SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 6 VAL A  27
GLY A  26
ALA A 317
LEU A  33
 None
 0.64A 1e7bB-2bvtA:
undetectable		 1e7bB-2bvtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 6 HIS A 376
ILE A 377
ALA A 431
VAL A 447
 None
 0.92A 1hk1A-2bvtA:
undetectable		 1hk1A-2bvtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		3 / 3 THR A  40
GLU A 320
ASP A 246
 None
 0.81A 1nt2A-2bvtA:
undetectable		 1nt2A-2bvtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 LEU A  72
VAL A 114
ARG A  87
THR A  71
 None
 1.36A 1nw3A-2bvtA:
undetectable		 1nw3A-2bvtA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 8 THR A 200
LEU A 204
THR A  71
VAL A 114
 None
 0.94A 1o76B-2bvtA:
undetectable		 1o76B-2bvtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 12 GLU A 175
ASN A 176
ILE A 267
ASP A 263
GLY A 221
 CAC  A 600 (-2.6A)
None
None
None
None
 1.29A 1q8jA-2bvtA:
7.5		 1q8jA-2bvtA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 10 ASP A 246
TYR A 193
THR A 281
GLY A 244
ARG A 171
 None
 1.46A 1rmtA-2bvtA:
2.3		 1rmtA-2bvtA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 11 ALA A 317
VAL A 277
LEU A 353
PRO A  64
VAL A 358
 None
 1.13A 1rv7A-2bvtA:
undetectable
1rv7B-2bvtA:
undetectable		 1rv7A-2bvtA:
12.64
1rv7B-2bvtA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 12 MET A 319
ARG A 315
LEU A 304
ILE A 307
PHE A 354
 None
 1.04A 1y0xX-2bvtA:
undetectable		 1y0xX-2bvtA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 7 SER A  54
PHE A  63
GLY A 106
ILE A 168
 None
 0.86A 2bdmA-2bvtA:
undetectable		 2bdmA-2bvtA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 ILE A   6
LEU A  21
ASP A  10
ALA A 368
 None
 1.01A 2opxA-2bvtA:
undetectable		 2opxA-2bvtA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 7 ILE A 168
SER A 158
PHE A  94
ILE A  74
 None
 0.82A 2q6hA-2bvtA:
undetectable		 2q6hA-2bvtA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 7 ILE A 168
SER A 158
PHE A  94
ILE A  74
 None
 0.81A 2qb4A-2bvtA:
undetectable		 2qb4A-2bvtA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		3 / 3 MET A 266
MET A 319
PHE A 223
 None
 1.17A 3gn8A-2bvtA:
undetectable		 3gn8A-2bvtA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 8 ALA A 279
ARG A  28
LEU A 264
ALA A 271
 None
 0.89A 3hrdA-2bvtA:
undetectable
3hrdB-2bvtA:
undetectable		 3hrdA-2bvtA:
21.77
3hrdB-2bvtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		3 / 4 SER A 253
GLY A 222
GLU A 175
 None
None
CAC  A 600 (-2.6A)
 0.68A 3raeA-2bvtA:
undetectable
3raeC-2bvtA:
undetectable		 3raeA-2bvtA:
23.50
3raeC-2bvtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 12 LEU A 427
THR A 392
THR A 391
LEU A 421
ILE A 377
 None
 1.25A 3sp9A-2bvtA:
undetectable		 3sp9A-2bvtA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 7 THR A 321
GLY A 284
GLY A 290
THR A 291
 None
 0.77A 3tajA-2bvtA:
undetectable		 3tajA-2bvtA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 ILE A  32
ARG A 315
ASP A  25
VAL A  66
 None
 1.09A 4nkxC-2bvtA:
undetectable		 4nkxC-2bvtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 ILE A  32
ARG A 315
ASP A  25
VAL A  66
 None
 1.13A 4nkxD-2bvtA:
undetectable		 4nkxD-2bvtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		3 / 3 ASP A 424
TYR A 423
TRP A 428
 None
 0.97A 4p7nA-2bvtA:
12.9		 4p7nA-2bvtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 12 LEU A  21
ALA A 279
LEU A 243
GLY A 275
ASP A 272
 None
 1.22A 4qckA-2bvtA:
undetectable		 4qckA-2bvtA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 12 ILE A   8
ASP A 241
TYR A 215
ALA A 152
ALA A 155
 None
 1.45A 4u14A-2bvtA:
undetectable		 4u14A-2bvtA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 GLY A 383
ALA A 384
GLY A 191
PRO A 190
 None
 0.92A 4u9uA-2bvtA:
undetectable		 4u9uA-2bvtA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 GLY A 383
ALA A 384
GLY A 191
PRO A 190
 None
 0.93A 4u9uB-2bvtA:
undetectable		 4u9uB-2bvtA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 10 ALA A 112
ILE A 151
PRO A 172
LEU A 148
LEU A 204
 None
 1.04A 4xj7A-2bvtA:
undetectable
4xj7B-2bvtA:
undetectable		 4xj7A-2bvtA:
22.35
4xj7B-2bvtA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 10 LEU A 148
LEU A 204
ALA A 112
ILE A 151
PRO A 172
 None
 1.06A 4xj7C-2bvtA:
undetectable
4xj7D-2bvtA:
undetectable		 4xj7C-2bvtA:
22.35
4xj7D-2bvtA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 11 ALA A 305
ASP A 263
GLY A 252
PHE A 256
GLY A 259
 None
 1.24A 4xp4A-2bvtA:
undetectable		 4xp4A-2bvtA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 11 THR A  49
GLY A  43
ASP A 326
PHE A 325
GLU A  78
 None
None
None
BMA  A 501 (-3.9A)
BMA  A 500 ( 3.5A)
 1.36A 4xt7A-2bvtA:
undetectable		 4xt7A-2bvtA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		4 / 5 ASP A 246
TRP A 217
GLY A 220
ASN A 176
 None
 1.49A 5x7pB-2bvtA:
2.2		 5x7pB-2bvtA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		5 / 9 TYR A 197
TYR A 193
ALA A 177
THR A 281
LEU A 243
 None
 1.41A 6ay6A-2bvtA:
undetectable		 6ay6A-2bvtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		3 / 3 PHE A 239
ARG A 396
ALA A 371
 None
 0.89A 6ecfB-2bvtA:
2.8		 6ecfB-2bvtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2bvt BETA-1,4-MANNANASE
(Cellulomonas
fimi) 		3 / 3 ARG A 364
PHE A 362
GLY A 360
 None
 0.73A 6fgdA-2bvtA:
undetectable		 6fgdA-2bvtA:
22.63