SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 GLY A  47
ILE A  50
LEU A  72
ASP A 237
 None
 0.84A 1jg4A-2bznA:
undetectable		 1jg4A-2bznA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 12 MET A 269
GLY A 183
MET A 240
THR A  57
PHE A 266
 None
IMP  A1338 (-3.4A)
IMP  A1338 (-3.5A)
None
None
 1.41A 1m2zA-2bznA:
undetectable		 1m2zA-2bznA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ASN A 158
ILE A 180
GLY A 181
CYH A 186
 IMP  A1338 ( 4.3A)
None
None
IMP  A1338 (-2.5A)
 0.37A 1me7A-2bznA:
38.0		 1me7A-2bznA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ASP A 129
ILE A 180
GLY A 181
CYH A 186
 None
None
None
IMP  A1338 (-2.5A)
 0.63A 1me7A-2bznA:
38.0		 1me7A-2bznA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 7 ASP A 237
ILE A 154
ALA A  75
ILE A  51
 None
 0.69A 1n49A-2bznA:
undetectable		 1n49A-2bznA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 12 ALA A 234
ALA A 236
LEU A  72
GLY A 233
PHE A 333
 None
 1.10A 1qabF-2bznA:
undetectable		 1qabF-2bznA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 12 ILE A 305
VAL A 228
ALA A 229
PHE A 232
LEU A 324
 None
 0.96A 1uduB-2bznA:
undetectable		 1uduB-2bznA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 6 ILE A 334
VAL A 239
ILE A 312
ILE A  50
ASP A 227
 None
 1.39A 1uwhB-2bznA:
undetectable		 1uwhB-2bznA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		3 / 3 ILE A  51
ASP A 237
PHE A 232
 None
 0.64A 1uwjB-2bznA:
undetectable		 1uwjB-2bznA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 5 ASP A 237
GLY A 211
VAL A 202
ILE A 216
 None
 1.00A 2aoiA-2bznA:
undetectable		 2aoiA-2bznA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.46A 2nsiA-2bznA:
undetectable
2nsiB-2bznA:
undetectable		 2nsiA-2bznA:
22.17
2nsiB-2bznA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.49A 2nsiA-2bznA:
undetectable
2nsiB-2bznA:
undetectable		 2nsiA-2bznA:
22.17
2nsiB-2bznA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 6 PHE A 266
ALA A  53
LEU A 245
ALA A 246
 None
IMP  A1338 (-3.4A)
None
None
 0.93A 2vcvB-2bznA:
undetectable		 2vcvB-2bznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 6 PHE A 266
ALA A  53
LEU A 245
ALA A 246
 None
IMP  A1338 (-3.4A)
None
None
 0.93A 2vcvK-2bznA:
undetectable		 2vcvK-2bznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		3 / 3 PRO A 296
PHE A 266
LYS A 264
 None
 1.17A 3bjwG-2bznA:
undetectable		 3bjwG-2bznA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.47A 3e7gA-2bznA:
undetectable
3e7gB-2bznA:
0.0		 3e7gA-2bznA:
21.80
3e7gB-2bznA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 7 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.48A 3e7gC-2bznA:
0.1
3e7gD-2bznA:
0.1		 3e7gC-2bznA:
21.80
3e7gD-2bznA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 9 GLY A 172
ALA A 173
ASP A 174
ILE A 175
LEU A 168
 None
 0.93A 3ogpA-2bznA:
undetectable		 3ogpA-2bznA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 9 GLY A 172
ALA A 173
ASP A 174
ILE A 175
LEU A 168
 None
 0.98A 3ogpB-2bznA:
undetectable		 3ogpB-2bznA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 12 GLY A 172
ALA A 173
ASP A 174
ILE A 175
LEU A 168
 None
 0.96A 3ogqB-2bznA:
undetectable		 3ogqB-2bznA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 7 PHE A 138
GLU A 167
MET A 164
ILE A 176
 None
 1.44A 4cx7C-2bznA:
undetectable
4cx7D-2bznA:
undetectable		 4cx7C-2bznA:
22.17
4cx7D-2bznA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ASN A 158
CYH A 186
THR A 188
MET A 269
 IMP  A1338 ( 4.3A)
IMP  A1338 (-2.5A)
None
None
 0.50A 4fo4A-2bznA:
41.7		 4fo4A-2bznA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 8 ASN A 158
GLY A 181
CYH A 186
THR A 188
MET A 269
 IMP  A1338 ( 4.3A)
None
IMP  A1338 (-2.5A)
None
None
 0.48A 4fo4B-2bznA:
42.0		 4fo4B-2bznA:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		7 / 9 ASP A 129
ASN A 158
ILE A 180
GLY A 181
CYH A 186
THR A 188
ASP A 219
 None
IMP  A1338 ( 4.3A)
None
None
IMP  A1338 (-2.5A)
None
IMP  A1338 (-2.7A)
 0.34A 4fxsA-2bznA:
41.3		 4fxsA-2bznA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 9 THR A  74
LEU A  99
ALA A  64
GLN A  91
PHE A  88
 None
 1.27A 4ltwA-2bznA:
undetectable		 4ltwA-2bznA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 9 LEU A 199
GLY A 235
ALA A 236
ASP A 237
VAL A 178
 None
 1.09A 4njtD-2bznA:
undetectable		 4njtD-2bznA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 8 ILE A 217
ILE A  51
ASN A  54
ALA A  75
 None
 0.81A 4ou1A-2bznA:
6.9		 4ou1A-2bznA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 5 GLU A 204
GLU A 163
TYR A 134
TYR A 196
 None
 1.33A 4twdA-2bznA:
0.0
4twdE-2bznA:
undetectable		 4twdA-2bznA:
18.84
4twdE-2bznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 5 TYR A 196
GLU A 204
GLU A 163
TYR A 134
 None
 1.38A 4twdA-2bznA:
undetectable
4twdB-2bznA:
undetectable		 4twdA-2bznA:
18.84
4twdB-2bznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 6 TYR A 134
GLU A 163
GLU A 204
TYR A 196
 None
 1.49A 4twdG-2bznA:
undetectable
4twdH-2bznA:
undetectable		 4twdG-2bznA:
18.84
4twdH-2bznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 6 TYR A 196
GLU A 204
GLU A 163
TYR A 134
 None
 1.36A 4twdG-2bznA:
undetectable
4twdH-2bznA:
undetectable		 4twdG-2bznA:
18.84
4twdH-2bznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 5 TYR A 196
GLU A 204
GLU A 163
TYR A 134
 None
 1.33A 4twdH-2bznA:
undetectable
4twdI-2bznA:
undetectable		 4twdH-2bznA:
18.84
4twdI-2bznA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		4 / 5 ILE A 154
PHE A 141
SER A 103
ALA A 156
 None
 1.15A 5msdA-2bznA:
3.5		 5msdA-2bznA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		3 / 3 GLY A 235
ASP A 237
ILE A 217
 None
 0.62A 6dgxB-2bznA:
undetectable		 6dgxB-2bznA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2bzn GMP REDUCTASE 2
(Homo
sapiens) 		5 / 12 PHE A  36
ILE A 175
LEU A 128
PHE A  38
ALA A 101
 None
 1.16A 6r2eE-2bznA:
undetectable		 6r2eE-2bznA:
21.41