SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2btv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 7 TYR P 271
THR P 309
SER P 306
TRP P 278
 None
 1.41A 1eiiA-2btvP:
undetectable		 1eiiA-2btvP:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ILE A 595
LEU A 598
VAL A 602
 None
 0.40A 1mz9B-2btvA:
undetectable		 1mz9B-2btvA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 10 GLY P  78
VAL P  77
LEU P  70
LEU P  66
ALA P 284
 None
 1.40A 1pbcA-2btvP:
undetectable		 1pbcA-2btvP:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 ILE P 174
ILE P 159
PHE P 129
ILE P 245
LEU P 186
 None
 0.95A 1qhsA-2btvP:
undetectable		 1qhsA-2btvP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 ILE P 174
ILE P 159
PHE P 129
ILE P 245
LEU P 186
 None
 0.91A 1qhyA-2btvP:
undetectable		 1qhyA-2btvP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 LEU P 310
LEU P 313
LEU P 316
ALA P 317
ILE P 267
 None
 0.56A 1s9pC-2btvP:
undetectable		 1s9pC-2btvP:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 11 VAL A 861
VAL A 101
ARG A 103
LEU A 867
ILE A 866
 None
 1.30A 1t6zA-2btvA:
undetectable		 1t6zA-2btvA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 5 VAL A 375
GLY A 374
VAL A 376
TRP A 573
 None
 1.13A 1tkqB-2btvA:
undetectable		 1tkqB-2btvA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 GLN P 124
ILE P 251
TYR P 250
 None
 0.71A 1vifA-2btvP:
undetectable		 1vifA-2btvP:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 CYH A 209
TYR A 108
ARG A 872
TYR A 107
 None
 1.07A 1xqlA-2btvA:
undetectable
1xqlB-2btvA:
undetectable		 1xqlA-2btvA:
19.40
1xqlB-2btvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 TYR A 108
ARG A 872
TYR A 107
CYH A 209
 None
 1.08A 1xqlA-2btvA:
undetectable
1xqlB-2btvA:
undetectable		 1xqlA-2btvA:
19.40
1xqlB-2btvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 ILE A 429
ALA A 506
LEU A 504
LEU A 402
PHE A 427
 None
 1.25A 1xzxX-2btvA:
undetectable		 1xzxX-2btvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 LEU A 242
HIS A 539
LYS A 246
 None
 1.11A 1y7iA-2btvA:
undetectable		 1y7iA-2btvA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 ARG P 288
VAL P 270
LEU P 316
VAL P  77
 None
 1.03A 2bdmA-2btvP:
undetectable		 2bdmA-2btvP:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 ASN P 179
PHE P 129
PHE P 175
PRO P 181
TYR P 250
 None
 1.47A 2f38A-2btvP:
0.0		 2f38A-2btvP:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 7 THR P 102
GLU P 108
VAL P 319
MET P  61
 None
 1.17A 2fb2B-2btvP:
undetectable		 2fb2B-2btvP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ARG A 722
ARG A 100
ARG A 720
 None
 1.16A 2jb7A-2btvA:
undetectable
2jb7B-2btvA:
undetectable
2jb7C-2btvA:
undetectable		 2jb7A-2btvA:
10.71
2jb7B-2btvA:
10.71
2jb7C-2btvA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 TYR A 515
LEU A 314
LEU A 379
LEU A 501
TYR A 497
 None
 1.37A 2prgB-2btvA:
undetectable		 2prgB-2btvA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 5 ARG A 215
ALA A 690
ASP A 696
GLU A 211
 None
 1.49A 2xrzA-2btvA:
undetectable		 2xrzA-2btvA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 ILE A 429
TYR A 405
VAL A 505
CYH A 436
 None
 1.26A 2xz5A-2btvA:
undetectable
2xz5C-2btvA:
undetectable		 2xz5A-2btvA:
13.74
2xz5C-2btvA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 ILE A 429
TYR A 405
VAL A 505
CYH A 436
 None
 1.25A 2xz5C-2btvA:
undetectable
2xz5D-2btvA:
undetectable		 2xz5C-2btvA:
13.74
2xz5D-2btvA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 6 ILE A 483
ARG A 247
PRO A 899
VAL A  61
 None
 1.02A 2ygoA-2btvA:
undetectable		 2ygoA-2btvA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 5 VAL P 270
THR P 321
THR P 283
ARG P 286
 None
 1.17A 3bjwG-2btvP:
undetectable		 3bjwG-2btvP:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 SER A 540
ASN A 292
PHE A 542
TRP A 279
 None
 1.31A 3n62A-2btvA:
undetectable		 3n62A-2btvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ASN P 269
ALA P 317
ARG P 274
 None
 0.74A 3tj7C-2btvP:
undetectable
3tj7D-2btvP:
undetectable		 3tj7C-2btvP:
20.86
3tj7D-2btvP:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 9 ILE P 222
ILE P 184
PHE P 175
PHE P 129
VAL P 248
 None
 1.37A 4afgA-2btvP:
0.0
4afgE-2btvP:
0.0		 4afgA-2btvP:
18.44
4afgE-2btvP:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 6 ALA A 564
GLY A 351
PRO A 350
LEU A 544
 None
 1.07A 4dubA-2btvA:
undetectable		 4dubA-2btvA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 TYR A 515
LEU A 314
LEU A 379
LEU A 501
TYR A 497
 None
 1.33A 4emaA-2btvA:
undetectable		 4emaA-2btvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 7 TYR P  40
VAL P  11
ILE P  99
ILE P  35
 None
 0.93A 4lv9B-2btvP:
undetectable		 4lv9B-2btvP:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ASP P  67
LEU P  66
PHE P  63
 None
 0.34A 4pthA-2btvP:
undetectable		 4pthA-2btvP:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 TYR A 410
GLY A 322
PRO A 323
 None
 0.51A 4qwpA-2btvA:
undetectable		 4qwpA-2btvA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 6 TYR A 250
GLU A 600
TRP A 238
LEU A 239
 None
 1.34A 4qzuC-2btvA:
undetectable		 4qzuC-2btvA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 THR A 331
ILE A 326
LEU A 576
ILE A 343
 None
 0.88A 4r38D-2btvA:
undetectable		 4r38D-2btvA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 9 VAL P 270
LEU P 308
ARG P 286
THR P 289
ILE P  75
 None
 1.09A 4ubsA-2btvP:
undetectable		 4ubsA-2btvP:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2btv PROTEIN (VP3 CORE
PROTEIN)
PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 LEU P  18
ALA P  14
ASN P  28
THR A 445
ALA P  36
 None
 1.20A 4x1kA-2btvP:
undetectable
4x1kB-2btvP:
undetectable		 4x1kA-2btvP:
21.35
4x1kB-2btvP:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 8 ILE A 354
LEU A 576
LEU A 380
MET A 394
 None
 0.89A 4xtaB-2btvA:
undetectable		 4xtaB-2btvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 5 ALA A 514
TYR A 515
PRO A 521
PHE A 580
 None
 1.19A 4ze2A-2btvA:
undetectable		 4ze2A-2btvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 6 LEU A 406
ILE A 429
ALA A 506
ALA A 513
 None
 0.77A 4zf8A-2btvA:
undetectable		 4zf8A-2btvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 4 VAL A 227
ALA A 268
ILE A 886
THR A 887
 None
 1.14A 5e4dB-2btvA:
undetectable		 5e4dB-2btvA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 4 ASP A 203
GLY A 195
ASP A 201
ASP A 262
 None
 1.14A 5e72A-2btvA:
undetectable		 5e72A-2btvA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ASP P 275
LEU P  55
ARG P  58
 None
 0.75A 5e8qA-2btvP:
undetectable		 5e8qA-2btvP:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2btv PROTEIN (VP3 CORE
PROTEIN)
PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 LEU P  18
ALA P  14
THR A 447
ILE P  37
ALA P  36
 None
 1.00A 5eypB-2btvP:
undetectable		 5eypB-2btvP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2btv PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 LEU P  18
ALA P  14
ASN P  28
ILE P  37
ALA P  36
 None
 1.21A 5eypB-2btvP:
undetectable		 5eypB-2btvP:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 11 TYR A 217
VAL A  83
ILE A  82
ILE A 264
ILE A 192
 None
 0.99A 5hw8A-2btvA:
undetectable
5hw8D-2btvA:
undetectable		 5hw8A-2btvA:
8.54
5hw8D-2btvA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ALA A 650
ASN A 653
LEU A 654
 None
 0.48A 5i1nC-2btvA:
undetectable		 5i1nC-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ALA A 650
ASN A 653
LEU A 654
 None
 0.25A 5i1nB-2btvA:
undetectable		 5i1nB-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ALA A 650
ASN A 653
LEU A 654
 None
 0.33A 5i1oC-2btvA:
undetectable		 5i1oC-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ALA A 650
ASN A 653
LEU A 654
 None
 0.26A 5i1oA-2btvA:
undetectable		 5i1oA-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ALA A 650
ASN A 653
LEU A 654
 None
 0.34A 5i1pA-2btvA:
undetectable		 5i1pA-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 ALA A 650
ASN A 653
LEU A 654
 None
 0.26A 5i1pD-2btvA:
undetectable		 5i1pD-2btvA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 GLY A 374
LEU A 402
HIS A 378
 None
 0.58A 5u63A-2btvA:
undetectable		 5u63A-2btvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 GLY A 374
LEU A 402
HIS A 378
 None
 0.59A 5u63B-2btvA:
undetectable		 5u63B-2btvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 LEU A 239
SER A 601
ILE A 599
GLU A 594
THR A 295
 None
 1.46A 5w8aA-2btvA:
undetectable		 5w8aA-2btvA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2btv PROTEIN (VP3 CORE
PROTEIN)
PROTEIN (VP7 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 LEU P  18
ALA P  14
THR A 447
ILE P  37
ALA P  36
 None
 0.94A 5xiwB-2btvP:
undetectable		 5xiwB-2btvP:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		3 / 3 TYR A 418
ASN A 403
LEU A 407
 None
 0.81A 6b58A-2btvA:
0.0		 6b58A-2btvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 VAL A 742
ARG A 763
ILE A 765
ASP A 767
ASP A 768
 None
 1.32A 6bxnA-2btvA:
undetectable		 6bxnA-2btvA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 4 ILE A 131
LEU A 697
HIS A 616
ALA A 691
 None
 0.99A 6ck2C-2btvA:
undetectable
6ck2D-2btvA:
undetectable		 6ck2C-2btvA:
4.31
6ck2D-2btvA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		4 / 5 ALA A 268
TYR A  80
GLN A 228
ILE A 224
 None
 1.14A 6g9bA-2btvA:
undetectable
6g9bB-2btvA:
undetectable		 6g9bA-2btvA:
6.83
6g9bB-2btvA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 TYR A 217
VAL A  83
ILE A  82
ILE A 264
ILE A 192
 None
 1.06A 6mkeA-2btvA:
undetectable
6mkeD-2btvA:
undetectable		 6mkeA-2btvA:
5.76
6mkeD-2btvA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2btv PROTEIN (VP3 CORE
PROTEIN)
(Bluetongue
virus) 		5 / 12 TYR A 217
VAL A  83
ILE A  82
ILE A 264
ILE A 192
 None
 1.01A 6mkeB-2btvA:
undetectable
6mkeC-2btvA:
undetectable		 6mkeB-2btvA:
5.76
6mkeC-2btvA:
5.76