SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		3 / 3 ILE A 195
ILE A 240
THR A 236
 None
 0.32A 1rg7A-2c07A:
1.9		 1rg7A-2c07A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		6 / 12 GLY A 116
ASP A 101
ASP A 105
GLY A  72
ALA A  84
ILE A 107
 None
None
None
SO4  A   2 (-3.3A)
None
None
 1.31A 2nmzA-2c07A:
undetectable		 2nmzA-2c07A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 ILE A  75
ILE A  79
ARG A 193
ALA A  66
 None
 0.67A 2nniA-2c07A:
undetectable		 2nniA-2c07A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 TYR A  58
SER A 285
CYH A  60
ILE A 143
 None
 1.27A 2xz5A-2c07A:
undetectable
2xz5B-2c07A:
undetectable		 2xz5A-2c07A:
19.52
2xz5B-2c07A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 ILE A 197
ASN A 171
SER A 215
SER A 199
 None
 1.09A 2zw9B-2c07A:
5.8		 2zw9B-2c07A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ILE A 197
VAL A  90
ILE A 107
ILE A  75
ALA A 148
 None
 1.20A 3ohtA-2c07A:
undetectable
3ohtB-2c07A:
undetectable		 3ohtA-2c07A:
24.44
3ohtB-2c07A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 9 ILE A  91
ILE A  93
VAL A 141
ILE A 178
ILE A 182
 None
 1.25A 3p4wB-2c07A:
undetectable		 3p4wB-2c07A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		3 / 3 HIS A  89
HIS A 138
ILE A  91
 None
 0.79A 3u52A-2c07A:
undetectable
3u52C-2c07A:
undetectable		 3u52A-2c07A:
20.08
3u52C-2c07A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 SER A 199
ILE A  75
TYR A 212
GLY A 243
 None
 1.05A 3uboB-2c07A:
6.5		 3uboB-2c07A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 GLY A 202
ASN A 206
ILE A 200
ALA A 241
VAL A 297
 None
 1.14A 4dx5B-2c07A:
undetectable		 4dx5B-2c07A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 LEU A 283
GLU A 229
GLY A 293
PHE A 222
ILE A 240
 None
 1.22A 4hytA-2c07A:
undetectable		 4hytA-2c07A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 GLY A 202
ASN A 206
ILE A 200
ALA A 241
VAL A 297
 None
 1.12A 4u8yB-2c07A:
undetectable		 4u8yB-2c07A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 GLY A 202
ASN A 206
ILE A 200
ALA A 241
VAL A 297
 None
 1.12A 4u95B-2c07A:
undetectable		 4u95B-2c07A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 GLY A  72
ARG A  77
GLY A  76
GLU A  78
 SO4  A   2 (-3.3A)
None
None
None
 1.20A 4z2eB-2c07A:
undetectable
4z2eC-2c07A:
2.7		 4z2eB-2c07A:
20.32
4z2eC-2c07A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 11 ILE A 197
THR A 223
VAL A 295
VAL A 297
LEU A 283
 None
 1.40A 5jkwA-2c07A:
undetectable		 5jkwA-2c07A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 PRO A 181
ILE A 182
ILE A  93
HIS A 138
VAL A 141
 None
 1.30A 6j21A-2c07A:
undetectable		 6j21A-2c07A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 LEU A  83
ILE A  79
LEU A 279
ILE A 240
ALA A 241
 None
 1.32A 6qxsD-2c07A:
undetectable		 6qxsD-2c07A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 LEU A  83
ILE A  79
LEU A 279
ILE A 240
ALA A 241
 None
 1.25A 6qyaB-2c07A:
undetectable		 6qyaB-2c07A:
20.24