SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2btm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 182
TYR A 165
ASP A 181
GLY A 174
GLU A 128
 None
 1.45A 1agmA-2btmA:
undetectable		 1agmA-2btmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 182
TYR A 165
ASP A 181
GLY A 174
GLU A 128
 None
 1.45A 1agmA-2btmA:
undetectable		 1agmA-2btmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		3 / 4 LYS A 111
ALA A 114
MET A  65
 None
 0.96A 1hk3A-2btmA:
undetectable		 1hk3A-2btmA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A   7
ALA A   6
VAL A 162
GLY A 210
ILE A 123
 None
 0.94A 1hsgB-2btmA:
undetectable		 1hsgB-2btmA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 243
SER A 241
PHE A 242
ALA A 235
 None
 0.67A 1j8uA-2btmA:
undetectable		 1j8uA-2btmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A  62
VAL A  39
TRP A   9
 None
 0.85A 1kqeA-2btmA:
undetectable
1kqeE-2btmA:
undetectable		 1kqeA-2btmA:
7.41
1kqeE-2btmA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A  62
VAL A  39
TRP A   9
 None
 0.84A 1kqeB-2btmA:
undetectable
1kqeD-2btmA:
undetectable		 1kqeB-2btmA:
7.41
1kqeD-2btmA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A   9
ALA A  62
VAL A  39
 None
 0.83A 1kqeB-2btmA:
undetectable
1kqeD-2btmA:
undetectable		 1kqeB-2btmA:
7.41
1kqeD-2btmA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A   9
ALA A  62
VAL A  39
 None
 0.82A 1kqeA-2btmA:
undetectable
1kqeE-2btmA:
undetectable		 1kqeA-2btmA:
7.41
1kqeE-2btmA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A 164
GLY A 233
GLU A 166
ILE A 123
HIS A  94
 None
PGA  A 301 (-3.2A)
PGA  A 301 (-2.9A)
None
PGA  A 301 (-3.8A)
 1.18A 1pg2A-2btmA:
undetectable		 1pg2A-2btmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  58
VAL A  39
PHE A 242
VAL A  29
ALA A   6
 None
 1.17A 1q23H-2btmA:
undetectable
1q23I-2btmA:
undetectable		 1q23H-2btmA:
20.23
1q23I-2btmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A   7
ALA A   6
VAL A 162
GLY A 210
ILE A 123
 None
 0.99A 1sdtB-2btmA:
undetectable		 1sdtB-2btmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 182
TYR A 165
ASP A 181
GLY A 174
GLU A 128
 None
 1.44A 2f6dA-2btmA:
undetectable		 2f6dA-2btmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  77
ASN A   8
ILE A  91
VAL A  38
LEU A  46
 None
PGA  A 301 (-4.6A)
None
None
None
 1.28A 2ft9A-2btmA:
undetectable		 2ft9A-2btmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A 164
ALA A 230
GLY A 233
GLU A 166
ILE A 123
HIS A  94
 None
None
PGA  A 301 (-3.2A)
PGA  A 301 (-2.9A)
None
PGA  A 301 (-3.8A)
 1.07A 2x1lA-2btmA:
undetectable		 2x1lA-2btmA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A 164
ALA A 230
GLY A 233
GLU A 166
ILE A 123
HIS A  94
 None
None
PGA  A 301 (-3.2A)
PGA  A 301 (-2.9A)
None
PGA  A 301 (-3.8A)
 1.05A 2x1lB-2btmA:
undetectable		 2x1lB-2btmA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A 164
ALA A 230
GLY A 233
GLU A 166
ILE A 123
HIS A  94
 None
None
PGA  A 301 (-3.2A)
PGA  A 301 (-2.9A)
None
PGA  A 301 (-3.8A)
 1.06A 2x1lC-2btmA:
undetectable		 2x1lC-2btmA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 8 GLY A   7
ALA A   6
VAL A 162
GLY A 210
ILE A 123
 None
 1.07A 3ekpA-2btmA:
undetectable		 3ekpA-2btmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 153
GLY A 198
ALA A 202
ILE A 163
 None
 0.84A 3jusA-2btmA:
undetectable		 3jusA-2btmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 153
GLY A 198
ALA A 202
ILE A 163
 None
 0.84A 3jusA-2btmA:
undetectable		 3jusA-2btmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A   7
ALA A   6
VAL A 162
GLY A 210
ILE A 123
 None
 0.93A 3jvyA-2btmA:
undetectable		 3jvyA-2btmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLY A 211
ILE A  91
CYH A  40
PHE A  21
GLY A 234
 PGA  A 301 (-3.5A)
None
None
None
PGA  A 301 (-3.8A)
 1.35A 3ko0A-2btmA:
undetectable
3ko0C-2btmA:
undetectable		 3ko0A-2btmA:
16.05
3ko0C-2btmA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 10 GLY A 211
ILE A  91
CYH A  40
PHE A  21
GLY A 234
 PGA  A 301 (-3.5A)
None
None
None
PGA  A 301 (-3.8A)
 1.29A 3ko0R-2btmA:
0.0
3ko0T-2btmA:
undetectable		 3ko0R-2btmA:
16.05
3ko0T-2btmA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 229
TYR A 209
ALA A 164
GLU A 166
 None
None
None
PGA  A 301 (-2.9A)
 0.81A 3u9hA-2btmA:
undetectable		 3u9hA-2btmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 229
TYR A 209
ALA A 164
GLU A 166
 None
None
None
PGA  A 301 (-2.9A)
 0.80A 3u9hB-2btmA:
undetectable		 3u9hB-2btmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  92
ALA A 149
VAL A 193
ILE A 124
 None
 0.87A 3wsjB-2btmA:
undetectable		 3wsjB-2btmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 132
GLY A 127
TYR A 209
VAL A 185
ALA A 182
 None
 1.18A 4foxD-2btmA:
undetectable		 4foxD-2btmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 153
ALA A 161
VAL A 162
ALA A 149
 None
 0.80A 4g77A-2btmA:
undetectable		 4g77A-2btmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A  43
MET A  65
LEU A  85
LEU A  46
 None
 1.22A 5dzke-2btmA:
undetectable
5dzks-2btmA:
undetectable		 5dzke-2btmA:
23.74
5dzks-2btmA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  92
ALA A 149
ILE A 163
VAL A 193
ILE A 124
 None
 0.90A 5t8hB-2btmA:
undetectable		 5t8hB-2btmA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 138
ARG A 133
ILE A 168
GLU A 166
 None
None
None
PGA  A 301 (-2.9A)
 1.07A 5uigA-2btmA:
undetectable		 5uigA-2btmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  46
GLY A  86
VAL A  19
VAL A  22
ILE A  60
 None
 1.06A 6emuB-2btmA:
undetectable		 6emuB-2btmA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  46
GLY A  86
VAL A  19
VAL A  22
ILE A  60
 None
 1.03A 6emuC-2btmA:
undetectable		 6emuC-2btmA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A   9
GLU A 238
GLU A  17
 None
 0.72A 6fhwA-2btmA:
undetectable		 6fhwA-2btmA:
16.12