SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A 632
VAL A 576
LEU A 607
ALA A 582
 None
 0.93A 1fiqC-2c0lA:
undetectable		 1fiqC-2c0lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 632
SER A 629
ASP A 627
PHE A 635
 None
 1.25A 1ismB-2c0lA:
undetectable		 1ismB-2c0lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 603
ARG A 608
ALA A 610
ARG A 626
GLU A 601
 None
 1.45A 1ki7B-2c0lA:
undetectable		 1ki7B-2c0lA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
(Homo
sapiens) 		4 / 7 GLN B 116
PHE B  55
MET B 104
ALA B 102
 None
 0.91A 1linA-2c0lB:
undetectable		 1linA-2c0lB:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 494
LEU A 497
LEU A 500
GLN A 419
LEU A 467
 None
 1.23A 1zucB-2c0lA:
undetectable		 1zucB-2c0lA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 GLY A 495
THR A 512
ALA A 513
ALA A 514
 None
 0.52A 2ej3A-2c0lA:
undetectable		 2ej3A-2c0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 GLY A 495
THR A 512
ALA A 513
ALA A 514
 None
 0.50A 2ej3C-2c0lA:
undetectable		 2ej3C-2c0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 10 SER A 558
TYR A 545
ALA A 548
ASN A 526
ALA A 544
 None
 1.45A 2r2vC-2c0lA:
undetectable
2r2vF-2c0lA:
undetectable
2r2vG-2c0lA:
undetectable		 2r2vC-2c0lA:
8.76
2r2vF-2c0lA:
8.76
2r2vG-2c0lA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
(Homo
sapiens) 		5 / 11 CYH B  91
LEU B 127
ALA B 128
LEU B 131
ASN B 133
 None
 1.25A 3e22D-2c0lB:
undetectable		 3e22D-2c0lB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 524
GLN A 403
LEU A 392
VAL A 411
 None
 0.82A 3g8iA-2c0lA:
undetectable		 3g8iA-2c0lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 637
PRO A 638
LEU A 632
 None
 0.53A 3hcrA-2c0lA:
undetectable		 3hcrA-2c0lA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 ASN A 415
THR A 414
LEU A 500
ASN A 561
 None
 1.13A 3kp2A-2c0lA:
undetectable
3kp2B-2c0lA:
undetectable		 3kp2A-2c0lA:
16.33
3kp2B-2c0lA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
NONSPECIFIC
LIPID-TRANSFER
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN B 140
ASN A 561
GLU A 383
 None
 0.91A 3kpdB-2c0lB:
undetectable		 3kpdB-2c0lB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 6 TYR A 555
GLN A 552
GLN A 586
GLU A 359
 None
 1.25A 4azvA-2c0lA:
undetectable		 4azvA-2c0lA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 351
LEU A 375
GLN A 347
GLU A 341
 None
 1.27A 4i41A-2c0lA:
undetectable		 4i41A-2c0lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A 557
GLU A 385
ASN A 602
 None
 0.78A 4imaD-2c0lA:
undetectable		 4imaD-2c0lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A 557
GLU A 385
ASN A 602
 None
 0.83A 4ip7D-2c0lA:
undetectable		 4ip7D-2c0lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ASN A 602
LEU A 609
ILE A 567
CYH A 566
LEU A 569
 None
 1.50A 4k36B-2c0lA:
0.0		 4k36B-2c0lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.95A 4k8cA-2c0lA:
undetectable		 4k8cA-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.96A 4kahA-2c0lA:
undetectable		 4kahA-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.95A 4kahB-2c0lA:
undetectable		 4kahB-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.95A 4kanA-2c0lA:
undetectable		 4kanA-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.94A 4kanB-2c0lA:
undetectable		 4kanB-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.97A 4kbeA-2c0lA:
undetectable		 4kbeA-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.93A 4kbeB-2c0lA:
undetectable		 4kbeB-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.96A 4lbgA-2c0lA:
undetectable		 4lbgA-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 565
TYR A 545
PRO B 138
 None
 0.95A 4lbgB-2c0lA:
undetectable		 4lbgB-2c0lA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
NONSPECIFIC
LIPID-TRANSFER
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 139
ILE A 567
GLY A 563
ARG A 608
PHE A 579
 None
 1.13A 4obwC-2c0lB:
undetectable		 4obwC-2c0lB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
NONSPECIFIC
LIPID-TRANSFER
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 139
ILE A 567
GLY A 563
ARG A 608
PHE A 579
 None
 1.11A 4obwD-2c0lB:
undetectable		 4obwD-2c0lB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 4 ARG A 345
GLY A 349
GLU A 348
 None
 0.60A 4z2dB-2c0lA:
undetectable
4z2dC-2c0lA:
undetectable		 4z2dB-2c0lA:
22.05
4z2dC-2c0lA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 5 GLU A 383
ALA A 380
GLU A 385
ASN A 415
 None
 0.95A 5dwkC-2c0lA:
undetectable		 5dwkC-2c0lA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 410
LEU A 409
ALA A 408
THR A 377
LEU A 523
 None
 1.21A 5k9dA-2c0lA:
undetectable		 5k9dA-2c0lA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 THR A 378
PRO A 592
ARG A 590
 None
 0.87A 5nd7B-2c0lA:
undetectable		 5nd7B-2c0lA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN
(Homo
sapiens) 		3 / 3 LEU B 131
ALA B 128
LEU B 103
 None
 0.45A 5uunB-2c0lB:
undetectable		 5uunB-2c0lB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 564
GLY A 529
ALA A 533
ALA A 544
ALA A 543
 None
 0.98A 5zw4A-2c0lA:
undetectable		 5zw4A-2c0lA:
22.47