SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 GLY A 271
ILE A 270
ALA A 228
ILE A 224
 FMN  A1312 (-3.4A)
None
None
FMN  A1312 ( 4.9A)
 0.78A 1n49A-2bx7A:
undetectable		 1n49A-2bx7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 GLY A 249
VAL A 192
GLU A 125
ILE A 224
 FMN  A1312 (-3.5A)
None
None
FMN  A1312 ( 4.9A)
 0.91A 1pk7B-2bx7A:
undetectable		 1pk7B-2bx7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.99A 1v54A-2bx7A:
0.0
1v54J-2bx7A:
undetectable		 1v54A-2bx7A:
19.78
1v54J-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.98A 1v54N-2bx7A:
undetectable
1v54W-2bx7A:
undetectable		 1v54N-2bx7A:
19.78
1v54W-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 SER A  44
LEU A  71
GLY A  52
ILE A 210
 FMN  A1312 (-2.6A)
ACT  A1313 ( 4.7A)
None
None
 0.99A 2bdmA-2bx7A:
undetectable		 2bdmA-2bx7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.99A 2dyrA-2bx7A:
undetectable
2dyrJ-2bx7A:
undetectable		 2dyrA-2bx7A:
19.78
2dyrJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.97A 2dyrN-2bx7A:
undetectable
2dyrW-2bx7A:
undetectable		 2dyrN-2bx7A:
19.78
2dyrW-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.98A 2dysA-2bx7A:
0.0
2dysJ-2bx7A:
undetectable		 2dysA-2bx7A:
19.78
2dysJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.97A 2dysN-2bx7A:
0.0
2dysW-2bx7A:
undetectable		 2dysN-2bx7A:
19.78
2dysW-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.99A 2eijA-2bx7A:
undetectable
2eijJ-2bx7A:
undetectable		 2eijA-2bx7A:
19.78
2eijJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 1.00A 2eikA-2bx7A:
0.0
2eikJ-2bx7A:
undetectable		 2eikA-2bx7A:
19.78
2eikJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 1.00A 2eilA-2bx7A:
0.0
2eilJ-2bx7A:
undetectable		 2eilA-2bx7A:
19.78
2eilJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 GLU A 288
ILE A 285
GLU A 277
ILE A 281
 None
 0.93A 2j9dJ-2bx7A:
0.0
2j9dK-2bx7A:
undetectable
2j9dL-2bx7A:
undetectable		 2j9dJ-2bx7A:
17.42
2j9dK-2bx7A:
17.42
2j9dL-2bx7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 ILE A 224
ALA A 273
GLY A 271
GLY A 220
VAL A  21
 FMN  A1312 ( 4.9A)
None
FMN  A1312 (-3.4A)
FMN  A1312 ( 3.8A)
None
 1.18A 2okcB-2bx7A:
undetectable		 2okcB-2bx7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 161
LEU A 186
PHE A 154
LEU A 112
 None
 0.95A 2vq5B-2bx7A:
undetectable		 2vq5B-2bx7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.99A 2zxwA-2bx7A:
0.0
2zxwJ-2bx7A:
undetectable		 2zxwA-2bx7A:
19.78
2zxwJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.98A 3ablA-2bx7A:
0.0
3ablJ-2bx7A:
undetectable		 3ablA-2bx7A:
19.78
3ablJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 1.00A 3abmA-2bx7A:
undetectable
3abmJ-2bx7A:
undetectable		 3abmA-2bx7A:
19.78
3abmJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 1.01A 3asnA-2bx7A:
0.0
3asnJ-2bx7A:
undetectable		 3asnA-2bx7A:
19.78
3asnJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.99A 3asoA-2bx7A:
0.0
3asoJ-2bx7A:
undetectable		 3asoA-2bx7A:
19.78
3asoJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 ASN A  90
LYS A  88
PRO A  95
PHE A  11
 None
 1.48A 3bjwD-2bx7A:
undetectable		 3bjwD-2bx7A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 TYR A 223
ASP A 256
GLN A 255
GLU A 288
 None
 0.96A 3dh0A-2bx7A:
undetectable		 3dh0A-2bx7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 5 ASN A 193
THR A 124
SER A  99
SER A  45
 ACT  A1313 ( 3.1A)
None
FMN  A1312 ( 4.5A)
None
 1.32A 3hlwB-2bx7A:
undetectable		 3hlwB-2bx7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 HIS A 260
GLY A 220
GLY A 221
LEU A  63
ALA A 228
 None
FMN  A1312 ( 3.8A)
FMN  A1312 (-3.6A)
None
None
 1.20A 3i5uA-2bx7A:
undetectable		 3i5uA-2bx7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 HIS A 260
GLY A 220
GLY A 221
LEU A  63
ALA A 228
 None
FMN  A1312 ( 3.8A)
FMN  A1312 (-3.6A)
None
None
 1.20A 3i5uB-2bx7A:
undetectable		 3i5uB-2bx7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 ALA A 257
LEU A 268
GLY A 271
ALA A 273
ILE A 285
 None
None
FMN  A1312 (-3.4A)
None
None
 1.15A 3lbdA-2bx7A:
undetectable		 3lbdA-2bx7A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 LEU A 268
MET A 267
ILE A 246
GLY A  38
ILE A 285
 None
 1.31A 3lbdA-2bx7A:
undetectable		 3lbdA-2bx7A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		3 / 3 LYS A 276
THR A 272
ILE A 224
 None
FMN  A1312 (-3.7A)
FMN  A1312 ( 4.9A)
 0.88A 4e0fB-2bx7A:
undetectable		 4e0fB-2bx7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 GLY A  94
MET A  16
PHE A  97
ILE A 123
 None
 1.01A 4j4vC-2bx7A:
undetectable		 4j4vC-2bx7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 11 GLY A 249
GLY A 250
GLY A 221
ALA A 228
HIS A 260
 FMN  A1312 (-3.5A)
FMN  A1312 (-3.8A)
FMN  A1312 (-3.6A)
None
None
 1.18A 4l8fB-2bx7A:
undetectable		 4l8fB-2bx7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 11 GLY A 249
GLY A 250
GLY A 221
ALA A 228
HIS A 260
 FMN  A1312 (-3.5A)
FMN  A1312 (-3.8A)
FMN  A1312 (-3.6A)
None
None
 1.17A 4l8fD-2bx7A:
undetectable		 4l8fD-2bx7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 SER A 129
ILE A 219
GLY A 221
SER A  19
ASN A  67
 ACT  A1313 ( 4.9A)
None
FMN  A1312 (-3.6A)
FMN  A1312 (-3.3A)
FMN  A1312 (-3.7A)
 1.29A 4obwC-2bx7A:
undetectable		 4obwC-2bx7A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 GLU A 147
THR A 146
LEU A 239
ASN A 182
 None
 1.09A 4pfjA-2bx7A:
undetectable		 4pfjA-2bx7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
THR A 124
LEU A 165
SER A 191
 None
 0.97A 4pwjA-2bx7A:
undetectable		 4pwjA-2bx7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 THR A 248
GLY A 220
GLY A 221
ASP A 256
 FMN  A1312 (-4.2A)
FMN  A1312 ( 3.8A)
FMN  A1312 (-3.6A)
None
 0.72A 4qvvK-2bx7A:
undetectable
4qvvL-2bx7A:
undetectable		 4qvvK-2bx7A:
21.47
4qvvL-2bx7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 THR A 248
GLY A 220
GLY A 221
ASP A 256
 FMN  A1312 (-4.2A)
FMN  A1312 ( 3.8A)
FMN  A1312 (-3.6A)
None
 0.73A 4qvvY-2bx7A:
undetectable
4qvvZ-2bx7A:
undetectable		 4qvvY-2bx7A:
21.47
4qvvZ-2bx7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.98A 5b1bA-2bx7A:
undetectable
5b1bJ-2bx7A:
undetectable		 5b1bA-2bx7A:
19.78
5b1bJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 LEU A  71
SER A  99
GLU A 125
SER A  65
GLY A 221
 ACT  A1313 ( 4.7A)
FMN  A1312 ( 4.5A)
None
FMN  A1312 ( 4.2A)
FMN  A1312 (-3.6A)
 1.37A 5f9zB-2bx7A:
undetectable		 5f9zB-2bx7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 ILE A 224
GLY A 221
PHE A  15
ASP A 256
 FMN  A1312 ( 4.9A)
FMN  A1312 (-3.6A)
None
None
 1.01A 5hieA-2bx7A:
undetectable		 5hieA-2bx7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 PHE A 184
ILE A 180
LEU A 150
LEU A 128
VAL A 163
 None
 1.26A 5im2A-2bx7A:
undetectable		 5im2A-2bx7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 1.06A 5x1fA-2bx7A:
undetectable
5x1fJ-2bx7A:
undetectable		 5x1fA-2bx7A:
19.78
5x1fJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 0.97A 5xdqA-2bx7A:
0.0
5xdqJ-2bx7A:
undetectable		 5xdqA-2bx7A:
19.78
5xdqJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 GLY A 218
GLY A 220
LEU A 199
GLY A 198
GLY A 217
 None
FMN  A1312 ( 3.8A)
None
None
None
 0.90A 5zhmB-2bx7A:
undetectable		 5zhmB-2bx7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2bx7 DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 11 PHE A  15
ILE A 270
LEU A 268
ILE A 292
MET A 293
 None
 1.36A 6fgcA-2bx7A:
undetectable		 6fgcA-2bx7A:
17.59