SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 ILE A 149
PHE A 178
LEU A 174
PHE A 171
 None
 0.77A 2vdbA-2bzgA:
undetectable		 2vdbA-2bzgA:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 6 PHE A  40
ARG A 152
GLY A 153
ALA A 157
LEU A 185
PRO A 196
 SAH  A1246 (-3.4A)
SAH  A1246 (-4.0A)
SAH  A1246 (-3.9A)
SAH  A1246 ( 3.7A)
None
None
 0.27A 3bgdA-2bzgA:
39.3		 3bgdA-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 6 HIS A  52
THR A  55
GLN A 179
LEU A 217
LEU A 241
 None
 0.52A 3bgdA-2bzgA:
39.3		 3bgdA-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 PHE A  40
ARG A 152
GLY A 153
VAL A 156
LEU A 185
PRO A 196
 SAH  A1246 (-3.4A)
SAH  A1246 (-4.0A)
SAH  A1246 (-3.9A)
None
None
None
 0.35A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 PHE A  40
GLY A 153
VAL A 156
LEU A 185
PRO A 196
ARG A 226
 SAH  A1246 (-3.4A)
SAH  A1246 (-3.9A)
None
None
None
None
 0.62A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 8 PHE A  40
VAL A 156
PRO A 196
ARG A 226
TRP A 230
 SAH  A1246 (-3.4A)
None
None
None
None
 0.78A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 7 HIS A  52
THR A  55
GLN A 179
LEU A 217
LEU A 241
 None
 0.55A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 THR A  55
GLN A 179
LEU A 181
LEU A 241
 None
 0.88A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 GLU A 244
LYS A 245
ASN A 213
ILE A 211
 None
 1.25A 3kp6A-2bzgA:
undetectable
3kp6B-2bzgA:
undetectable		 3kp6A-2bzgA:
19.57
3kp6B-2bzgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A 126
PHE A  99
PHE A 100
LEU A 105
 None
 0.75A 3v7pA-2bzgA:
undetectable		 3v7pA-2bzgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 185
GLY A 153
TRP A 150
ARG A 226
ILE A 204
 None
SAH  A1246 (-3.9A)
None
None
None
 1.46A 4udcA-2bzgA:
undetectable		 4udcA-2bzgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 243
THR A  55
HIS A  52
LEU A 181
 None
 1.25A 6aphA-2bzgA:
3.2		 6aphA-2bzgA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 243
THR A  55
HIS A  52
LEU A 181
 None
 1.25A 6gbnB-2bzgA:
3.2		 6gbnB-2bzgA:
19.05