SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 12 ILE A 107
GLY A 105
LEU A 272
LEU A 259
TYR A 255
 None
 1.12A 1fm6X-2bvmA:
undetectable		 1fm6X-2bvmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 8 TYR A 407
ILE A 403
ILE A 271
SER A 251
 None
 0.91A 1mrjA-2bvmA:
undetectable		 1mrjA-2bvmA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2bvm TOXIN B
(Clostridioides
difficile) 		3 / 3 ILE A 138
LEU A 141
VAL A 145
 None
 0.49A 1mz9B-2bvmA:
undetectable		 1mz9B-2bvmA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 8 LEU A  79
GLU A  82
TYR A  34
ILE A  52
 None
 0.99A 1qvtA-2bvmA:
undetectable		 1qvtA-2bvmA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 5 ASP A 203
THR A 140
LEU A 141
LEU A 137
 None
 1.12A 1u18B-2bvmA:
undetectable		 1u18B-2bvmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 12 SER A 393
SER A 396
ILE A 399
ASN A 384
LEU A 387
 None
None
None
GLC  A1544 (-3.8A)
None
 1.01A 2nnhA-2bvmA:
undetectable		 2nnhA-2bvmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 11 SER A 413
ILE A 435
PHE A 446
THR A 464
LEU A 468
 None
 1.28A 2v0mD-2bvmA:
undetectable		 2v0mD-2bvmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 6 LEU A   9
ALA A  26
LEU A  55
THR A  56
 None
 0.98A 3rozA-2bvmA:
1.1		 3rozA-2bvmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 11 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
GLC  A1544 (-3.2A)
None
 1.04A 3spkA-2bvmA:
undetectable		 3spkA-2bvmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 7 ASN A 264
ALA A 267
GLY A 470
ILE A 466
 None
None
GLC  A1544 (-3.2A)
None
 0.84A 3spkB-2bvmA:
undetectable		 3spkB-2bvmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 12 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
GLC  A1544 (-3.2A)
None
 0.95A 3spkB-2bvmA:
undetectable		 3spkB-2bvmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 10 THR A  56
LEU A  31
VAL A   4
VAL A  80
PHE A 484
 None
 1.37A 3tbgC-2bvmA:
undetectable		 3tbgC-2bvmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 11 GLN A 402
MET A 447
PHE A 446
ASN A 490
ASN A 412
 None
 1.27A 4a99D-2bvmA:
0.2		 4a99D-2bvmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 7 TYR A 284
LEU A 277
ASN A 384
TYR A 478
 None
None
GLC  A1544 (-3.8A)
None
 1.40A 4f8yC-2bvmA:
undetectable
4f8yD-2bvmA:
undetectable		 4f8yC-2bvmA:
15.94
4f8yD-2bvmA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2bvm TOXIN B
(Clostridioides
difficile) 		3 / 3 GLU A  33
ASP A  29
ASP A  51
 None
 0.74A 4gc9A-2bvmA:
undetectable		 4gc9A-2bvmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2bvm TOXIN B
(Clostridioides
difficile) 		3 / 3 ASP A 109
ASN A 116
SER A 228
 None
 0.77A 4obwA-2bvmA:
undetectable		 4obwA-2bvmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2bvm TOXIN B
(Clostridioides
difficile) 		3 / 3 LEU A 265
ASP A 270
ILE A 107
 UDP  A1543 (-3.9A)
GLC  A1544 (-2.9A)
None
 0.70A 4xi3D-2bvmA:
undetectable		 4xi3D-2bvmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 7 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.17A 4yv5A-2bvmA:
2.5		 4yv5A-2bvmA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 7 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.22A 4yv5B-2bvmA:
2.2		 4yv5B-2bvmA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 5 GLU A  82
THR A  81
THR A  56
LEU A   9
 None
 1.23A 5hm8B-2bvmA:
undetectable		 5hm8B-2bvmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 5 GLU A  82
THR A  81
THR A  56
LEU A   9
 None
 1.24A 5hm8C-2bvmA:
undetectable		 5hm8C-2bvmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 5 GLU A  82
THR A  81
THR A  56
LEU A   9
 None
 1.23A 5hm8E-2bvmA:
undetectable		 5hm8E-2bvmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 5 GLU A  82
THR A  81
THR A  56
LEU A   9
 None
 1.23A 5hm8F-2bvmA:
undetectable		 5hm8F-2bvmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bvm TOXIN B
(Clostridioides
difficile) 		4 / 5 GLU A  82
THR A  81
THR A  56
LEU A   9
 None
 1.23A 5hm8H-2bvmA:
undetectable		 5hm8H-2bvmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 9 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
GLC  A1544 (-3.2A)
None
 1.25A 5kr2A-2bvmA:
undetectable		 5kr2A-2bvmA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 2bvm TOXIN B
(Clostridioides
difficile) 		5 / 9 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
GLC  A1544 (-3.2A)
None
 0.96A 5kr2C-2bvmA:
undetectable		 5kr2C-2bvmA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2bvm TOXIN B
(Clostridioides
difficile) 		3 / 3 TYR A  24
ALA A  71
LEU A   9
 None
 0.45A 6d9kF-2bvmA:
undetectable		 6d9kF-2bvmA:
20.17