SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bt7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FAK_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	2bt7	SIGMA C (Avian orthoreovirus)	5 / 10	LEU A 237 ILE A 214 GLY A 235 THR A 281 PHE A 280	None	0.97A	4fakA-2bt7A: undetectable	4fakA-2bt7A: 16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_A_DGXA1107_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	2bt7	SIGMA C (Avian orthoreovirus)	5 / 12	ASP A 325 LEU A 250 PHE A 301 ALA A 272 PHE A 274	None	0.98A	4retA-2bt7A: undetectable	4retA-2bt7A: 9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A94_A_ZOTA3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	2bt7	SIGMA C (Avian orthoreovirus)	5 / 12	LEU A 237 VAL A 239 GLY A 209 PHE A 305 VAL A 278	None	1.19A	6a94A-2bt7A: undetectable	6a94A-2bt7A: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A94_B_ZOTB3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	2bt7	SIGMA C (Avian orthoreovirus)	5 / 12	LEU A 237 VAL A 239 GLY A 209 PHE A 305 VAL A 278	None	1.20A	6a94B-2bt7A: undetectable	6a94B-2bt7A: 19.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4FAK_A_SAMA201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","2bt7","SIGMA C","Avian orthoreovirus",5,"LEU A 237;ILE A 214;GLY A 235;THR A 281;PHE A 280","None","0.97A","4fakA-2bt7A:undetectable","4fakA-2bt7A:16.95"],["4RET_A_DGXA1107_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","2bt7","SIGMA C","Avian orthoreovirus",5,"ASP A 325;LEU A 250;PHE A 301;ALA A 272;PHE A 274","None","0.98A","4retA-2bt7A:undetectable","4retA-2bt7A:9.86"],["6A94_A_ZOTA3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","2bt7","SIGMA C","Avian orthoreovirus",5,"LEU A 237;VAL A 239;GLY A 209;PHE A 305;VAL A 278","None","1.19A","6a94A-2bt7A:undetectable","6a94A-2bt7A:19.67"],["6A94_B_ZOTB3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","2bt7","SIGMA C","Avian orthoreovirus",5,"LEU A 237;VAL A 239;GLY A 209;PHE A 305;VAL A 278","None","1.20A","6a94B-2bt7A:undetectable","6a94B-2bt7A:19.67"]]