GLY C 229
ARG C 162
LEU C 225
 HEM  C1256 ( 4.4A)
None
HEM  C1256 (-3.8A)
None
 1.20A 4ac9C-2bs4C:
undetectable		 4ac9C-2bs4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 6 THR C 227
GLY C 229
ARG C 162
LEU C 225
 HEM  C1256 ( 4.4A)
None
HEM  C1256 (-3.8A)
None
 1.16A 4acaC-2bs4C:
undetectable		 4acaC-2bs4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		3 / 3 VAL C 232
LEU C 236
VAL C 164
 None
 0.48A 4wq4A-2bs4C:
undetectable		 4wq4A-2bs4C:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 4 LEU C 171
ILE C 146
HIS C 143
VAL C 142
 None
None
HEM  C1256 (-3.2A)
None
 1.25A 4xyzA-2bs4C:
undetectable		 4xyzA-2bs4C:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		3 / 3 HIS C 114
LYS C 115
PHE C 111
 None
 1.28A 5klaA-2bs4C:
undetectable		 5klaA-2bs4C:
20.23