SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2byo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 125
SER A  31
LEU A 131
LEU A  25
 None
 1.15A 1yajA-2byoA:
undetectable		 1yajA-2byoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  24
ILE A  28
ILE A 173
ALA A 133
LEU A 131
 None
HXA  A1215 ( 4.8A)
None
None
None
 1.16A 2m9qA-2byoA:
undetectable		 2m9qA-2byoA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  84
VAL A  62
HIS A  42
 OAA  A1218 (-4.4A)
None
ZN  A1213 ( 2.9A)
 0.84A 4pevC-2byoA:
undetectable		 4pevC-2byoA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  92
VAL A  94
ILE A  57
THR A  76
 None
None
LNL  A1216 ( 4.2A)
None
 0.98A 6cduF-2byoA:
undetectable
6cduG-2byoA:
undetectable		 6cduF-2byoA:
23.31
6cduG-2byoA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  92
VAL A  94
ILE A  57
THR A  76
 None
None
LNL  A1216 ( 4.2A)
None
 1.04A 6cduG-2byoA:
undetectable
6cduH-2byoA:
undetectable		 6cduG-2byoA:
23.31
6cduH-2byoA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2byo LIPOPROTEIN LPPX
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 184
VAL A 171
ARG A 183
ASP A 140
 LNL  A1217 ( 4.1A)
HXA  A1215 ( 4.4A)
None
None
 0.99A 6hu9a-2byoA:
undetectable
6hu9e-2byoA:
undetectable		 6hu9a-2byoA:
19.35
6hu9e-2byoA:
23.76