SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 6 ILE A 335
ASN A 333
SER A 313
ASN A 310
 None
 1.26A 1h7xA-2bv5A:
undetectable		 1h7xA-2bv5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 6 ILE A 335
ASN A 333
SER A 313
ASN A 310
 None
 1.26A 1h7xB-2bv5A:
undetectable		 1h7xB-2bv5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 6 ILE A 335
ASN A 333
SER A 313
ASN A 310
 None
 1.25A 1h7xC-2bv5A:
undetectable		 1h7xC-2bv5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 6 ILE A 335
ASN A 333
SER A 313
ASN A 310
 None
 1.25A 1h7xD-2bv5A:
undetectable		 1h7xD-2bv5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		5 / 12 LEU A 317
ILE A 346
THR A 348
ILE A 400
LEU A 418
 None
 0.99A 1tw4A-2bv5A:
0.6		 1tw4A-2bv5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		6 / 12 LEU A 317
ILE A 346
THR A 348
ASP A 358
ILE A 400
LEU A 418
 None
 1.10A 2jn3A-2bv5A:
undetectable		 2jn3A-2bv5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 6 ASP A 396
VAL A 398
PRO A 320
TRP A 364
 None
 1.26A 2q6oB-2bv5A:
undetectable		 2q6oB-2bv5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		3 / 3 ASN A 302
ASN A 331
ARG A 511
 None
 0.82A 2rlcA-2bv5A:
undetectable		 2rlcA-2bv5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		5 / 8 HIS A 471
LEU A 418
ILE A 416
LEU A 427
THR A 368
 SCY  A 472 ( 4.2A)
None
None
None
None
 1.39A 2xfhA-2bv5A:
undetectable		 2xfhA-2bv5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		3 / 3 ASP A 358
ARG A 361
ARG A 300
 None
 1.03A 3k37A-2bv5A:
undetectable		 3k37A-2bv5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		6 / 12 GLY A 475
VAL A 470
GLY A 513
MET A 514
LEU A 507
ILE A 335
 SCY  A 472 ( 3.6A)
None
None
None
None
None
 1.29A 3ku1A-2bv5A:
undetectable		 3ku1A-2bv5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		6 / 12 GLY A 475
VAL A 470
GLY A 513
MET A 514
LEU A 507
ILE A 335
 SCY  A 472 ( 3.6A)
None
None
None
None
None
 1.27A 3ku1C-2bv5A:
undetectable		 3ku1C-2bv5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		5 / 12 VAL A 363
ILE A 469
ILE A 370
ARG A 412
LEU A 427
 None
 0.82A 4iv0A-2bv5A:
undetectable		 4iv0A-2bv5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 7 MET A 362
ARG A 511
VAL A 470
MET A 373
 None
 1.47A 4klaA-2bv5A:
0.0		 4klaA-2bv5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		5 / 12 VAL A 363
ILE A 469
ILE A 370
ARG A 412
LEU A 427
 None
 0.82A 4mwzB-2bv5A:
undetectable		 4mwzB-2bv5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 7 VAL A 454
PHE A 432
VAL A 372
ILE A 468
 None
 0.74A 5bmvC-2bv5A:
undetectable		 5bmvC-2bv5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens) 		4 / 8 ARG A 425
THR A 368
PRO A 369
ILE A 346
 None
 0.91A 6a4iA-2bv5A:
undetectable		 6a4iA-2bv5A:
20.14