SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		5 / 11 LEU A  67
ALA A  23
VAL A  70
MET A  27
LEU A 110
 None
None
None
None
HEM  A1152 ( 4.6A)
 1.47A 1qabE-2c0kA:
undetectable		 1qabE-2c0kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		4 / 7 PHE A 136
VAL A  70
VAL A  74
LEU A  77
 None
 0.91A 3hs6B-2c0kA:
undetectable		 3hs6B-2c0kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		4 / 8 GLU A  22
GLU A  26
LYS A  29
ARG A  30
 None
 0.65A 4bqfB-2c0kA:
undetectable		 4bqfB-2c0kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		3 / 3 VAL A   6
PHE A  86
ARG A 138
 None
 0.86A 4xr4B-2c0kA:
undetectable		 4xr4B-2c0kA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		4 / 6 LYS A   1
GLY A  82
SER A  78
LEU A  77
 None
 1.19A 5bphA-2c0kA:
undetectable		 5bphA-2c0kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		4 / 7 LYS A   1
GLY A  82
SER A  78
LEU A  77
 None
 1.03A 5bphB-2c0kA:
undetectable		 5bphB-2c0kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		4 / 6 LYS A   1
GLY A  82
SER A  78
LEU A  77
 None
 1.12A 5bphD-2c0kA:
undetectable		 5bphD-2c0kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c0k HEMOGLOBIN
(Gasterophilus
intestinalis) 		4 / 7 TYR A 140
ILE A 142
PHE A 135
GLY A  73
 None
 0.94A 5esmA-2c0kA:
undetectable		 5esmA-2c0kA:
14.69