SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 10 LEU A  79
ASN A  77
VAL A 128
GLY A 129
LEU A  60
 None
 1.46A 1fkoA-2bszA:
undetectable		 1fkoA-2bszA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		3 / 3 ASN A  44
PHE A 264
VAL A 208
 None
 0.80A 1kijA-2bszA:
undetectable		 1kijA-2bszA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 11 LEU A 181
GLY A  92
GLY A  93
ILE A 125
TYR A 124
 None
 1.13A 1p91A-2bszA:
undetectable		 1p91A-2bszA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 11 GLY A  50
ILE A 258
ALA A 247
VAL A 208
ILE A 273
 None
 1.14A 2nnhA-2bszA:
undetectable		 2nnhA-2bszA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 11 GLY A 131
PHE A  42
PHE A 204
HIS A 203
ILE A 209
 None
 1.30A 2y7kA-2bszA:
undetectable		 2y7kA-2bszA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 10 GLY A 131
PHE A  42
PHE A 204
HIS A 203
ILE A 209
 None
 1.31A 2y7kB-2bszA:
undetectable		 2y7kB-2bszA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 7 GLY A 131
PHE A  42
PHE A 204
HIS A 203
ILE A 209
 None
 1.31A 2y7wC-2bszA:
undetectable		 2y7wC-2bszA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 12 SER A 111
HIS A 203
GLY A 129
GLY A 131
ASN A  77
 None
 1.38A 3f8wB-2bszA:
undetectable		 3f8wB-2bszA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 6 PHE A  42
TYR A  72
CYH A  73
VAL A  98
PHE A 204
 None
 0.42A 3ltwA-2bszA:
38.8		 3ltwA-2bszA:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		4 / 6 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 None
 0.32A 3ltwA-2bszA:
38.8		 3ltwA-2bszA:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		4 / 6 GLY A 171
TRP A 173
GLU A 146
ARG A 155
 None
 1.24A 4bqfA-2bszA:
undetectable		 4bqfA-2bszA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 12 ILE A  45
ALA A 211
THR A 271
ILE A 273
LEU A 246
 None
 1.04A 4kjjA-2bszA:
undetectable		 4kjjA-2bszA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		4 / 6 SER A  25
LEU A  26
ASP A  27
LEU A 119
 None
 0.37A 4wozA-2bszA:
undetectable
4wozB-2bszA:
undetectable		 4wozA-2bszA:
20.86
4wozB-2bszA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 12 ALA A 211
PRO A  41
GLY A 129
GLY A  71
LEU A 114
 None
 1.06A 5c0oH-2bszA:
undetectable		 5c0oH-2bszA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		4 / 6 PRO A 138
GLU A 186
ALA A  86
LEU A   9
 None
 1.07A 5igiA-2bszA:
undetectable		 5igiA-2bszA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 9 VAL A 268
LEU A 246
ALA A 247
VAL A 208
ILE A 273
 None
 1.08A 5om2A-2bszA:
undetectable
5om2B-2bszA:
undetectable		 5om2A-2bszA:
13.21
5om2B-2bszA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		6 / 12 LEU A   9
ALA A  83
GLU A 186
VAL A  91
LEU A  78
GLY A  88
 None
 1.40A 5vcvA-2bszA:
undetectable		 5vcvA-2bszA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1
(Mesorhizobium
loti) 		5 / 12 ALA A 126
LEU A 115
VAL A 117
GLY A  88
LEU A  13
 None
 1.13A 5x24A-2bszA:
undetectable		 5x24A-2bszA:
19.47