SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2byk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2byk CHRAC-14
CHRAC-16
(Drosophila
melanogaster) 		5 / 11 PHE B  81
SER B  80
PHE A  91
LEU A  89
VAL A  82
 None
 1.14A 1q23L-2bykB:
undetectable		 1q23L-2bykB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2byk CHRAC-14
CHRAC-16
(Drosophila
melanogaster) 		5 / 12 VAL A  82
VAL B  29
GLY A  59
ALA A  60
LEU A  89
 None
 0.96A 1r9oA-2bykA:
undetectable		 1r9oA-2bykA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2byk CHRAC-14
CHRAC-16
(Drosophila
melanogaster) 		5 / 11 ARG B  17
ILE B  37
LEU A  79
ARG A  55
GLY A  59
 None
 1.16A 2bxmA-2bykB:
undetectable		 2bxmA-2bykB:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2byk CHRAC-14
CHRAC-16
(Drosophila
melanogaster) 		4 / 6 THR A  63
PHE A  66
LEU B  23
LEU A  74
 None
 1.04A 3bgdA-2bykA:
undetectable		 3bgdA-2bykA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2byk CHRAC-14
CHRAC-16
(Drosophila
melanogaster) 		4 / 8 GLU A  41
VAL B  82
LEU B  85
PHE A  44
 None
 0.89A 4r3aA-2bykA:
undetectable		 4r3aA-2bykA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2byk CHRAC-14
CHRAC-16
(Drosophila
melanogaster) 		5 / 12 VAL A  82
VAL B  29
GLY A  59
ALA A  60
LEU A  89
 None
 1.03A 5xxiA-2bykA:
undetectable		 5xxiA-2bykA:
17.18