SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bw2 BYPASS OF FORESPORE
C
(Bacillus
subtilis) 		5 / 12 ASN A  72
ASP A  21
ILE A 132
GLY A  76
ILE A  75
 None
 1.35A 1q8jA-2bw2A:
undetectable		 1q8jA-2bw2A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2bw2 BYPASS OF FORESPORE
C
(Bacillus
subtilis) 		4 / 8 PHE A  39
GLU A  31
PHE A  58
LEU A  15
 None
 0.94A 3i45A-2bw2A:
undetectable		 3i45A-2bw2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2bw2 BYPASS OF FORESPORE
C
(Bacillus
subtilis) 		3 / 3 PHE A  58
VAL A  13
GLU A  31
 None
 0.65A 4fvqA-2bw2A:
undetectable		 4fvqA-2bw2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2bw2 BYPASS OF FORESPORE
C
(Bacillus
subtilis) 		4 / 5 LEU A 116
GLY A  76
ILE A 103
LYS A 136
 None
 1.17A 4ma8C-2bw2A:
undetectable		 4ma8C-2bw2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2bw2 BYPASS OF FORESPORE
C
(Bacillus
subtilis) 		5 / 12 ASN A  72
GLY A  76
GLY A 119
GLU A  91
ILE A  97
 None
 1.05A 6ectA-2bw2A:
undetectable		 6ectA-2bw2A:
17.24