SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 8 THR A 548
GLY A 553
LEU A 527
ASP A 524
 None
 0.83A 1aegA-2bxyA:
undetectable		 1aegA-2bxyA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 177
ASP A 275
ALA A 276
HIS A 399
ASP A 400
 None
 0.63A 1dedA-2bxyA:
26.6		 1dedA-2bxyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 TYR A 177
ARG A 273
ASP A 275
ALA A 276
HIS A 399
ASP A 400
 None
 0.63A 1dedB-2bxyA:
31.4		 1dedB-2bxyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 TYR A 177
ARG A 273
ASP A 275
GLU A 308
HIS A 399
ASP A 400
 None
 0.83A 1dedB-2bxyA:
31.4		 1dedB-2bxyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 403
LEU A 407
PRO A 484
VAL A 483
PHE A 472
 None
 1.17A 1gseA-2bxyA:
undetectable		 1gseA-2bxyA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 9 HIS A 303
LEU A 264
ALA A 260
LEU A 272
LEU A 292
 None
 1.30A 1hwiA-2bxyA:
undetectable		 1hwiA-2bxyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 7 TYR A 130
ILE A 396
GLU A 443
LEU A 518
 None
 0.94A 1j96B-2bxyA:
9.2		 1j96B-2bxyA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 TYR A 130
ILE A 396
GLU A 443
LEU A 518
LEU A 430
 None
 1.05A 1mrqA-2bxyA:
9.2		 1mrqA-2bxyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		8 / 12 TRP A 175
TYR A 177
HIS A 217
ARG A 273
ASP A 275
GLU A 308
HIS A 399
ASP A 400
 None
 1.14A 1mxdA-2bxyA:
24.8		 1mxdA-2bxyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 PHE A 137
ALA A 202
VAL A 163
LEU A 166
LEU A 195
 None
 1.13A 1rlbF-2bxyA:
0.0		 1rlbF-2bxyA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		3 / 3 GLU A 443
GLU A 155
LEU A 207
 None
 0.75A 1v8bB-2bxyA:
undetectable		 1v8bB-2bxyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		3 / 3 PHE A 492
TYR A 189
TYR A 186
 None
 0.99A 1x70B-2bxyA:
0.4		 1x70B-2bxyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 8 VAL A 158
THR A 435
PRO A 436
LEU A 438
 None
 1.03A 1z2bB-2bxyA:
undetectable		 1z2bB-2bxyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 LEU A 299
ILE A 296
HIS A 203
ASP A 116
HIS A 268
 None
 1.24A 1zz1A-2bxyA:
undetectable		 1zz1A-2bxyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 7 ARG A 361
GLU A 533
ASN A 529
ALA A 389
 None
 1.28A 2ejgA-2bxyA:
undetectable		 2ejgA-2bxyA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 TYR A 177
ASP A 275
HIS A 399
ASP A 400
TRP A 175
 None
 0.94A 2owcA-2bxyA:
19.7		 2owcA-2bxyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 TYR A 177
ASP A 275
HIS A 399
ASP A 400
TRP A 175
 None
 0.93A 2owwA-2bxyA:
19.7		 2owwA-2bxyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		3 / 3 LEU A 195
LEU A 150
PHE A 269
 None
 0.69A 2pgrA-2bxyA:
4.6		 2pgrA-2bxyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 10 MET A 262
ALA A 260
TYR A 215
PHE A 269
GLY A 258
 None
 1.04A 2zm8A-2bxyA:
0.0		 2zm8A-2bxyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.72A 3aicA-2bxyA:
5.4		 3aicA-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.73A 3aicB-2bxyA:
7.1		 3aicB-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		7 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
TYR A 177
 None
 0.68A 3aicC-2bxyA:
5.2		 3aicC-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.77A 3aicD-2bxyA:
6.4		 3aicD-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.76A 3aicE-2bxyA:
5.0		 3aicE-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.70A 3aicF-2bxyA:
3.4		 3aicF-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.70A 3aicG-2bxyA:
5.2		 3aicG-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 ARG A 273
ASP A 275
ALA A 276
GLU A 308
HIS A 399
ASP A 400
 None
 0.79A 3aicH-2bxyA:
5.2		 3aicH-2bxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 THR A 257
ALA A 260
LEU A 305
LEU A 272
MET A 280
 None
 1.03A 3hm1A-2bxyA:
undetectable		 3hm1A-2bxyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 10 LEU A 272
ILE A 161
VAL A 163
VAL A 213
LEU A 211
 None
 1.09A 3ogpB-2bxyA:
undetectable		 3ogpB-2bxyA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 430
THR A 431
GLY A 424
ALA A 425
LEU A 513
 None
 1.19A 3p5nA-2bxyA:
undetectable		 3p5nA-2bxyA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 ALA A 104
GLY A  26
ALA A  27
THR A  36
VAL A  73
 None
 1.13A 3rukD-2bxyA:
undetectable		 3rukD-2bxyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 MET A 262
ALA A 260
TYR A 215
PHE A 269
GLY A 258
 None
 1.05A 3vwqA-2bxyA:
undetectable		 3vwqA-2bxyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 MET A 262
ALA A 260
TYR A 215
PHE A 269
GLY A 258
 None
 1.05A 3vwrA-2bxyA:
0.0		 3vwrA-2bxyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 6 ILE A 396
LEU A 411
TYR A 514
THR A 585
 None
 1.12A 3wg7A-2bxyA:
undetectable
3wg7J-2bxyA:
undetectable		 3wg7A-2bxyA:
20.61
3wg7J-2bxyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 6 TYR A 514
HIS A 412
TYR A 422
TYR A 130
 None
 1.44A 4df2A-2bxyA:
6.9		 4df2A-2bxyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 5 PHE A 210
ILE A 122
GLY A 121
THR A 302
 None
 0.99A 4ejjC-2bxyA:
undetectable		 4ejjC-2bxyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 GLY A 208
GLY A 121
ASP A 270
ILE A 161
ALA A 202
LEU A 198
 None
 1.34A 4iv8A-2bxyA:
undetectable		 4iv8A-2bxyA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 GLY A 208
GLY A 121
ASP A 270
ILE A 161
ALA A 202
LEU A 198
 None
 1.34A 4iv8B-2bxyA:
undetectable		 4iv8B-2bxyA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 450
PRO A 449
THR A 448
ARG A 410
GLU A 501
 None
 1.33A 4k88A-2bxyA:
undetectable		 4k88A-2bxyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 273
GLY A 381
PRO A 278
THR A 277
 None
 0.83A 4l1aB-2bxyA:
undetectable		 4l1aB-2bxyA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 9 TYR A 130
ILE A 396
GLU A 443
LEU A 518
LEU A 430
 None
 1.04A 4l1xB-2bxyA:
8.9		 4l1xB-2bxyA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 VAL A 199
VAL A 132
ALA A 146
LEU A 150
LEU A 153
 None
 1.01A 4m11B-2bxyA:
undetectable		 4m11B-2bxyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 8 PRO A 192
PHE A 109
PHE A  95
TYR A  79
 None
 1.39A 4v2zC-2bxyA:
0.0		 4v2zC-2bxyA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 450
PRO A 449
THR A 448
ARG A 410
GLU A 501
 None
 1.46A 4ydqB-2bxyA:
undetectable		 4ydqB-2bxyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		3 / 3 LEU A 513
ARG A 512
ARG A 509
 None
 0.97A 4yiaB-2bxyA:
undetectable		 4yiaB-2bxyA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 11 TYR A 130
ILE A 396
GLU A 443
LEU A 518
LEU A 430
 None
 0.91A 4yvpA-2bxyA:
9.2		 4yvpA-2bxyA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 10 ALA A 180
GLY A  99
LEU A  96
ALA A  93
ASP A  90
 None
 0.94A 5ajqB-2bxyA:
2.2		 5ajqB-2bxyA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 ARG A 273
ASP A 275
GLU A 308
HIS A 399
ASP A 400
 None
 0.41A 5csyB-2bxyA:
7.8		 5csyB-2bxyA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 8 LEU A 430
LEU A 527
ARG A 530
LEU A 583
 None
 1.16A 5dxeA-2bxyA:
undetectable		 5dxeA-2bxyA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 6 LEU A 557
LEU A 428
LEU A 517
HIS A 584
 None
 0.92A 5gs4A-2bxyA:
undetectable		 5gs4A-2bxyA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 ALA A 353
GLY A 541
GLY A 538
GLY A 562
LEU A 428
 None
MG  A1609 ( 4.6A)
None
None
None
 1.11A 5gwxA-2bxyA:
2.0		 5gwxA-2bxyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 10 ALA A 167
TYR A 189
GLY A 171
GLY A 176
VAL A 100
 None
 1.20A 5i6xA-2bxyA:
undetectable		 5i6xA-2bxyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 8 ALA A 357
LEU A 535
LEU A 428
LEU A 432
 None
 0.71A 5jqbA-2bxyA:
undetectable
5jqbB-2bxyA:
undetectable		 5jqbA-2bxyA:
19.40
5jqbB-2bxyA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		3 / 3 ASP A 329
ASN A 398
GLN A 401
 None
BME  A1608 (-4.3A)
None
 0.75A 5k7uA-2bxyA:
undetectable		 5k7uA-2bxyA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		3 / 3 TYR A  92
HIS A 251
MET A 252
 None
GLC  A1606 (-4.2A)
None
 1.16A 6af6A-2bxyA:
undetectable		 6af6A-2bxyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		6 / 12 TYR A 177
HIS A 217
GLU A 376
ASP A 275
HIS A 399
ASP A 400
 None
None
GLC  A1605 (-2.8A)
None
None
None
 0.87A 6ag0A-2bxyA:
25.2		 6ag0A-2bxyA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 376
HIS A 310
TYR A 346
HIS A 399
ASP A 400
 GLC  A1605 (-2.8A)
GLC  A1605 (-4.2A)
None
None
None
 1.08A 6ag0C-2bxyA:
24.9		 6ag0C-2bxyA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		5 / 12 TRP A 175
GLU A 376
ASP A 275
HIS A 399
ASP A 400
 None
GLC  A1605 (-2.8A)
None
None
None
 1.24A 6ag0C-2bxyA:
24.9		 6ag0C-2bxyA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 8 LEU A 430
LEU A 527
ARG A 530
LEU A 583
 None
 1.17A 6cbzA-2bxyA:
undetectable		 6cbzA-2bxyA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE
(Deinococcus
radiodurans) 		4 / 5 GLU A 421
VAL A 417
LEU A 411
HIS A 331
 TRS  A1603 (-2.6A)
TRS  A1603 (-4.0A)
None
None
 1.45A 6dyoA-2bxyA:
undetectable		 6dyoA-2bxyA:
8.31