SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 4 GLY A  66
LEU A  70
GLY A  98
ARG A 101
 None
 1.09A 1j7kA-2bugA:
undetectable		 1j7kA-2bugA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 ASP A 118
TYR A  99
LYS A  93
 None
 1.22A 2othA-2bugA:
undetectable		 2othA-2bugA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 LYS A  97
TYR A 100
ARG A 101
 None
 0.95A 4gc9A-2bugA:
undetectable		 4gc9A-2bugA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 CYH A 139
MET A 107
ASN A 106
 None
 0.96A 5qh8A-2bugA:
undetectable		 5qh8A-2bugA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 LYS A 126
PRO A 127
LYS A 133
 None
 1.23A 5y9yA-2bugA:
undetectable		 5y9yA-2bugA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 6 ALA A  81
SER A  69
ALA A 104
SER A 105
 None
 0.81A 6bocA-2bugA:
undetectable
6bocB-2bugA:
undetectable
6bocC-2bugA:
undetectable
6bocD-2bugA:
undetectable		 6bocA-2bugA:
13.59
6bocB-2bugA:
13.59
6bocC-2bugA:
13.59
6bocD-2bugA:
13.59