SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		3 / 3 MET A 121
LEU A 124
SER A 125
 None
 0.69A 1ee2A-2c08A:
undetectable		 1ee2A-2c08A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		3 / 3 LEU A 233
VAL A 236
LEU A 240
 None
 0.53A 1mz9B-2c08A:
undetectable		 1mz9B-2c08A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		3 / 3 GLU A 162
LEU A 166
LEU A 187
 None
 0.44A 3ohtA-2c08A:
2.3		 3ohtA-2c08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		3 / 3 GLU A 162
LEU A 166
LEU A 187
 None
 0.46A 3ohtB-2c08A:
2.1		 3ohtB-2c08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		3 / 3 TYR A 170
LEU A 158
LYS A 159
 None
 0.71A 3sueD-2c08A:
undetectable		 3sueD-2c08A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		4 / 8 ARG A 239
GLU A 116
GLU A 119
ARG A 122
 None
 1.18A 4bqfB-2c08A:
undetectable		 4bqfB-2c08A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		3 / 3 PHE A 168
ASP A 167
LYS A 171
 None
 0.82A 6awtD-2c08A:
undetectable		 6awtD-2c08A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		4 / 6 SER A  44
ASP A 148
GLN A 155
THR A  52
 None
 1.37A 6djzA-2c08A:
undetectable		 6djzA-2c08A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Rattus
norvegicus) 		4 / 8 MET A 207
ILE A 209
THR A  43
VAL A  42
 None
 0.92A 6fbvC-2c08A:
undetectable		 6fbvC-2c08A:
10.85