SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 331
ALA A 333
SER A 327
 None
 0.59A 1errB-2bx6A:
undetectable		 1errB-2bx6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 168
PHE A 340
VAL A 270
 None
 0.73A 1kijA-2bx6A:
undetectable		 1kijA-2bx6A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 102
LEU A 112
LEU A 129
 None
 0.56A 1mx1E-2bx6A:
undetectable		 1mx1E-2bx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 254
GLN A 266
ILE A 166
PHE A 167
LEU A 300
 None
 0.90A 2aclG-2bx6A:
undetectable		 2aclG-2bx6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		4 / 5 PHE A  75
PHE A  92
PHE A 148
VAL A 212
 None
 1.24A 2lh6A-2bx6A:
0.9		 2lh6A-2bx6A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 254
GLN A 266
ILE A 166
PHE A 167
LEU A 300
 None
 0.90A 3dzuA-2bx6A:
undetectable		 3dzuA-2bx6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		4 / 7 CYH A 130
PHE A 167
PHE A 159
SER A 165
 None
 1.40A 3hggA-2bx6A:
1.0		 3hggA-2bx6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 117
CYH A 130
CYH A 131
THR A 170
VAL A 119
 None
 1.50A 3sp6A-2bx6A:
undetectable		 3sp6A-2bx6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 125
VAL A 127
PHE A 117
VAL A 119
CYH A 110
 None
 1.22A 3u9fJ-2bx6A:
undetectable
3u9fK-2bx6A:
undetectable		 3u9fJ-2bx6A:
18.52
3u9fK-2bx6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 CYH A 110
LEU A 125
VAL A 127
PHE A 117
VAL A 119
 None
 1.22A 3u9fP-2bx6A:
undetectable
3u9fS-2bx6A:
undetectable		 3u9fP-2bx6A:
18.52
3u9fS-2bx6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		4 / 6 THR A  87
ASN A  88
CYH A 108
ILE A  72
 None
 1.24A 3w9tB-2bx6A:
undetectable		 3w9tB-2bx6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 189
LEU A 188
ARG A 228
ILE A 137
LEU A 125
 None
None
SO4  A1348 (-3.9A)
None
None
 1.27A 4j24C-2bx6A:
undetectable		 4j24C-2bx6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		4 / 6 ILE A 298
PHE A 167
ARG A 251
ILE A 254
 None
 1.30A 4zzcA-2bx6A:
undetectable
4zzcB-2bx6A:
undetectable		 4zzcA-2bx6A:
19.34
4zzcB-2bx6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		4 / 6 ILE A 298
PHE A 167
ARG A 251
ILE A 254
 None
 1.25A 4zzcB-2bx6A:
undetectable
4zzcC-2bx6A:
undetectable		 4zzcB-2bx6A:
19.34
4zzcC-2bx6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 345
ALA A 344
PHE A 340
TRP A 171
ASN A 169
 None
 1.36A 5c8tB-2bx6A:
0.0		 5c8tB-2bx6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 254
ILE A 166
PHE A 167
LEU A 300
ALA A 299
 None
 1.12A 6a5zD-2bx6A:
undetectable		 6a5zD-2bx6A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2bx6 XRP2 PROTEIN
(Homo
sapiens) 		5 / 10 PHE A  62
GLY A  94
ILE A  74
ILE A  64
ILE A  83
 None
 1.12A 6ebpD-2bx6A:
undetectable		 6ebpD-2bx6A:
12.77