SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 8 GLY A 356
GLY A 327
PHE A 326
GLY A 331
 SO4  A1408 ( 3.9A)
None
None
None
 0.72A 1d0vA-2bwmA:
undetectable		 1d0vA-2bwmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 8 GLY A 356
GLY A 327
PHE A 326
GLY A 331
 SO4  A1408 ( 3.9A)
None
None
None
 0.71A 1jhqA-2bwmA:
undetectable		 1jhqA-2bwmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 8 GLY A 356
GLY A 327
PHE A 326
GLY A 331
 SO4  A1408 ( 3.9A)
None
None
None
 0.75A 1jhvA-2bwmA:
undetectable		 1jhvA-2bwmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 4 GLY A 249
VAL A 247
TRP A 277
GLY A 276
 None
SNG  A1406 (-3.9A)
SNG  A1407 (-3.7A)
SNG  A1407 (-4.4A)
 0.81A 1ng8A-2bwmA:
undetectable		 1ng8A-2bwmA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 4 GLY A 249
VAL A 247
TRP A 277
GLY A 276
 None
SNG  A1406 (-3.9A)
SNG  A1407 (-3.7A)
SNG  A1407 (-4.4A)
 0.81A 1ng8B-2bwmA:
undetectable		 1ng8B-2bwmA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		5 / 12 VAL A 360
ILE A 378
ILE A  38
VAL A 353
LEU A 344
 None
 1.00A 1qhyA-2bwmA:
undetectable		 1qhyA-2bwmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 8 PHE A 150
GLY A 148
GLY A  81
MET A 120
 None
 0.74A 2y6rB-2bwmA:
undetectable		 2y6rB-2bwmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		5 / 8 ALA A 350
ASP A 351
ASP A 343
GLY A 367
VAL A 294
 None
CA  A1401 (-2.3A)
CA  A1401 (-3.2A)
None
None
 1.48A 3em6A-2bwmA:
undetectable		 3em6A-2bwmA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 TYR A 328
ARG A 339
HIS A 337
 None
 1.20A 4fubA-2bwmA:
undetectable		 4fubA-2bwmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		6 / 12 ARG A 167
GLY A 138
GLY A 137
LEU A 157
HIS A 116
VAL A 186
 None
None
None
None
SNG  A1404 (-3.9A)
None
 1.46A 4htfA-2bwmA:
undetectable		 4htfA-2bwmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 5 VAL A 267
LEU A 243
VAL A 286
PHE A 316
 None
 0.94A 4lb0B-2bwmA:
undetectable		 4lb0B-2bwmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		5 / 12 CYH A 285
SER A 287
LEU A   9
PHE A 300
LEU A 289
 None
 1.49A 4o8fB-2bwmA:
0.0		 4o8fB-2bwmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 6 ILE A 352
GLY A 354
ILE A  38
ILE A 374
 None
None
None
GOL  A1410 ( 4.2A)
 0.77A 4o8fB-2bwmA:
undetectable		 4o8fB-2bwmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 LEU A 377
ASP A 379
ILE A 352
 None
 0.65A 4xi3D-2bwmA:
undetectable		 4xi3D-2bwmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		5 / 12 VAL A 341
VAL A 305
ILE A 352
VAL A 250
LEU A 243
 None
 1.02A 4y8wC-2bwmA:
undetectable		 4y8wC-2bwmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ASN A  34
ASP A 347
GLY A 348
 None
CA  A1401 (-3.0A)
None
 0.63A 5fctB-2bwmA:
undetectable		 5fctB-2bwmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ASN A 255
ASP A 181
GLY A 182
 None
CA  A1402 (-3.0A)
None
 0.55A 5fctB-2bwmA:
undetectable		 5fctB-2bwmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		4 / 7 THR A 179
ASP A 181
ASP A 185
GLY A 201
 CA  A1402 (-3.1A)
CA  A1402 (-3.0A)
CA  A1402 (-2.3A)
None
 1.05A 5hwaA-2bwmA:
undetectable		 5hwaA-2bwmA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		5 / 12 PHE A 326
GLY A 301
GLY A 327
GLN A 330
VAL A 283
 None
SNG  A1407 (-3.4A)
None
None
None
 1.01A 5kocB-2bwmA:
undetectable		 5kocB-2bwmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 HIS A 227
SER A 225
ARG A 278
 SNG  A1406 ( 3.8A)
None
None
 0.82A 5u63A-2bwmA:
undetectable		 5u63A-2bwmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		5 / 12 LEU A 377
ALA A 396
THR A  13
ALA A 350
GLY A 346
 None
 0.99A 5veuB-2bwmA:
undetectable		 5veuB-2bwmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ARG A  55
HIS A  59
ARG A  61
 None
SNG  A1403 (-3.7A)
None
 1.14A 6dwdD-2bwmA:
undetectable		 6dwdD-2bwmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ARG A 112
HIS A 116
ARG A 118
 None
SNG  A1404 (-3.9A)
None
 1.11A 6dwdD-2bwmA:
undetectable		 6dwdD-2bwmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ARG A 167
HIS A 171
ARG A 173
 None
SNG  A1405 (-3.9A)
None
 1.12A 6dwdD-2bwmA:
undetectable		 6dwdD-2bwmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ARG A 278
HIS A 282
ARG A 284
 None
SNG  A1407 (-3.9A)
None
 1.09A 6dwdD-2bwmA:
undetectable		 6dwdD-2bwmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ARG A 333
HIS A 337
ARG A 339
 None
 1.14A 6dwdD-2bwmA:
undetectable		 6dwdD-2bwmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2bwm PSATHYRELLA VELUTINA
LECTIN PVL
(Lacrymaria
velutina) 		3 / 3 ASP A 181
ASP A 237
ASN A 310
 CA  A1402 (-3.0A)
None
None
 0.84A 6gngB-2bwmA:
undetectable		 6gngB-2bwmA:
20.48