SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 TYR A 285
GLY A 104
ASP A 109
SER A 102
 None
 0.93A 1eswA-2bwgA:
6.4		 1eswA-2bwgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 11 ASP A 129
ASN A 158
GLY A 181
CYH A 186
THR A 188
 None
5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
 1.11A 1jr1A-2bwgA:
39.2		 1jr1A-2bwgA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ASN A 158
GLY A 181
THR A 188
GLY A 290
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.1A)
 0.84A 1jr1B-2bwgA:
39.0		 1jr1B-2bwgA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.93A 1v54N-2bwgA:
undetectable
1v54W-2bwgA:
undetectable		 1v54N-2bwgA:
21.02
1v54W-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.89A 1v55A-2bwgA:
undetectable
1v55J-2bwgA:
undetectable		 1v55A-2bwgA:
21.02
1v55J-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 5 ASP A 237
GLY A 211
VAL A 202
ILE A 216
 None
 0.97A 2aoiA-2bwgA:
undetectable		 2aoiA-2bwgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 156
ILE A 126
GLY A 104
ALA A 100
 None
 1.02A 2b60B-2bwgA:
undetectable		 2b60B-2bwgA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 SER A  22
LEU A  17
LEU A 312
LEU A 324
 None
 0.88A 2bfpC-2bwgA:
undetectable		 2bfpC-2bwgA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.96A 2dyrN-2bwgA:
undetectable
2dyrW-2bwgA:
undetectable		 2dyrN-2bwgA:
21.02
2dyrW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 VAL A 180
GLY A 181
GLY A 183
THR A 188
ALA A 287
 None
K  A1339 (-4.8A)
5GP  A1340 ( 3.2A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.9A)
 1.04A 2egvA-2bwgA:
undetectable		 2egvA-2bwgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 VAL A 180
GLY A 181
GLY A 183
THR A 188
ALA A 287
 None
K  A1339 (-4.8A)
5GP  A1340 ( 3.2A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.9A)
 1.08A 2egvB-2bwgA:
undetectable		 2egvB-2bwgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.92A 2einN-2bwgA:
0.0
2einW-2bwgA:
undetectable		 2einN-2bwgA:
21.02
2einW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.37A 2nsiA-2bwgA:
undetectable
2nsiB-2bwgA:
undetectable		 2nsiA-2bwgA:
20.94
2nsiB-2bwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.41A 2nsiA-2bwgA:
undetectable
2nsiB-2bwgA:
undetectable		 2nsiA-2bwgA:
20.94
2nsiB-2bwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.43A 2nsiC-2bwgA:
undetectable
2nsiD-2bwgA:
undetectable		 2nsiC-2bwgA:
20.94
2nsiD-2bwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.42A 2nsiC-2bwgA:
undetectable
2nsiD-2bwgA:
undetectable		 2nsiC-2bwgA:
20.94
2nsiD-2bwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.92A 3ablA-2bwgA:
0.0
3ablJ-2bwgA:
undetectable		 3ablA-2bwgA:
21.02
3ablJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.87A 3ag1N-2bwgA:
undetectable
3ag1W-2bwgA:
undetectable		 3ag1N-2bwgA:
21.02
3ag1W-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.94A 3ag3A-2bwgA:
undetectable
3ag3J-2bwgA:
undetectable		 3ag3A-2bwgA:
21.02
3ag3J-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.42A 3e7gA-2bwgA:
undetectable
3e7gB-2bwgA:
undetectable		 3e7gA-2bwgA:
21.11
3e7gB-2bwgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.39A 3e7gA-2bwgA:
undetectable
3e7gB-2bwgA:
undetectable		 3e7gA-2bwgA:
21.11
3e7gB-2bwgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.39A 3e7gC-2bwgA:
undetectable
3e7gD-2bwgA:
undetectable		 3e7gC-2bwgA:
21.11
3e7gD-2bwgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.44A 3e7gC-2bwgA:
undetectable
3e7gD-2bwgA:
undetectable		 3e7gC-2bwgA:
21.11
3e7gD-2bwgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 8 GLY A 172
ALA A 173
ASP A 174
LEU A 144
VAL A 130
 None
 1.33A 3em6A-2bwgA:
undetectable		 3em6A-2bwgA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 GLY A 183
CYH A 251
PHE A 266
GLY A 268
 5GP  A1340 ( 3.2A)
None
None
5GP  A1340 (-3.3A)
 0.89A 3ko0M-2bwgA:
undetectable
3ko0P-2bwgA:
undetectable		 3ko0M-2bwgA:
13.22
3ko0P-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 GLY A 183
CYH A 251
PHE A 266
GLY A 268
 5GP  A1340 ( 3.2A)
None
None
5GP  A1340 (-3.3A)
 0.89A 3ko0O-2bwgA:
undetectable
3ko0Q-2bwgA:
undetectable		 3ko0O-2bwgA:
13.22
3ko0Q-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 266
GLY A 268
GLY A 183
CYH A 251
 None
5GP  A1340 (-3.3A)
5GP  A1340 ( 3.2A)
None
 0.84A 3ko0M-2bwgA:
undetectable
3ko0P-2bwgA:
undetectable		 3ko0M-2bwgA:
13.22
3ko0P-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 125
GLY A  59
PHE A  36
PHE A  38
 None
 1.12A 3ko0K-2bwgA:
undetectable
3ko0S-2bwgA:
undetectable		 3ko0K-2bwgA:
13.22
3ko0S-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 PHE A 232
VAL A 202
ARG A  34
PRO A  49
 None
 1.46A 3n6dA-2bwgA:
0.0
3n6dB-2bwgA:
0.0		 3n6dA-2bwgA:
23.01
3n6dB-2bwgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 GLY A 172
ALA A 173
ASP A 174
ILE A 175
LEU A 168
 None
 0.90A 3ogpA-2bwgA:
undetectable		 3ogpA-2bwgA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 GLY A 172
ALA A 173
ASP A 174
ILE A 175
LEU A 168
 None
 0.95A 3ogpB-2bwgA:
undetectable		 3ogpB-2bwgA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 GLY A 172
ALA A 173
ASP A 174
ILE A 175
LEU A 168
 None
 0.93A 3ogqB-2bwgA:
undetectable		 3ogqB-2bwgA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 GLY A 172
ALA A 173
ASP A 174
ILE A 175
SER A 105
 None
 1.01A 3ogqB-2bwgA:
undetectable		 3ogqB-2bwgA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 TYR A 297
HIS A 248
GLY A 247
ILE A  50
GLY A 242
 None
None
None
None
5GP  A1340 (-3.6A)
 1.06A 3sudB-2bwgA:
undetectable		 3sudB-2bwgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.97A 3wg7N-2bwgA:
0.0
3wg7W-2bwgA:
undetectable		 3wg7N-2bwgA:
21.02
3wg7W-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 GLY A 195
GLY A 181
VAL A 160
CYH A 186
 None
K  A1339 (-4.8A)
None
5GP  A1340 ( 3.4A)
 0.89A 4c5nA-2bwgA:
undetectable		 4c5nA-2bwgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.41A 4cx7C-2bwgA:
undetectable
4cx7D-2bwgA:
undetectable		 4cx7C-2bwgA:
20.94
4cx7D-2bwgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		3 / 3 TYR A 297
THR A 249
GLU A 257
 None
 0.81A 4df3A-2bwgA:
undetectable		 4df3A-2bwgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		3 / 3 TYR A 297
THR A 249
GLU A 257
 None
 0.80A 4df3B-2bwgA:
undetectable		 4df3B-2bwgA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ASN A 158
GLY A 181
CYH A 186
THR A 188
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
 0.87A 4fo4B-2bwgA:
41.5		 4fo4B-2bwgA:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ASN A 158
GLY A 181
THR A 188
GLY A 290
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.1A)
 0.88A 4fo4B-2bwgA:
41.5		 4fo4B-2bwgA:
33.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 ASN A 158
GLY A 181
CYH A 186
THR A 188
ASP A 219
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-2.3A)
 0.75A 4fxsA-2bwgA:
41.6		 4fxsA-2bwgA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 ASP A 129
ASN A 158
CYH A 186
THR A 188
ASP A 219
 None
5GP  A1340 ( 4.0A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-2.3A)
 0.80A 4fxsA-2bwgA:
41.6		 4fxsA-2bwgA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 LEU A 199
GLY A 235
ALA A 236
ASP A 237
VAL A 178
 None
 1.19A 4njtD-2bwgA:
undetectable		 4njtD-2bwgA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.46A 4nosC-2bwgA:
undetectable
4nosD-2bwgA:
undetectable		 4nosC-2bwgA:
20.75
4nosD-2bwgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ILE A 217
ILE A  51
ASN A  54
ALA A  75
 None
 0.86A 4ou1A-2bwgA:
2.5		 4ou1A-2bwgA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A  76
PHE A  61
VAL A 101
ILE A 116
 None
 0.99A 4zzbC-2bwgA:
undetectable
4zzbD-2bwgA:
undetectable		 4zzbC-2bwgA:
19.17
4zzbD-2bwgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5b1aA-2bwgA:
undetectable
5b1aJ-2bwgA:
undetectable		 5b1aA-2bwgA:
21.02
5b1aJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.92A 5b1bA-2bwgA:
undetectable
5b1bJ-2bwgA:
undetectable		 5b1bA-2bwgA:
21.02
5b1bJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.92A 5b1bN-2bwgA:
undetectable
5b1bW-2bwgA:
undetectable		 5b1bN-2bwgA:
21.02
5b1bW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.93A 5b3sA-2bwgA:
undetectable
5b3sJ-2bwgA:
undetectable		 5b3sA-2bwgA:
21.02
5b3sJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.92A 5b3sN-2bwgA:
0.0
5b3sW-2bwgA:
undetectable		 5b3sN-2bwgA:
21.02
5b3sW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 VAL A 239
SER A 218
ALA A 236
GLY A 233
 None
 0.88A 5fpdB-2bwgA:
undetectable		 5fpdB-2bwgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.89A 5iy5A-2bwgA:
0.0
5iy5J-2bwgA:
undetectable		 5iy5A-2bwgA:
21.02
5iy5J-2bwgA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.89A 5iy5N-2bwgA:
undetectable
5iy5W-2bwgA:
undetectable		 5iy5N-2bwgA:
21.02
5iy5W-2bwgA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 ALA A 206
TYR A 285
GLY A  59
THR A  74
MET A 240
 None
None
None
None
5GP  A1340 (-3.5A)
 1.32A 5jlcA-2bwgA:
undetectable		 5jlcA-2bwgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 ALA A 209
TYR A 285
GLY A  59
THR A  74
MET A 240
 None
None
None
None
5GP  A1340 (-3.5A)
 1.34A 5jlcA-2bwgA:
undetectable		 5jlcA-2bwgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 5 ILE A 154
PHE A 141
SER A 103
ALA A 156
 None
 1.17A 5msdA-2bwgA:
3.6		 5msdA-2bwgA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		3 / 3 THR A 273
MET A 275
HIS A 278
 None
 0.89A 5uunA-2bwgA:
undetectable		 5uunA-2bwgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.90A 5xdqN-2bwgA:
undetectable
5xdqW-2bwgA:
undetectable		 5xdqN-2bwgA:
21.02
5xdqW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5xdxA-2bwgA:
undetectable
5xdxJ-2bwgA:
undetectable		 5xdxA-2bwgA:
21.02
5xdxJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.93A 5z86N-2bwgA:
undetectable
5z86W-2bwgA:
undetectable		 5z86N-2bwgA:
21.02
5z86W-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5zcoA-2bwgA:
undetectable
5zcoJ-2bwgA:
undetectable		 5zcoA-2bwgA:
21.02
5zcoJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 6 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.93A 5zcoN-2bwgA:
undetectable
5zcoW-2bwgA:
undetectable		 5zcoN-2bwgA:
21.02
5zcoW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5zcpA-2bwgA:
undetectable
5zcpJ-2bwgA:
undetectable		 5zcpA-2bwgA:
21.02
5zcpJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5zcqA-2bwgA:
undetectable
5zcqJ-2bwgA:
undetectable		 5zcqA-2bwgA:
21.02
5zcqJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.94A 5zcqN-2bwgA:
undetectable
5zcqW-2bwgA:
undetectable		 5zcqN-2bwgA:
21.02
5zcqW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 LYS A 191
GLY A 290
ASP A  56
MET A  55
 None
5GP  A1340 (-3.1A)
None
5GP  A1340 (-3.9A)
 1.44A 6ag0A-2bwgA:
7.9		 6ag0A-2bwgA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 LYS A 191
GLY A 290
ASP A  56
MET A  55
 None
5GP  A1340 (-3.1A)
None
5GP  A1340 (-3.9A)
 1.47A 6ag0C-2bwgA:
7.1		 6ag0C-2bwgA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.90A 6nmfA-2bwgA:
0.0
6nmfJ-2bwgA:
undetectable		 6nmfA-2bwgA:
21.02
6nmfJ-2bwgA:
10.16