SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 7 GLY A 149
ALA A 138
TYR A 153
GLU A  42
 None
 0.88A 1dmaA-2c0nA:
undetectable		 1dmaA-2c0nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		3 / 3 ASP A  63
ARG A  14
ARG A  41
 None
 0.99A 3k37A-2c0nA:
undetectable		 3k37A-2c0nA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 5 ILE A 123
PHE A 154
ASP A 151
GLU A 150
 None
 1.12A 3kp6A-2c0nA:
0.0
3kp6B-2c0nA:
undetectable		 3kp6A-2c0nA:
21.27
3kp6B-2c0nA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 10 ALA A  44
LEU A 118
ILE A 123
THR A 162
VAL A 152
 None
None
None
None
DIO  A1201 (-4.0A)
 1.30A 3r9cA-2c0nA:
undetectable		 3r9cA-2c0nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		3 / 3 ARG A 184
GLU A 105
TYR A  90
 None
 1.01A 4r29D-2c0nA:
undetectable		 4r29D-2c0nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 7 ALA A  44
ILE A 123
LEU A 118
PHE A  59
 None
 1.01A 4uymA-2c0nA:
undetectable		 4uymA-2c0nA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		3 / 3 LEU A 188
PHE A 173
ILE A 187
 None
 0.72A 5dzk1-2c0nA:
undetectable
5dzkF-2c0nA:
undetectable
5dzkM-2c0nA:
undetectable		 5dzk1-2c0nA:
2.20
5dzkF-2c0nA:
23.11
5dzkM-2c0nA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 8 GLU A 150
PRO A   8
GLY A 119
ASP A  61
 None
 1.01A 5kgpA-2c0nA:
undetectable		 5kgpA-2c0nA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 8 GLU A 150
PRO A   8
GLY A 119
ASP A  61
 None
 1.02A 5kgpB-2c0nA:
undetectable		 5kgpB-2c0nA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 12 SER A  98
ILE A  26
PHE A  20
PHE A  71
LEU A 165
 None
 1.29A 6a93A-2c0nA:
undetectable		 6a93A-2c0nA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 9 VAL A 113
LEU A 118
GLY A  87
THR A 162
VAL A  84
 None
 1.19A 6czmA-2c0nA:
undetectable
6czmB-2c0nA:
undetectable		 6czmA-2c0nA:
22.73
6czmB-2c0nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 9 VAL A 113
LEU A 118
GLY A  87
THR A 162
VAL A  84
 None
 1.20A 6czmB-2c0nA:
undetectable
6czmC-2c0nA:
undetectable		 6czmB-2c0nA:
22.73
6czmC-2c0nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 9 VAL A 113
LEU A 118
GLY A  87
THR A 162
VAL A  84
 None
 1.19A 6czmD-2c0nA:
undetectable
6czmE-2c0nA:
undetectable		 6czmD-2c0nA:
22.73
6czmE-2c0nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2c0n A197
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 6 GLY A 119
THR A 121
ILE A 123
PHE A 127
 None
 0.76A 6f8cA-2c0nA:
undetectable		 6f8cA-2c0nA:
18.89