SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2buj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 ALA A  62
GLU A  65
LEU A  96
LEU A  85
 None
 0.81A 1ereE-2bujA:
undetectable		 1ereE-2bujA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 ALA A  62
GLU A  65
LEU A  96
LEU A  85
 None
 0.79A 1ereF-2bujA:
undetectable		 1ereF-2bujA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.75A 1iepA-2bujA:
23.0		 1iepA-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
 0.85A 1iepB-2bujA:
23.2		 1iepB-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 9 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A  78
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.8A)
 1.05A 1muoA-2bujA:
8.2		 1muoA-2bujA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 ILE A 132
GLY A 222
VAL A 224
SER A 271
MET A 272
 None
 1.31A 1nbhA-2bujA:
undetectable		 1nbhA-2bujA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 ILE A 132
GLY A 222
VAL A 224
SER A 271
MET A 272
 None
 1.31A 1nbhC-2bujA:
undetectable		 1nbhC-2bujA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 ILE A 132
GLY A 222
VAL A 224
SER A 271
MET A 272
 None
 1.31A 1nbhD-2bujA:
undetectable		 1nbhD-2bujA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.72A 1opjA-2bujA:
22.7		 1opjA-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
 0.75A 1opjB-2bujA:
22.9		 1opjB-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 LEU A 221
ILE A 154
GLY A 135
HIS A 140
 None
 0.74A 1sv9A-2bujA:
undetectable		 1sv9A-2bujA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		3 / 3 ASP A  35
TYR A  33
GLU A  93
 None
 0.83A 1vm1A-2bujA:
undetectable		 1vm1A-2bujA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.80A 2hyyA-2bujA:
23.1		 2hyyA-2bujA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.80A 2hyyB-2bujA:
23.2		 2hyyB-2bujA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.84A 2hyyC-2bujA:
23.2		 2hyyC-2bujA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.83A 2hyyD-2bujA:
22.9		 2hyyD-2bujA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		3 / 3 LEU A  52
TYR A  33
GLY A  27
 None
None
STU  A1301 ( 3.8A)
 0.60A 2ocuA-2bujA:
undetectable		 2ocuA-2bujA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 5 LEU A 221
ILE A 154
GLY A 135
HIS A 140
 None
 0.71A 2otfA-2bujA:
undetectable		 2otfA-2bujA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  34
ALA A  47
LEU A  78
LEU A  98
GLY A 104
ASP A 166
 STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
None
 0.71A 2wgjA-2bujA:
23.3		 2wgjA-2bujA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 9 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.72A 2xp2A-2bujA:
23.9		 2xp2A-2bujA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 8 LEU A  26
ALA A  47
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.77A 2yfxA-2bujA:
23.7		 2yfxA-2bujA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 LEU A 221
ILE A 283
HIS A 140
ARG A 280
 None
 0.97A 3b9lA-2bujA:
undetectable		 3b9lA-2bujA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  27
ALA A  47
LYS A  49
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.71A 3c7qA-2bujA:
22.1		 3c7qA-2bujA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 10 LEU A  26
VAL A  34
LYS A  49
PHE A 100
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
None
 0.74A 3cs9A-2bujA:
23.0		 3cs9A-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  65
GLY A 104
HIS A 146
LEU A 155
 STU  A1301 (-3.6A)
None
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
 0.43A 3cs9A-2bujA:
23.0		 3cs9A-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 6 LEU A  26
VAL A  34
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.8A)
None
 0.84A 3cs9D-2bujA:
22.3		 3cs9D-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 6 LEU A  26
VAL A  34
LYS A  49
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.66A 3cs9D-2bujA:
22.3		 3cs9D-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  65
ILE A 139
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
 0.79A 3hegA-2bujA:
22.0		 3hegA-2bujA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.78A 3k5vA-2bujA:
22.9		 3k5vA-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.77A 3k5vB-2bujA:
22.7		 3k5vB-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 ALA A  47
LYS A  49
GLU A  65
LEU A  96
 STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
 0.33A 3lfaA-2bujA:
22.2		 3lfaA-2bujA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.73A 3ms9A-2bujA:
22.7		 3ms9A-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.72A 3ms9B-2bujA:
22.8		 3ms9B-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.74A 3mssA-2bujA:
22.9		 3mssA-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.48A 3mssB-2bujA:
22.7		 3mssB-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.76A 3mssB-2bujA:
22.7		 3mssB-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.76A 3mssC-2bujA:
22.8		 3mssC-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.76A 3mssD-2bujA:
22.7		 3mssD-2bujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 11 ASP A 148
ASN A 153
LEU A 149
VAL A 224
PHE A 239
 None
 1.29A 3n23C-2bujA:
undetectable		 3n23C-2bujA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 LEU A 155
PHE A 101
ILE A 139
ALA A 138
GLY A 131
 STU  A1301 ( 4.8A)
None
None
None
None
 1.07A 3nxuA-2bujA:
undetectable		 3nxuA-2bujA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.65A 3pyyA-2bujA:
23.0		 3pyyA-2bujA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.78A 3pyyA-2bujA:
23.0		 3pyyA-2bujA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
ALA A  47
LYS A  49
GLU A  65
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.76A 3ue4A-2bujA:
25.0		 3ue4A-2bujA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.76A 3ue4B-2bujA:
25.3		 3ue4B-2bujA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
LEU A  96
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.60A 3ug2A-2bujA:
24.5		 3ug2A-2bujA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 ALA A  47
LEU A  78
LEU A  98
GLY A 104
LEU A 155
 STU  A1301 (-3.6A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.53A 3zbfA-2bujA:
25.2		 3zbfA-2bujA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 ALA A  47
LEU A  78
LEU A  98
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.8A)
None
 0.57A 3zbfA-2bujA:
25.2		 3zbfA-2bujA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
PHE A 100
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.84A 4ag8A-2bujA:
22.6		 4ag8A-2bujA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 9 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.75A 4anqA-2bujA:
23.9		 4anqA-2bujA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
PHE A 100
GLY A 104
HIS A 146
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
 0.75A 4asdA-2bujA:
22.6		 4asdA-2bujA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  65
LEU A  78
HIS A 146
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
None
STU  A1301 ( 4.8A)
None
 0.92A 4c8bA-2bujA:
24.2		 4c8bA-2bujA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
GLU A  65
ILE A  77
LEU A  78
HIS A 146
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
None
None
STU  A1301 ( 4.8A)
None
 0.98A 4c8bB-2bujA:
24.2		 4c8bB-2bujA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 5 LEU A  97
ASP A  35
ARG A  50
TRP A  95
 None
 1.42A 4cpzA-2bujA:
undetectable		 4cpzA-2bujA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  96
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.88A 4i22A-2bujA:
22.0		 4i22A-2bujA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 11 VAL A  34
ALA A  47
LYS A  49
LEU A  98
LEU A 155
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.8A)
 0.63A 4iaaA-2bujA:
25.8		 4iaaA-2bujA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.72A 4mkcA-2bujA:
23.9		 4mkcA-2bujA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 5 LEU A  97
ASP A  35
ARG A  50
TRP A  95
 None
 1.47A 4mwrA-2bujA:
undetectable		 4mwrA-2bujA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 6 VAL A  34
ALA A  47
LEU A  78
THR A 105
LEU A 155
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
None
STU  A1301 ( 4.8A)
 0.86A 4o0uA-2bujA:
8.7		 4o0uA-2bujA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 LEU A  26
VAL A  34
LYS A  49
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.86A 4qrcA-2bujA:
23.0		 4qrcA-2bujA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 VAL A  34
LYS A  49
HIS A 146
LEU A 155
 STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
 0.84A 4qrcA-2bujA:
23.0		 4qrcA-2bujA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		9 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
PHE A 100
GLY A 104
ASN A 153
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
None
 0.64A 4twpA-2bujA:
24.9		 4twpA-2bujA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		9 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
PHE A 100
GLY A 104
ASN A 153
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
None
 0.70A 4twpB-2bujA:
25.1		 4twpB-2bujA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
PHE A 100
GLY A 104
ASN A 153
LEU A 155
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
 0.71A 4wa9B-2bujA:
24.2		 4wa9B-2bujA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.75A 4wkqA-2bujA:
25.0		 4wkqA-2bujA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		3 / 4 ARG A 134
GLY A 135
GLU A 137
 None
 0.60A 4z2dB-2bujA:
undetectable
4z2dC-2bujA:
undetectable		 4z2dB-2bujA:
20.88
4z2dC-2bujA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 8 LEU A  26
GLY A  27
VAL A  34
ALA A  47
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
 0.67A 4zauA-2bujA:
24.4		 4zauA-2bujA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 9 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.69A 5aaaA-2bujA:
23.9		 5aaaA-2bujA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 10 LEU A  26
VAL A  34
ALA A  47
LYS A  49
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.79A 5aabA-2bujA:
23.9		 5aabA-2bujA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 10 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.79A 5aacA-2bujA:
23.7		 5aacA-2bujA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 10 LEU A  26
VAL A  34
ALA A  47
LYS A  49
LEU A  98
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.8A)
None
 0.84A 5aacA-2bujA:
23.7		 5aacA-2bujA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 12 LEU A  26
ALA A  47
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.82A 5ajqA-2bujA:
24.7		 5ajqA-2bujA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 10 ALA A  47
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.66A 5ajqB-2bujA:
25.3		 5ajqB-2bujA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 6 ILE A  15
VAL A  37
VAL A  81
HIS A  44
 None
 0.88A 5eclD-2bujA:
undetectable		 5eclD-2bujA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 12 LEU A  26
VAL A  34
ALA A  47
LEU A  78
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 1.05A 5h2uA-2bujA:
22.3		 5h2uA-2bujA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 5 CYH A 133
HIS A 282
LEU A 286
HIS A 140
 None
 1.47A 5hrqA-2bujA:
undetectable
5hrqB-2bujA:
undetectable
5hrqF-2bujA:
undetectable		 5hrqA-2bujA:
8.52
5hrqB-2bujA:
6.02
5hrqF-2bujA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 6 HIS A 140
CYH A 133
HIS A 282
LEU A 286
 None
 1.42A 5hrqD-2bujA:
undetectable
5hrqG-2bujA:
undetectable
5hrqH-2bujA:
undetectable		 5hrqD-2bujA:
6.02
5hrqG-2bujA:
8.52
5hrqH-2bujA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 6 HIS A 140
CYH A 133
HIS A 282
LEU A 286
 None
 1.44A 5hrqH-2bujA:
undetectable
5hrqK-2bujA:
undetectable
5hrqL-2bujA:
undetectable		 5hrqH-2bujA:
6.02
5hrqK-2bujA:
8.52
5hrqL-2bujA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 6 VAL A 249
LEU A 221
SER A 220
ILE A 132
 None
 0.96A 5jw1A-2bujA:
undetectable		 5jw1A-2bujA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
GLU A  65
LEU A  98
GLY A 104
 STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
 0.76A 5mafA-2bujA:
26.9		 5mafA-2bujA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 10 LEU A  26
VAL A  34
LYS A  49
GLU A  65
PHE A 100
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
 0.66A 5mo4A-2bujA:
19.7		 5mo4A-2bujA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		5 / 12 GLU A  93
ILE A  51
GLU A  55
ALA A  62
TYR A  83
 None
 1.02A 5n5dB-2bujA:
undetectable		 5n5dB-2bujA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 ALA A  47
GLU A  65
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
None
STU  A1301 ( 4.8A)
None
 0.59A 5owrA-2bujA:
23.9		 5owrA-2bujA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  36
ALA A  47
GLU A  65
PHE A 100
GLY A 104
ASN A 108
LEU A 155
 None
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
 0.82A 5te0A-2bujA:
30.3		 5te0A-2bujA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 12 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
 0.81A 5vcvA-2bujA:
25.3		 5vcvA-2bujA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
 0.81A 5vcyA-2bujA:
25.2		 5vcyA-2bujA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		4 / 8 VAL A 218
ASP A 217
HIS A 282
GLY A 135
 None
 0.88A 5w3jB-2bujA:
undetectable		 5w3jB-2bujA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.73A 5y7zA-2bujA:
31.0		 5y7zA-2bujA:
11.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.73A 5y7zA-2bujA:
31.0		 5y7zA-2bujA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.89A 5y7zB-2bujA:
30.9		 5y7zB-2bujA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.62A 5y80A-2bujA:
29.7		 5y80A-2bujA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		3 / 3 ALA A  82
VAL A  37
TYR A  46
 None
 0.70A 5zmqH-2bujA:
1.6		 5zmqH-2bujA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		3 / 3 LYS A  49
LEU A 155
ASP A 166
 STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.90A 5zv2A-2bujA:
22.7		 5zv2A-2bujA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		6 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
 0.68A 5zv2B-2bujA:
22.7		 5zv2B-2bujA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.84A 6hd6A-2bujA:
22.8		 6hd6A-2bujA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
GLU A  65
PHE A 100
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
None
 0.74A 6hd6B-2bujA:
22.7		 6hd6B-2bujA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
PHE A 100
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.8A)
 0.64A 6hd6B-2bujA:
22.7		 6hd6B-2bujA:
12.89