SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 HIS A 253
PHE A  24
PHE A  19
ALA A 251
GLY A 250
 ARG  A1283 ( 4.9A)
None
ARG  A1283 (-4.7A)
None
None
 1.37A 1a4lD-2btyA:
undetectable		 1a4lD-2btyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.77A 1hshB-2btyA:
undetectable		 1hshB-2btyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.85A 1p7lD-2btyA:
undetectable		 1p7lD-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.86A 1p7lC-2btyA:
undetectable		 1p7lC-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 GLU A  95
ASP A 124
ILE A 165
GLY A 169
SER A 176
 None
 1.49A 1q8jA-2btyA:
undetectable		 1q8jA-2btyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.86A 1rg9B-2btyA:
undetectable		 1rg9B-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.87A 1rg9A-2btyA:
undetectable		 1rg9A-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.86A 1rg9D-2btyA:
undetectable		 1rg9D-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.86A 1rg9C-2btyA:
undetectable		 1rg9C-2btyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 5 GLY A  29
PRO A  64
ALA A  65
ILE A 102
 NLG  A1284 (-3.0A)
None
None
None
 0.93A 2aofA-2btyA:
undetectable		 2aofA-2btyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 LEU A 199
ILE A 213
ILE A 225
VAL A 252
ILE A 254
 None
 1.04A 2avoA-2btyA:
undetectable		 2avoA-2btyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		3 / 3 LYS A  27
GLY A  63
PRO A  64
 NLG  A1284 (-3.4A)
NLG  A1284 ( 4.2A)
None
 0.84A 2hreB-2btyA:
undetectable		 2hreB-2btyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ALA A 181
GLY A  30
GLY A  62
HIS A  60
ILE A 102
 NLG  A1284 ( 4.4A)
NLG  A1284 (-2.7A)
NLG  A1284 (-4.0A)
None
None
 1.28A 2v7bA-2btyA:
2.7		 2v7bA-2btyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ALA A 181
GLY A  30
GLY A  62
HIS A  60
ILE A 102
 NLG  A1284 ( 4.4A)
NLG  A1284 (-2.7A)
NLG  A1284 (-4.0A)
None
None
 1.27A 2v7bB-2btyA:
3.4		 2v7bB-2btyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 5 PRO A  56
ILE A 157
PRO A 163
TYR A 161
 None
 1.21A 3d9lA-2btyA:
undetectable
3d9lY-2btyA:
undetectable		 3d9lA-2btyA:
19.43
3d9lY-2btyA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.98A 3ebzA-2btyA:
undetectable		 3ebzA-2btyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ASP A 202
VAL A 203
GLY A 232
ILE A 235
VAL A 206
 None
 1.05A 3ekvB-2btyA:
undetectable		 3ekvB-2btyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.99A 3s43A-2btyA:
undetectable		 3s43A-2btyA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.96A 3s45A-2btyA:
undetectable		 3s45A-2btyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.87A 3s53B-2btyA:
undetectable		 3s53B-2btyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 GLU A  95
ASP A 124
ILE A 165
GLY A 169
SER A 176
 None
 1.49A 4djfB-2btyA:
undetectable		 4djfB-2btyA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 LYS A  27
ILE A  26
PHE A  28
GLY A  30
 NLG  A1284 (-3.4A)
None
None
NLG  A1284 (-2.7A)
 0.86A 4hb6A-2btyA:
undetectable		 4hb6A-2btyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 LYS A  27
ILE A  26
PHE A  28
GLY A  30
 NLG  A1284 (-3.4A)
None
None
NLG  A1284 (-2.7A)
 0.84A 4hb8A-2btyA:
undetectable		 4hb8A-2btyA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ILE A 255
ILE A  26
MET A  33
GLY A  30
 None
None
None
NLG  A1284 (-2.7A)
 0.91A 4hdlA-2btyA:
undetectable		 4hdlA-2btyA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		3 / 3 VAL A 129
GLY A 169
LYS A 123
 None
 0.65A 4k50A-2btyA:
undetectable		 4k50A-2btyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		3 / 3 VAL A 129
GLY A 169
LYS A 123
 None
 0.70A 4k50E-2btyA:
undetectable		 4k50E-2btyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		3 / 3 VAL A 129
GLY A 169
LYS A 123
 None
 0.66A 4k50I-2btyA:
undetectable		 4k50I-2btyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.88A 4kttD-2btyA:
undetectable		 4kttD-2btyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.90A 4ndnB-2btyA:
undetectable		 4ndnB-2btyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.85A 4ndnD-2btyA:
undetectable		 4ndnD-2btyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.82A 5e5jA-2btyA:
undetectable		 5e5jA-2btyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.88A 5e5jB-2btyA:
undetectable		 5e5jB-2btyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
 None
 0.86A 5e5kB-2btyA:
undetectable		 5e5kB-2btyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 117
ASP A  45
ILE A  46
ILE A  26
 None
 0.86A 5t8sA-2btyA:
undetectable		 5t8sA-2btyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 5 PHE A  28
THR A 201
ASP A 182
ASN A 178
 None
None
NLG  A1284 (-3.4A)
None
 1.49A 5ybbA-2btyA:
1.0		 5ybbA-2btyA:
22.09