SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		3 / 3 TRP A1077
ALA A1010
VAL A1008
 None
 0.99A 1bdwA-2bzlA:
undetectable
1bdwB-2bzlA:
undetectable		 1bdwA-2bzlA:
4.94
1bdwB-2bzlA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 6 GLN A1169
CYH A1121
VAL A1008
GLY A1129
 EDO  A2187 (-3.3A)
EDO  A2187 (-3.4A)
None
None
 1.17A 1ekjC-2bzlA:
undetectable
1ekjD-2bzlA:
undetectable		 1ekjC-2bzlA:
19.29
1ekjD-2bzlA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 6 CYH A1121
VAL A1008
GLY A1129
GLN A1169
 EDO  A2187 (-3.4A)
None
None
EDO  A2187 (-3.3A)
 1.14A 1ekjC-2bzlA:
undetectable
1ekjD-2bzlA:
undetectable		 1ekjC-2bzlA:
19.29
1ekjD-2bzlA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 8 LEU A1177
TYR A1174
LYS A 903
LEU A1133
 None
 1.09A 1hk3A-2bzlA:
undetectable		 1hk3A-2bzlA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 4 SER A1134
VAL A1149
PHE A1172
VAL A1086
 None
 1.44A 1o86A-2bzlA:
undetectable		 1o86A-2bzlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		3 / 3 GLU A1094
GLU A1135
LEU A1177
 None
 0.64A 1v8bB-2bzlA:
undetectable		 1v8bB-2bzlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 8 TYR A 913
ILE A 916
LEU A1133
VAL A1130
 None
 0.89A 2w98B-2bzlA:
undetectable		 2w98B-2bzlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 12 ILE A 980
THR A 982
VAL A1118
GLU A 999
PRO A1116
 None
 1.30A 2yzqA-2bzlA:
undetectable		 2yzqA-2bzlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 6 VAL A 943
GLN A1165
GLY A1129
ARG A1127
 None
None
None
EDO  A2187 (-4.7A)
 0.93A 3bjwE-2bzlA:
undetectable		 3bjwE-2bzlA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 11 ILE A 980
ILE A1005
ILE A 963
VAL A1002
PRO A1116
 None
 0.97A 3tmzA-2bzlA:
undetectable		 3tmzA-2bzlA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 8 ILE A1096
LEU A1093
VAL A1130
GLY A1129
MET A1163
 None
 1.41A 3w1wA-2bzlA:
undetectable		 3w1wA-2bzlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		3 / 3 ARG A1154
TYR A 979
ASN A 948
 None
 0.88A 4ffwB-2bzlA:
undetectable		 4ffwB-2bzlA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 8 ILE A 916
LEU A1153
ILE A1167
GLY A1126
 None
None
None
EDO  A2187 (-3.5A)
 0.83A 4hb8A-2bzlA:
undetectable		 4hb8A-2bzlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 5 GLN A1087
LEU A1090
SER A1091
ASP A1076
 None
 1.29A 4qtuD-2bzlA:
undetectable		 4qtuD-2bzlA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 12 THR A1009
THR A1128
SER A1019
GLY A 984
ALA A1123
 None
 1.36A 5lf3b-2bzlA:
undetectable		 5lf3b-2bzlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 12 THR A1009
THR A1128
SER A1019
GLY A 984
ALA A1123
 None
 1.36A 5lf3N-2bzlA:
undetectable		 5lf3N-2bzlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 9 LEU A1093
GLY A1088
VAL A1130
LEU A1131
ARG A1127
 None
None
None
None
EDO  A2187 (-4.7A)
 1.26A 5o96E-2bzlA:
undetectable
5o96F-2bzlA:
undetectable		 5o96E-2bzlA:
22.62
5o96F-2bzlA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 12 ARG A1157
ILE A1164
ILE A1096
TYR A1092
LEU A1093
 None
 1.10A 5y2tB-2bzlA:
undetectable		 5y2tB-2bzlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		5 / 12 VAL A 942
GLU A1013
PRO A1083
VAL A1173
PHE A1172
 None
 1.47A 6becA-2bzlA:
undetectable
6becB-2bzlA:
undetectable
6becC-2bzlA:
undetectable		 6becA-2bzlA:
20.47
6becB-2bzlA:
20.47
6becC-2bzlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens) 		4 / 7 ILE A 980
GLN A1000
VAL A1002
ILE A1117
 None
 1.00A 6cduF-2bzlA:
undetectable
6cduG-2bzlA:
undetectable		 6cduF-2bzlA:
21.58
6cduG-2bzlA:
21.58