SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2btu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.53A 1q23C-2btuA:
undetectable		 1q23C-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.50A 1q23H-2btuA:
undetectable		 1q23H-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.57A 1q23G-2btuA:
undetectable		 1q23G-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.61A 1q23L-2btuA:
undetectable		 1q23L-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.52A 1q23J-2btuA:
undetectable		 1q23J-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		5 / 12 LEU A 181
ILE A 179
VAL A 241
GLY A 243
LEU A 235
 None
 1.23A 2bxeB-2btuA:
undetectable		 2bxeB-2btuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		4 / 5 LEU A  68
ILE A 119
ILE A 106
ALA A 107
 None
 0.72A 2i2zA-2btuA:
undetectable		 2i2zA-2btuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		4 / 4 LEU A  68
ILE A 119
ILE A 106
ALA A 107
 None
 0.79A 2i30A-2btuA:
undetectable		 2i30A-2btuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		3 / 3 PHE A 252
SER A 183
LEU A 181
 None
 0.74A 2w1bA-2btuA:
3.4		 2w1bA-2btuA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		5 / 11 VAL A  26
LEU A 134
THR A 139
ASP A 104
VAL A 120
 None
 1.19A 2z9xB-2btuA:
undetectable		 2z9xB-2btuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		5 / 11 GLN A 276
LEU A 181
ALA A 245
PHE A 252
PHE A 294
 None
 1.43A 3n23C-2btuA:
undetectable		 3n23C-2btuA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		5 / 12 ILE A 123
LEU A  68
GLY A 155
ILE A 106
ALA A 107
 None
 1.02A 3uwlB-2btuA:
undetectable		 3uwlB-2btuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		4 / 7 GLY A  81
THR A  79
ILE A  82
THR A  28
 None
 0.92A 4acaC-2btuA:
undetectable		 4acaC-2btuA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIS_A_DAHA24_1
(POLYSACCHARIDE
MONOOXYGENASE-3)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		4 / 5 TYR A 228
PRO A 231
ASN A  90
PRO A  99
 None
 1.42A 4eisA-2btuA:
0.0
4eisB-2btuA:
0.0		 4eisA-2btuA:
18.26
4eisB-2btuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		4 / 5 GLY A 169
LEU A 178
ILE A 264
LEU A 236
 None
 0.84A 4o8fA-2btuA:
undetectable		 4o8fA-2btuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE
(Bacillus
anthracis) 		5 / 12 ILE A 123
LEU A  68
GLY A 155
ILE A 106
ALA A 107
 None
 1.09A 5j7wD-2btuA:
undetectable		 5j7wD-2btuA:
23.56