SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 104
ASN A 128
ASP A 132
TYR A  64
 None
 1.21A 1hpkA-2bs9A:
undetectable		 1hpkA-2bs9A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 226
VAL A 260
PHE A 211
VAL A 222
 None
 0.98A 1o86A-2bs9A:
undetectable		 1o86A-2bs9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 TYR A 145
LEU A  90
ILE A  98
ILE A  63
PHE A 141
 None
 1.40A 1q6iA-2bs9A:
undetectable		 1q6iA-2bs9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 THR A 239
GLY A 334
ASP A 291
ALA A 330
 None
 0.91A 1sg9A-2bs9A:
undetectable		 1sg9A-2bs9A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 293
VAL A 475
TRP A 384
 None
 1.00A 1tkqA-2bs9A:
undetectable		 1tkqA-2bs9A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 102
VAL A 114
TRP A 117
 None
None
CA  A1503 (-4.3A)
 0.89A 2cc8A-2bs9A:
undetectable		 2cc8A-2bs9A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 102
VAL A 114
TRP A 117
 None
None
CA  A1503 (-4.3A)
 0.87A 2ccbA-2bs9A:
undetectable		 2ccbA-2bs9A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A  61
TYR A  35
GLY A  28
ASP A  60
THR A  24
 None
 1.49A 2f9wA-2bs9A:
undetectable
2f9wB-2bs9A:
undetectable		 2f9wA-2bs9A:
19.73
2f9wB-2bs9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A 167
PRO A 123
LEU A 107
GLY A 101
 None
 0.98A 2hs2B-2bs9A:
undetectable		 2hs2B-2bs9A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ALA A 340
ASP A 320
ARG A 445
MET A 430
 None
 1.28A 2ouzA-2bs9A:
undetectable		 2ouzA-2bs9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  27
LEU A  56
ILE A  51
ARG A  52
 None
 0.99A 2rlfA-2bs9A:
undetectable
2rlfB-2bs9A:
undetectable		 2rlfA-2bs9A:
7.32
2rlfB-2bs9A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  27
LEU A  56
ILE A  51
ARG A  52
 None
 0.93A 2rlfC-2bs9A:
undetectable
2rlfD-2bs9A:
undetectable		 2rlfC-2bs9A:
7.32
2rlfD-2bs9A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		6 / 12 ASN A 159
GLU A 160
HIS A 228
TYR A 230
GLU A 278
TRP A 316
 None
 0.70A 2v3dA-2bs9A:
21.1		 2v3dA-2bs9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		6 / 12 ASN A 159
GLU A 160
PHE A 115
HIS A 228
GLU A 278
TRP A 316
 None
 0.82A 2v3dA-2bs9A:
21.1		 2v3dA-2bs9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 ASN A 159
GLU A 160
PHE A 115
GLU A 278
TRP A 316
 None
 0.80A 2v3dB-2bs9A:
19.6		 2v3dB-2bs9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 ASN A 159
GLU A 160
TYR A 230
GLU A 278
TRP A 316
 None
 0.72A 2v3dB-2bs9A:
19.6		 2v3dB-2bs9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 102
VAL A 114
TRP A 117
 None
None
CA  A1503 (-4.3A)
 0.86A 2vx9A-2bs9A:
undetectable		 2vx9A-2bs9A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 230
GLU A 160
ASN A 165
 None
 0.90A 2y7hC-2bs9A:
undetectable		 2y7hC-2bs9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASP A 311
VAL A 260
ARG A 261
ILE A 264
 None
 0.98A 2yfbA-2bs9A:
0.0		 2yfbA-2bs9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A 311
VAL A 260
ARG A 261
ILE A 264
 None
 0.99A 2yfbB-2bs9A:
undetectable		 2yfbB-2bs9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 343
GLU A  44
ASP A  37
 None
 0.82A 2zthA-2bs9A:
undetectable		 2zthA-2bs9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 ARG A  95
PRO A  96
TYR A  50
VAL A  86
 None
 0.99A 3sufC-2bs9A:
undetectable		 3sufC-2bs9A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  55
GLY A  53
GLU A 160
LEU A 163
VAL A 114
 None
 1.25A 3t7vA-2bs9A:
5.6		 3t7vA-2bs9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 296
ASN A 473
ILE A 302
VAL A 382
VAL A 475
 None
 1.07A 3ucbA-2bs9A:
undetectable		 3ucbA-2bs9A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 302
ILE A 276
TYR A 279
GLU A 278
 None
 0.87A 4a99D-2bs9A:
undetectable		 4a99D-2bs9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 276
LEU A 163
ILE A 200
CYH A 201
 None
 0.86A 4asdA-2bs9A:
undetectable		 4asdA-2bs9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A  99
GLU A 160
GLU A 324
TYR A 279
 None
 0.85A 4mj8A-2bs9A:
undetectable
4mj8C-2bs9A:
undetectable		 4mj8A-2bs9A:
18.98
4mj8C-2bs9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  61
LEU A  29
GLY A  28
ASP A  60
THR A  24
 None
 1.18A 4o5fA-2bs9A:
1.3
4o5fB-2bs9A:
undetectable		 4o5fA-2bs9A:
19.77
4o5fB-2bs9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A  24
VAL A  61
LEU A  29
GLY A  28
ASP A  60
 None
 1.16A 4o5fA-2bs9A:
1.3
4o5fB-2bs9A:
undetectable		 4o5fA-2bs9A:
19.77
4o5fB-2bs9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 336
HIS A  54
TYR A 230
GLU A 278
 None
 1.13A 4pahA-2bs9A:
undetectable		 4pahA-2bs9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 107
VAL A 137
ILE A 134
ILE A  63
GLY A  62
 None
 0.96A 4y8wC-2bs9A:
undetectable		 4y8wC-2bs9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  61
LEU A  29
GLY A  28
ASP A  60
THR A  24
 None
 1.15A 5b8hA-2bs9A:
1.7
5b8hB-2bs9A:
undetectable		 5b8hA-2bs9A:
19.81
5b8hB-2bs9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A  24
VAL A  61
LEU A  29
GLY A  28
ASP A  60
 None
 1.14A 5b8hA-2bs9A:
undetectable
5b8hB-2bs9A:
undetectable		 5b8hA-2bs9A:
19.81
5b8hB-2bs9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A  23
THR A  24
SER A 314
VAL A  22
 None
 1.12A 5ewuB-2bs9A:
undetectable		 5ewuB-2bs9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A  98
GLY A  53
THR A  24
LEU A  27
PHE A 141
 None
 0.94A 5fhzC-2bs9A:
undetectable		 5fhzC-2bs9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  57
ILE A  63
GLY A  62
LYS A 105
LEU A  27
 None
 0.78A 5twjC-2bs9A:
undetectable		 5twjC-2bs9A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 MET A 369
ASN A 473
VAL A 475
LEU A 383
 None
 1.42A 5xdhD-2bs9A:
0.0		 5xdhD-2bs9A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 ASP A  87
TYR A 145
VAL A 150
ALA A 183
VAL A 137
 None
 1.38A 6hu9A-2bs9A:
undetectable
6hu9E-2bs9A:
undetectable
6hu9I-2bs9A:
undetectable		 6hu9A-2bs9A:
21.16
6hu9E-2bs9A:
17.74
6hu9I-2bs9A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2bs9 BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 ASP A  87
TYR A 145
VAL A 150
ALA A 183
VAL A 137
 None
 1.37A 6hu9L-2bs9A:
undetectable
6hu9P-2bs9A:
undetectable
6hu9T-2bs9A:
undetectable		 6hu9L-2bs9A:
21.16
6hu9P-2bs9A:
17.74
6hu9T-2bs9A:
7.85