SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2bzw APOPTOSIS REGULATOR
BCL-X
(Mus
musculus) 		4 / 5 PHE A 144
PHE A 143
PHE A 123
VAL A   9
 None
 1.10A 2lh6A-2bzwA:
undetectable		 2lh6A-2bzwA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 2bzw APOPTOSIS REGULATOR
BCL-X
BCL2-ANTAGONIST OF
CELL DEATH
(Mus
musculus;
Mus
musculus) 		5 / 10 PHE A 146
GLN A 125
GLY B 106
LEU B 109
PHE A 123
 None
 1.36A 2ok6A-2bzwA:
undetectable
2ok6H-2bzwA:
undetectable		 2ok6A-2bzwA:
19.73
2ok6H-2bzwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2bzw APOPTOSIS REGULATOR
BCL-X
(Mus
musculus) 		4 / 7 GLY A 147
ASP A  11
LEU A  90
ARG A  91
 None
 0.77A 2uyqA-2bzwA:
undetectable		 2uyqA-2bzwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2bzw APOPTOSIS REGULATOR
BCL-X
(Mus
musculus) 		4 / 5 PHE A 144
TYR A 173
LEU A  17
LYS A  16
 None
 1.48A 3sugA-2bzwA:
undetectable		 3sugA-2bzwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bzw APOPTOSIS REGULATOR
BCL-X
BCL2-ANTAGONIST OF
CELL DEATH
(Mus
musculus) 		3 / 3 TYR B 105
GLU A 124
TYR A 173
 None
 0.81A 3ug8A-2bzwB:
undetectable		 3ug8A-2bzwB:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2bzw APOPTOSIS REGULATOR
BCL-X
(Mus
musculus) 		4 / 5 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.20A 4fglC-2bzwA:
undetectable		 4fglC-2bzwA:
21.31