SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2bw3 TRANSPOSASE
(Musca
domestica) 		3 / 3 TRP A 543
TYR A 436
LEU A 562
 None
 0.95A 1kxhA-2bw3A:
undetectable		 1kxhA-2bw3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 12 LEU A 557
ALA A 558
PRO A 437
LEU A 440
PHE A 434
 None
 1.23A 1og5A-2bw3A:
undetectable		 1og5A-2bw3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bw3 TRANSPOSASE
(Musca
domestica) 		3 / 3 GLU A 238
GLU A 171
LEU A 196
 None
 0.74A 1v8bB-2bw3A:
undetectable		 1v8bB-2bw3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 12 THR A 574
ILE A 582
VAL A 594
ILE A 208
LEU A 597
 None
 1.14A 1z9hD-2bw3A:
undetectable		 1z9hD-2bw3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 6 LEU A 192
VAL A 194
ILE A 179
ILE A 224
 None
 0.79A 2piwA-2bw3A:
undetectable		 2piwA-2bw3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 12 LEU A 141
LEU A 140
MET A 120
LEU A 147
THR A 146
 None
 1.30A 2q7kA-2bw3A:
undetectable		 2q7kA-2bw3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 12 LEU B 141
LEU B 140
MET B 120
LEU B 147
THR B 146
 None
 1.21A 2q7kA-2bw3B:
undetectable		 2q7kA-2bw3B:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2bw3 TRANSPOSASE
(Musca
domestica) 		3 / 3 PHE A 235
SER A 602
LEU A 598
 None
 0.52A 2w1bA-2bw3A:
undetectable		 2w1bA-2bw3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 6 SER A 309
VAL A 361
TYR A 323
ASP A 331
 None
 1.38A 2x45A-2bw3A:
undetectable		 2x45A-2bw3A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2bw3 TRANSPOSASE
TRANSPOSASE
(Musca
domestica;
Musca
domestica) 		3 / 3 ASP B 133
THR B  85
GLU A 130
 None
 0.83A 2zifB-2bw3B:
undetectable		 2zifB-2bw3B:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 5 VAL A 137
VAL A 135
PHE B 123
ARG B  81
 None
 1.15A 3bjwB-2bw3A:
undetectable		 3bjwB-2bw3A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 7 TYR A 551
LEU A 562
PHE A 434
VAL A 447
 None
 1.05A 3jwqC-2bw3A:
undetectable		 3jwqC-2bw3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 11 LEU A 600
SER A 602
PHE A 603
PHE A 232
SER A 571
 None
 1.32A 3ko0C-2bw3A:
undetectable
3ko0D-2bw3A:
undetectable
3ko0E-2bw3A:
0.4
3ko0F-2bw3A:
undetectable		 3ko0C-2bw3A:
11.28
3ko0D-2bw3A:
11.28
3ko0E-2bw3A:
11.28
3ko0F-2bw3A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 5 VAL A 594
PHE A 235
ILE A 231
PHE A 232
 None
 1.05A 3owxB-2bw3A:
undetectable		 3owxB-2bw3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2bw3 TRANSPOSASE
TRANSPOSASE
(Musca
domestica;
Musca
domestica) 		5 / 12 VAL B 127
ILE A 121
ILE B 121
VAL A 137
LEU A 140
 None
 1.28A 3w67D-2bw3B:
undetectable		 3w67D-2bw3B:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2bw3 TRANSPOSASE
TRANSPOSASE
(Musca
domestica;
Musca
domestica) 		6 / 12 VAL B 127
ILE A 121
ILE B 121
VAL A 137
LEU A 140
VAL B  86
 None
 1.48A 3w68D-2bw3B:
undetectable		 3w68D-2bw3B:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 9 ILE A 406
PHE A 278
LEU A 409
LEU A 364
PHE A 367
 None
 1.17A 4qopA-2bw3A:
undetectable		 4qopA-2bw3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 9 ILE A 406
PHE A 278
LEU A 409
LEU A 364
PHE A 367
 None
 1.19A 4qopB-2bw3A:
undetectable		 4qopB-2bw3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 12 ILE A 349
ALA A 290
TYR A 297
LEU A 340
LEU A 307
 None
 1.35A 4qztC-2bw3A:
undetectable		 4qztC-2bw3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bw3 TRANSPOSASE
(Musca
domestica) 		5 / 10 GLY B 128
VAL B 127
GLU B 130
ASP B 133
ILE A 125
 None
 1.01A 5i3cB-2bw3B:
undetectable		 5i3cB-2bw3B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 8 THR A  85
CYH A  90
TYR B 131
LEU B 140
 None
 1.41A 5kxiA-2bw3A:
2.6
5kxiB-2bw3A:
3.0		 5kxiA-2bw3A:
22.04
5kxiB-2bw3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 8 THR A  85
CYH A  90
TYR B 131
LEU B 140
 None
 1.37A 5kxiD-2bw3A:
undetectable
5kxiE-2bw3A:
3.2		 5kxiD-2bw3A:
22.04
5kxiE-2bw3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2bw3 TRANSPOSASE
(Musca
domestica) 		3 / 3 TYR A 527
SER A 555
TRP A 543
 None
 1.06A 5n8jA-2bw3A:
undetectable		 5n8jA-2bw3A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2bw3 TRANSPOSASE
(Musca
domestica) 		3 / 3 TYR A 527
SER A 555
TRP A 543
 None
 1.04A 5n8jD-2bw3A:
undetectable		 5n8jD-2bw3A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2bw3 TRANSPOSASE
(Musca
domestica) 		4 / 8 GLU A 314
GLN A 375
LEU A 374
THR A 376
 None
 0.87A 5sxtB-2bw3A:
1.7		 5sxtB-2bw3A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2bw3 TRANSPOSASE
TRANSPOSASE
(Musca
domestica;
Musca
domestica) 		5 / 12 SER B 148
VAL B 151
ARG A 107
VAL A 102
ASP A 105
 None
 1.41A 6bxlB-2bw3B:
undetectable		 6bxlB-2bw3B:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2bw3 TRANSPOSASE
TRANSPOSASE
(Musca
domestica;
Musca
domestica) 		5 / 10 LEU A 141
LEU A 147
ILE B 118
SER B 110
GLY B 114
 None
 1.26A 6dm0B-2bw3A:
2.5
6dm0C-2bw3A:
undetectable		 6dm0B-2bw3A:
8.44
6dm0C-2bw3A:
8.44