SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_ACTB1503_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 4 TYR A1160
GLN A1168
HIS A1202
ARG A1199
 None
 1.46A 1zlqB-2c0gA:
0.0		 1zlqB-2c0gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		3 / 3 GLY A1148
GLU A1186
ASN A1237
 None
 0.53A 1zq9A-2c0gA:
undetectable		 1zq9A-2c0gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 8 ALA A1064
PHE A1065
ALA A1069
LEU A1076
 None
 0.86A 2bxmA-2c0gA:
2.6		 2bxmA-2c0gA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		3 / 3 PHE A1049
PHE A1109
PHE A1111
 None
 0.85A 2od9A-2c0gA:
undetectable		 2od9A-2c0gA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 5 LEU A1076
ALA A1072
ILE A1144
SER A1068
 None
 1.10A 2othA-2c0gA:
undetectable		 2othA-2c0gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		3 / 3 PHE A1049
PHE A1109
PHE A1111
 None
 0.85A 2qqgA-2c0gA:
undetectable		 2qqgA-2c0gA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 5 PHE A1049
PHE A1135
PHE A1111
ILE A1144
 None
 1.39A 2v0mD-2c0gA:
undetectable		 2v0mD-2c0gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		5 / 12 ALA A1079
LEU A1077
SER A1066
GLY A1113
ALA A1115
 None
 1.01A 3lbdA-2c0gA:
undetectable		 3lbdA-2c0gA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		3 / 3 PRO A1141
THR A1140
LEU A1076
 None
 0.77A 3ttrA-2c0gA:
undetectable		 3ttrA-2c0gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 8 ASP A1029
VAL A1039
PHE A1049
LEU A1094
 None
 0.85A 4f8hA-2c0gA:
3.3
4f8hB-2c0gA:
3.3		 4f8hA-2c0gA:
22.02
4f8hB-2c0gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 8 ASP A1029
VAL A1039
PHE A1049
LEU A1094
 None
 0.85A 4f8hB-2c0gA:
3.3
4f8hC-2c0gA:
3.3		 4f8hB-2c0gA:
22.02
4f8hC-2c0gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 8 ASP A1029
VAL A1039
PHE A1049
LEU A1094
 None
 0.86A 4f8hC-2c0gA:
3.3
4f8hD-2c0gA:
3.3		 4f8hC-2c0gA:
22.02
4f8hD-2c0gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 8 ASP A1029
VAL A1039
PHE A1049
LEU A1094
 None
 0.85A 4f8hD-2c0gA:
3.3
4f8hE-2c0gA:
3.3		 4f8hD-2c0gA:
22.02
4f8hE-2c0gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 8 VAL A1039
PHE A1049
LEU A1094
ASP A1029
 None
 0.87A 4f8hA-2c0gA:
3.3
4f8hE-2c0gA:
3.3		 4f8hA-2c0gA:
22.02
4f8hE-2c0gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		3 / 3 ASP A1029
VAL A1046
ASN A1091
 None
 0.70A 4lmnA-2c0gA:
undetectable		 4lmnA-2c0gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2c0g WINDBEUTEL PROTEIN
(Drosophila
melanogaster) 		4 / 5 HIS A1070
ILE A1078
PHE A1042
ALA A1079
 None
 1.07A 5msdA-2c0gA:
2.4		 5msdA-2c0gA:
11.88