SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		5 / 11 GLU A  49
ARG A  56
LEU A  78
GLU A  81
ALA A  82
 None
 0.93A 1mjlA-2bwjA:
undetectable
1mjlB-2bwjA:
undetectable		 1mjlA-2bwjA:
22.70
1mjlB-2bwjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		5 / 9 LEU A  50
GLU A  81
SER A  41
GLU A  48
ALA A  51
 None
 1.25A 1wrlE-2bwjA:
undetectable
1wrlF-2bwjA:
undetectable		 1wrlE-2bwjA:
23.08
1wrlF-2bwjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		5 / 12 SER A  54
SER A  57
ILE A  60
LEU A  78
VAL A  70
 SO4  A1200 (-4.5A)
None
None
None
None
 0.93A 2nnhA-2bwjA:
undetectable		 2nnhA-2bwjA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		4 / 7 ILE A  14
LEU A  94
PHE A  37
THR A 191
 None
 1.02A 3ag4N-2bwjA:
undetectable
3ag4W-2bwjA:
undetectable		 3ag4N-2bwjA:
17.49
3ag4W-2bwjA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		4 / 8 ARG A 100
LEU A  79
ILE A 112
PHE A 108
 None
 0.94A 3ln1A-2bwjA:
undetectable		 3ln1A-2bwjA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		4 / 7 ARG A 100
LEU A  79
ILE A 112
PHE A 108
 None
 0.93A 3ln1B-2bwjA:
undetectable		 3ln1B-2bwjA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		5 / 12 PHE A 108
THR A  90
LEU A   8
LEU A  40
LEU A  79
 None
 1.43A 4qynB-2bwjA:
undetectable		 4qynB-2bwjA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		4 / 6 ILE A  14
LEU A  94
PHE A  37
THR A 191
 None
 1.04A 5b1aN-2bwjA:
undetectable
5b1aW-2bwjA:
undetectable		 5b1aN-2bwjA:
17.49
5b1aW-2bwjA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bwj ADENYLATE KINASE 5
(Homo
sapiens) 		5 / 9 GLY A 109
TYR A  98
GLU A 106
GLY A 113
PRO A 115
 None
 1.35A 5zniA-2bwjA:
3.1		 5zniA-2bwjA:
18.69