SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		3 / 3 ALA A 132
VAL A 268
TRP A 106
 None
 0.99A 1c4dA-2c0yA:
undetectable
1c4dB-2c0yA:
undetectable		 1c4dA-2c0yA:
7.01
1c4dB-2c0yA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		3 / 3 TRP A 106
ALA A 132
VAL A 268
 None
 0.93A 1c4dA-2c0yA:
undetectable
1c4dB-2c0yA:
undetectable		 1c4dA-2c0yA:
7.01
1c4dB-2c0yA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 5 PHE A 289
TYR A 247
VAL A 281
VAL A 115
 None
 1.47A 1dz6B-2c0yA:
undetectable		 1dz6B-2c0yA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		5 / 12 LEU A  65
ASN A 283
LEU A  76
ALA A 124
ALA A 123
 None
 1.10A 1n5xA-2c0yA:
undetectable		 1n5xA-2c0yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		5 / 12 LEU A  65
ASN A 283
LEU A  76
ALA A 124
ALA A 123
 None
 1.09A 1n5xB-2c0yA:
undetectable		 1n5xB-2c0yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 8 ASP A 221
TYR A  92
LEU A 215
GLY A 218
 None
 0.94A 1rmtC-2c0yA:
undetectable		 1rmtC-2c0yA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		6 / 10 GLN A 118
GLY A 122
TRP A 125
PHE A 127
SER A 128
HIS A 263
 None
 0.25A 1stfE-2c0yA:
29.8
1stfI-2c0yA:
undetectable		 1stfE-2c0yA:
33.92
1stfI-2c0yA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 7 GLY A  61
HIS A  47
ASP A  59
TYR A  58
 None
 1.16A 1th6A-2c0yA:
undetectable		 1th6A-2c0yA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 7 GLY A  61
HIS A  47
ASP A  59
TYR A  58
 None
 1.16A 2armA-2c0yA:
undetectable		 2armA-2c0yA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		5 / 10 PHE A 127
ASN A 162
GLY A 167
ALA A 123
GLN A 118
 None
 1.39A 2x2iB-2c0yA:
undetectable		 2x2iB-2c0yA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 7 GLN A 118
GLY A 122
HIS A 263
TRP A 285
 None
 0.48A 3ai8A-2c0yA:
25.2		 3ai8A-2c0yA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		3 / 3 SER A 156
GLY A 161
GLY A 168
 None
 0.55A 3bogA-2c0yA:
undetectable
3bogC-2c0yA:
undetectable		 3bogA-2c0yA:
undetectable
3bogC-2c0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 7 TYR A 191
ASN A 283
HIS A 263
ALA A 124
 None
 1.05A 3frqB-2c0yA:
undetectable		 3frqB-2c0yA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 8 SER A 243
PHE A 244
TYR A 252
VAL A 261
 None
 1.10A 3jq7C-2c0yA:
undetectable		 3jq7C-2c0yA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 5 TYR A 191
SER A 284
ASP A 186
ILE A 183
 None
 1.38A 3uj7B-2c0yA:
undetectable		 3uj7B-2c0yA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 8 TRP A 285
LEU A  76
GLU A  72
HIS A  64
 None
 1.43A 3zmdA-2c0yA:
0.0
3zmdB-2c0yA:
0.0		 3zmdA-2c0yA:
19.18
3zmdB-2c0yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		4 / 6 TYR A 191
ASP A 154
GLN A 196
GLU A 158
 None
 1.25A 4azvA-2c0yA:
undetectable		 4azvA-2c0yA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		5 / 12 PHE A 174
LEU A 133
ALA A 132
LEU A 266
GLY A 236
 None
 1.10A 4dm8B-2c0yA:
undetectable		 4dm8B-2c0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		5 / 9 LEU A 223
GLY A 269
VAL A 233
SER A 234
VAL A 235
 None
 1.15A 4qd3A-2c0yA:
undetectable		 4qd3A-2c0yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2c0y PROCATHEPSIN S
(Homo
sapiens) 		3 / 3 HIS A  64
ASN A  63
LEU A 246
 None
 0.88A 6f7lB-2c0yA:
undetectable		 6f7lB-2c0yA:
18.94