SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2byg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		5 / 11 LEU A 203
GLY A 204
SER A 206
ILE A 207
VAL A 262
 None
 0.86A 2kawA-2bygA:
12.3		 2kawA-2bygA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		6 / 12 GLY A 231
ALA A 233
ASP A 236
ILE A 194
VAL A 241
ILE A 227
 None
 1.50A 3d1yA-2bygA:
undetectable		 3d1yA-2bygA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		6 / 12 GLY A 231
ALA A 233
ASP A 236
ILE A 194
VAL A 241
ILE A 227
 None
 1.46A 3k4vA-2bygA:
undetectable		 3k4vA-2bygA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		6 / 12 GLY A 231
ALA A 233
ASP A 236
ILE A 194
VAL A 241
ILE A 227
 None
 1.45A 3ndtA-2bygA:
undetectable		 3ndtA-2bygA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		6 / 11 GLY A 231
ALA A 233
ASP A 236
ILE A 194
VAL A 241
ILE A 227
 None
 1.49A 3ndxB-2bygA:
undetectable		 3ndxB-2bygA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		6 / 12 GLY A 231
ALA A 233
ASP A 236
ILE A 194
VAL A 241
ILE A 227
 None
 1.50A 3tl9A-2bygA:
undetectable		 3tl9A-2bygA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110
(Homo
sapiens) 		4 / 5 GLN A 214
ASP A 219
SER A 221
ARG A 244
 None
 1.39A 5w4zA-2bygA:
undetectable		 5w4zA-2bygA:
15.38