SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 VAL A 235
VAL A 237
TRP A 172
 None
 0.77A 1bdwA-2c0hA:
undetectable
1bdwB-2c0hA:
undetectable		 1bdwA-2c0hA:
7.64
1bdwB-2c0hA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 ALA A  38
VAL A  78
TRP A  79
 None
 0.99A 1c4dA-2c0hA:
undetectable
1c4dB-2c0hA:
undetectable		 1c4dA-2c0hA:
7.64
1c4dB-2c0hA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 7 TYR A 151
VAL A 229
HIS A  81
LEU A 103
 None
 1.03A 1j96B-2c0hA:
8.9		 1j96B-2c0hA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 LYS A 292
ILE A 306
THR A 246
 None
 0.83A 1rx3A-2c0hA:
undetectable		 1rx3A-2c0hA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 7 GLY A 316
SER A 319
SER A 321
GLU A 320
 None
 0.95A 2c8aB-2c0hA:
undetectable		 2c8aB-2c0hA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 7 GLY A 316
SER A 319
SER A 321
GLU A 320
 None
 0.98A 2c8aD-2c0hA:
undetectable		 2c8aD-2c0hA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		6 / 12 ASN A 176
GLU A 177
HIS A 277
TYR A 279
GLU A 308
TRP A 337
 None
 0.80A 2v3dA-2c0hA:
15.7		 2v3dA-2c0hA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 7 MET A 107
ALA A 162
ALA A 160
LEU A 125
 None
 0.91A 2wx2A-2c0hA:
undetectable		 2wx2A-2c0hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 8 GLY A 128
ALA A 129
GLY A 204
ILE A 182
 None
 0.71A 3so9A-2c0hA:
undetectable		 3so9A-2c0hA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 TRP A  79
TRP A 337
THR A 340
 None
 1.21A 4bboB-2c0hA:
undetectable		 4bboB-2c0hA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 LYS A 292
ILE A 306
THR A 246
 None
 0.86A 4gh8A-2c0hA:
undetectable		 4gh8A-2c0hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 ASP A 100
TRP A 172
SER A  86
 None
 1.01A 4lrhA-2c0hA:
undetectable		 4lrhA-2c0hA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		5 / 8 ASP A 245
VAL A 219
TYR A 255
SER A 239
ALA A 223
 None
 1.38A 4m48A-2c0hA:
undetectable		 4m48A-2c0hA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 6 TYR A 279
GLY A 307
GLU A 308
ASP A 173
 None
 1.29A 5emlA-2c0hA:
7.0		 5emlA-2c0hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 8 ASN A 253
PHE A 295
HIS A 277
THR A 270
 None
 1.33A 5hqaA-2c0hA:
2.1		 5hqaA-2c0hA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		5 / 12 VAL A  96
GLU A  89
LEU A 156
ALA A 155
THR A 124
 None
 1.18A 5nd3B-2c0hA:
3.2		 5nd3B-2c0hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 TRP A 126
MET A 142
ASN A 139
 None
 1.22A 5uc1B-2c0hA:
undetectable		 5uc1B-2c0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		3 / 3 TRP A 126
MET A 142
ASN A 139
 None
 1.15A 5uc1A-2c0hA:
undetectable		 5uc1A-2c0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		5 / 12 GLY A 307
GLN A 275
VAL A 276
PHE A 122
LEU A  26
 None
 1.24A 5uc3B-2c0hA:
undetectable		 5uc3B-2c0hA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Mytilus
edulis) 		4 / 6 PHE A 218
ILE A 174
LEU A 260
GLY A 269
 None
 0.96A 5x5qE-2c0hA:
undetectable		 5x5qE-2c0hA:
20.51