SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2btd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 ALA A 123
VAL A 117
TRP A 134
 ADP  A1211 ( 4.4A)
None
None
 0.93A 1av2A-2btdA:
undetectable
1av2B-2btdA:
undetectable		 1av2A-2btdA:
7.52
1av2B-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 TRP A 134
ALA A 123
VAL A 117
 None
ADP  A1211 ( 4.4A)
None
 0.88A 1av2C-2btdA:
undetectable
1av2D-2btdA:
undetectable		 1av2C-2btdA:
7.52
1av2D-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 5 GLU A 105
LEU A   3
LEU A 101
LEU A 103
 None
 0.88A 1np1A-2btdA:
undetectable		 1np1A-2btdA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 ALA A 123
VAL A 117
TRP A 134
 ADP  A1211 ( 4.4A)
None
None
 0.90A 1w5uA-2btdA:
undetectable
1w5uB-2btdA:
undetectable		 1w5uA-2btdA:
7.52
1w5uB-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 TRP A 134
ALA A 123
VAL A 117
 None
ADP  A1211 ( 4.4A)
None
 0.92A 1w5uA-2btdA:
undetectable
1w5uB-2btdA:
undetectable		 1w5uA-2btdA:
7.52
1w5uB-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 ALA A 123
VAL A 117
TRP A 134
 ADP  A1211 ( 4.4A)
None
None
 0.91A 2izqA-2btdA:
undetectable
2izqB-2btdA:
undetectable		 2izqA-2btdA:
7.52
2izqB-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 TRP A 134
ALA A 123
VAL A 117
 None
ADP  A1211 ( 4.4A)
None
 0.96A 2izqC-2btdA:
undetectable
2izqD-2btdA:
undetectable		 2izqC-2btdA:
7.52
2izqD-2btdA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 12 SER A 196
LEU A  72
GLY A  85
PHE A  84
VAL A  49
 None
 1.21A 2kceB-2btdA:
undetectable		 2kceB-2btdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 8 ALA A  91
ILE A  89
GLY A  62
ILE A  64
LEU A  72
 None
 1.21A 2o4nB-2btdA:
undetectable		 2o4nB-2btdA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 7 VAL A  76
GLY A  78
ALA A  79
LEU A  83
 None
ADP  A1211 (-3.5A)
ADP  A1211 (-3.5A)
ADP  A1211 (-4.5A)
 0.90A 2wekB-2btdA:
undetectable		 2wekB-2btdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 12 THR A 195
ASP A 191
ASP A  37
GLY A  78
VAL A  76
 None
ADP  A1211 (-2.5A)
ADP  A1211 (-2.5A)
ADP  A1211 (-3.5A)
None
 1.38A 3hiiA-2btdA:
0.0		 3hiiA-2btdA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 12 THR A 195
ASP A 191
ASP A  37
GLY A  78
VAL A  76
 None
ADP  A1211 (-2.5A)
ADP  A1211 (-2.5A)
ADP  A1211 (-3.5A)
None
 1.38A 3hiiB-2btdA:
0.0		 3hiiB-2btdA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 7 GLY A 113
CYH A  15
PHE A  88
GLY A  85
 None
 0.92A 3ko0M-2btdA:
0.0
3ko0P-2btdA:
undetectable		 3ko0M-2btdA:
19.43
3ko0P-2btdA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 7 PHE A  88
GLY A  85
GLY A 113
CYH A  15
 None
 0.91A 3ko0M-2btdA:
0.0
3ko0P-2btdA:
undetectable		 3ko0M-2btdA:
19.43
3ko0P-2btdA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 8 GLY A  16
PHE A  46
ILE A  64
PHE A  87
 None
 0.91A 3ko0O-2btdA:
undetectable
3ko0Q-2btdA:
undetectable		 3ko0O-2btdA:
19.43
3ko0Q-2btdA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 TRP A 134
ALA A 123
VAL A 117
 None
ADP  A1211 ( 4.4A)
None
 1.00A 3l8lC-2btdA:
undetectable
3l8lD-2btdA:
undetectable		 3l8lC-2btdA:
7.52
3l8lD-2btdA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 10 LEU A 101
ALA A  91
GLY A  62
ILE A  61
CYH A  15
 None
 1.38A 3qpsA-2btdA:
undetectable		 3qpsA-2btdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		3 / 3 ALA A 194
GLN A 167
THR A 169
 None
 0.76A 5n0oA-2btdA:
undetectable		 5n0oA-2btdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 7 GLY A 126
SER A 164
THR A 129
ALA A 194
 None
None
ADP  A1211 (-3.6A)
None
 0.79A 5o96C-2btdA:
undetectable		 5o96C-2btdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		4 / 6 THR A 195
ASP A 191
LEU A  29
ASP A  30
 None
ADP  A1211 (-2.5A)
None
MG  A1212 ( 2.3A)
 1.10A 5tdzA-2btdA:
undetectable		 5tdzA-2btdA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 12 GLN A 190
ALA A 194
GLU A  22
LEU A  29
PHE A  19
 None
 1.38A 5vlmA-2btdA:
undetectable		 5vlmA-2btdA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE
(Escherichia
coli) 		5 / 12 VAL A 137
VAL A 138
LEU A   3
MET A 201
LEU A 204
 None
 1.13A 6b52A-2btdA:
undetectable		 6b52A-2btdA:
22.83